Architecture and Applications of Novel Fluorinated Molecular Assemblies Imparted by the Aggregations of Fluoroalkyl Segments

结果表明，一系列的氟烷基化封端的低聚物含有各种功能段，如羧基，酰胺，甜菜碱，和羟基基团，可以通过使用氟代烷酰基过氧化物作为关键中间体。这些由此获得的氟烷基化封端的低聚物可溶于水和有机溶剂，并且能够有效地降低水的表面张力，具有类似于CMC的清晰的断裂点，其几乎与通过通常的低分子量氟化表面活性剂实现的水平相同。这是我们的氟烷基化封端低聚表面活性剂的一个独特且有趣的特征。此外，氟烷基化封端的低聚物被建议形成由氟烷基化端基在水溶液中的强聚集所赋予的分子组装体，并且氟烷基化封端的丙烯酸和磺酸低聚物也被证明是体外人类免疫缺陷病毒1型（EV-1）的有效和选择性抑制剂。更有趣的是，含甜菜碱或羟基链段的氟烷基化封端低聚物可引起凝胶化，其中封端氟烷基链段的强聚集和离子或氢键相互作用的协同相互作用参与在水和极性有机溶剂中建立凝胶网络。

It was demonstrated that a series of fluoroalkylated end-capped oligomers containing various functional segments such as carboxy, amide, betaine, and hydroxy groups can be prepared by the use of fluoroalkanoyl peroxides as key intermediates. These thus-obtained fluoroalkylated end-capped oligomers were soluble in water and organic solvents, and were capable of reducing the surface tension of water effectively with a clear break point resembling a CMC, which is almost the same level as that achieved by the usual low molecular weight fluorinated surfactants. This is a unique and interesting feature of our fluoroalkylated end-capped oligo-surfactants. Furthermore, fluoroalkylated end-capped oligomers were suggested to form the molecular assemblies imparted by strong aggregation of the fluoroalkylated end-groups in aqueous solutions, and fluoroalkylated end-capped acrylic acid and sulfonic acid oligomers were also shown to be potent and selective inhibitors of human immunodeficiency virus type 1 (EV-1) in vitro. More interestingly, fluoroalkylated end-capped oligomers containing betaine or hydroxy segments could cause gelation, where the synergistic interactions of both the strong aggregation of the end-capped fluoroalkyl segments and the ionic or hydrogen-bonding interaction are involved in establishing a get network in water and polar organic solvents.