Architecture and Applications of Novel Fluorinated Molecular Assemblies Imparted by the Aggregations of Fluoroalkyl Segments

结果表明，以氟烷酰过氧化物为关键中间体，可以制备一系列含有羧基、酰胺基、甜菜碱和羟基等多种功能段的氟烷基化端盖低聚物。这些由此获得的氟烷基化端盖低聚物可溶于水和有机溶剂，并且能够有效地降低水的表面张力，具有类似CMC的明显断点，这与通常的低分子量氟化表面活性剂所达到的水平几乎相同。这是我们的氟烷基化端盖低聚表面活性剂的一个独特而有趣的特征。此外，氟烷基化端盖低聚物在水溶液中形成了由氟烷基化端基强聚集所赋予的分子组装，氟烷基化端盖丙烯酸和磺酸低聚物也被证明是体外人类免疫缺陷病毒1型（EV-1）的有效和选择性抑制剂。更有趣的是，含有甜菜碱或羟基段的氟烷基化端盖低聚物可能导致凝胶化，其中端盖氟烷基段的强聚集和离子或氢键相互作用的协同作用参与了在水和极性有机溶剂中建立get网络。

It was demonstrated that a series of fluoroalkylated end-capped oligomers containing various functional segments such as carboxy, amide, betaine, and hydroxy groups can be prepared by the use of fluoroalkanoyl peroxides as key intermediates. These thus-obtained fluoroalkylated end-capped oligomers were soluble in water and organic solvents, and were capable of reducing the surface tension of water effectively with a clear break point resembling a CMC, which is almost the same level as that achieved by the usual low molecular weight fluorinated surfactants. This is a unique and interesting feature of our fluoroalkylated end-capped oligo-surfactants. Furthermore, fluoroalkylated end-capped oligomers were suggested to form the molecular assemblies imparted by strong aggregation of the fluoroalkylated end-groups in aqueous solutions, and fluoroalkylated end-capped acrylic acid and sulfonic acid oligomers were also shown to be potent and selective inhibitors of human immunodeficiency virus type 1 (EV-1) in vitro. More interestingly, fluoroalkylated end-capped oligomers containing betaine or hydroxy segments could cause gelation, where the synergistic interactions of both the strong aggregation of the end-capped fluoroalkyl segments and the ionic or hydrogen-bonding interaction are involved in establishing a get network in water and polar organic solvents.