Production of Bifidibacterial Cells by Using a Novel Membrane Co-Culture System with Supplying of a New Bifidogenic Growth Stimulator.

通过使用新型膜共培养系统并提供新型双歧生长刺激剂来生产双歧杆菌细胞。

基本信息

  • 批准号:
    09650870
  • 负责人:
  • 金额:
    $ 2.05万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1997
  • 资助国家:
    日本
  • 起止时间:
    1997 至 1998
  • 项目状态:
    已结题

项目摘要

1. Several species of Propionibacterium produced bifidogenic growth stimulator (BGS), that is, 2-amino-3-carboxy- l, 4-naphthoquinone in culture broth. A bioassay system for BGS activity using Bifidobacterium longum as a test microorganism was established.2. Propionibacterium freudenreichii preferred lactic acid to sugars such as lactose and glucose as a carbon source. Therefore, P.freudenreichii grew well in a co-culture of P.freudenreichii and B.adolescentis, where lactic acid was produced from glucose by B.adolescentis.3. A novel bioreactor system with two fermentors and two microfiltration modules was developed for efficient production bifidobacterial cells by co-culture of P.freudenreichii and B.adolescentis as well as clarification of interactions between the two bacteria.4. The proposed co-culture system allowed the successful exchange of culture medium between two fermentors. When P.freudenreichii and B.adolescentis were cultivated individually in the new co-culture system, the amount of bifidobacterial cells produced was twice as high as that with batch culture.
1. 几种丙酸杆菌在培养液中产生双歧生长刺激剂(BGS),即2-氨基-3-羧基- 1,4 -萘醌。以长双歧杆菌为检测微生物,建立了BGS活性的生物测定系统。弗氏丙酸杆菌更喜欢乳酸而不是糖,如乳糖和葡萄糖作为碳源。因此,P.freudenreichii在P.freudenreichii和b .青春期的共同培养中生长良好,其中b .青春期的葡萄糖产生乳酸。采用两个发酵罐和两个微滤模组的新型生物反应器系统,对弗氏双歧杆菌和青春期双歧杆菌进行了高效共培养,并对两种细菌之间的相互作用进行了澄清。所提出的共培养系统允许两个发酵罐之间成功地交换培养基。当在新的共培养体系中单独培养弗氏双歧杆菌和少年双歧杆菌时,双歧杆菌细胞的产量是批量培养的两倍。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Masayuki Taniguchi: "Production of Bifidogenic Growth Stimulator by Propionibacterium freudenreichii. (Japanese)" Seibutu-Kogaku Kaishi. Vol.75, No.5. 366-367 (1997)
Masayuki Taniguchi:“费氏丙酸杆菌生产双歧生长刺激剂。(日语)”Seibutu-Kogaku Kaishi。
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    0
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谷口正之: "プロピオン酸菌によるビフィズス菌増殖因子の生産" 生物工学会誌. 75巻5号. 366-367 (1997)
Masayuki Taniguchi:“丙酸细菌的双歧杆菌生长因子的生产”日本生物技术学会杂志,第 75 卷,第 5 期。366-367(1997)。
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谷口正之: "プロピオン酸菌によるビフィズス菌増殖因子の生産" 生物工学会誌. 75巻・5号. 366-367 (1997)
Masayuki Taniguchi:“丙酸细菌的双歧杆菌生长因子的生产”日本生物技术学会杂志,第 75 卷,第 5 期。366-367(1997)。
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TANIGUCHI Masayuki其他文献

TANIGUCHI Masayuki的其他文献

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{{ truncateString('TANIGUCHI Masayuki', 18)}}的其他基金

Elucidation of action mechanisms against human pathogenic microorganisms of protein components from rice grain and their application to food and drug
米粒蛋白成分对人类病原微生物作用机制的阐明及其在食品和药物中的应用
  • 批准号:
    23560939
  • 财政年份:
    2011
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Proteomic analysis of antimicrobial proteins from rice grain and clarification of their action mechanisms against periodontal pathogenic bacteria
米粒抗菌蛋白的蛋白质组学分析及其对抗牙周病原菌的作用机制
  • 批准号:
    20560725
  • 财政年份:
    2008
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Genetic and proteomic analysis of novel antimicrobial proteins from rice and their application to harmful microorganisms
水稻新型抗菌蛋白的遗传和蛋白质组学分析及其在有害微生物中的应用
  • 批准号:
    18560749
  • 财政年份:
    2006
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Rote of carciac 5'AMPK
癌基因 5AMPK
  • 批准号:
    13670747
  • 财政年份:
    2001
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Conversion of Agricultural Wastes to Lactic Acid by a Combination of Pentose-fermentative Lactic Acid Bacteria and Reversibly Soluble-insoluble Enzymes
通过戊糖发酵乳酸菌和可逆可溶-不溶酶的组合将农业废物转化为乳酸
  • 批准号:
    13836003
  • 财政年份:
    2001
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Production of Bifidogenic Growth Stimulator and Its Application to Development of Probiotics
双歧生长刺激剂的制备及其在益生菌开发中的应用
  • 批准号:
    10555286
  • 财政年份:
    1998
  • 资助金额:
    $ 2.05万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B).

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前列腺细胞内痤疮丙酸杆菌感染是前列腺癌的独立危险因素
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