Development of Environmentally Responsive Antibacterial Materials Imparted by Fluorine

氟赋予环境响应型抗菌材料的研制

• 批准号: 12555255
• 负责人: SAWADA Hideo
• 金额: $ 7.49万
• 依托单位: NARA NATIONAL COLLEGE OF TECHNOLOGY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12555255/
• 关键词: fluorine; biocide; oil-repllency; environmentally response; polymeric material; surface modification; plastics; cellulose

New fluoroalkyl end-capped oligomers containing cationic segments such as ammonium andDimethyl (octyl)ammonium units were prepared by the use of fluoroalkanoyl peroxide as a key intermediate. These fluorinated oligomers containing cationic segments are easily soluble not only in water but also in common organic solvents, and were able to reduce the surface tension of water quite effectively with a clear breakpoint resembling a critical micelle concentration, the same as for low-molecular weight fluorinated surfactants. More interestingly, the modified poly (methyl methacrylate) or cellulose surface treated with these fluorinated cationic oligomers was shown to have a strong hydrophilicity with a high antibacterial activity. Therefore, these fluoroalkyl end-capped oligomers are applicable to new functional materials possessing not only the surface antibacterial activity but also the surface active property imparted by fluorine.

以过氧氟烷酰为关键中间体，合成了含铵、二甲基辛基铵等阳离子链段的新型含氟烷基封端低聚物。这些含有阳离子链段的含氟低聚物不仅易溶于水，而且易溶于普通有机溶剂，并能相当有效地降低水的表面张力，其断裂点接近临界胶束浓度，与低分子量含氟表面活性剂相同。更有趣的是，用这些含氟阳离子低聚物处理的改性聚甲基丙烯酸甲酯或纤维素表面具有很强的亲水性和较高的抗菌活性。因此，这些含氟烷基端基低聚物既具有表面抗菌活性，又具有氟赋予的表面活性，适用于新型功能材料。

项目成果

H. Sawada: "Fluorinated and Fluoro-silicone Surfactants"The Handbook of Oil Chemistry, 4^<th> ed. - Lipids and Surfactants. 526-528 (2001)

H. Sawada：“氟化和氟硅酮表面活性剂”石油化学手册，第 4 版。

沢田英夫: "フッ素系生理活性物質の進歩と応用展開:含フッ素オリゴマー類の合成と性質"シーエムシー. 85-99 (2000)

Hideo Sawada：“氟基生理活性物质的进展和应用开发：含氟低聚物的合成和性能”CMC 85-99（2000）。

H. Sawada: "Synthesis of Fluoroalkyl End-capped Co-oligomers Containing 8-Hydroxyquinolyl Segments and Application to Oligomer-Catalyzed Solvolysis Reactions"J. Fluorine Chem.. 107. 59-62 (2001)

H. Sawada：“含 8-羟基喹啉基链段的氟烷基封端共聚低聚物的合成及其在低聚物催化的溶剂分解反应中的应用”J。

沢田英夫: "過酸化フルオロアルカノイルの反応性を利用したフルオロアルキル基含有オリゴマー類の合成と分子集合体形成"高分子論文集. (印刷中). (2001)

Hideo Sawada：“利用氟代烷酰基过氧化物的反应性合成含氟烷基低聚物和形成分子聚集体”《聚合物科学与技术集》（2001 年出版）。

沢田英夫: "フルオロアルキル基の凝集効果が活かされた新しいフッ素系高分子界面活性剤"日本油化学会誌. 49. 1021-1033 (2000)

Hideo Sawada：“利用氟烷基团聚集效应的新型含氟聚合物表面活性剂”日本石油化学会杂志 49. 1021-1033 (2000)。