Development of Novel Biodegradable Polymers with High Melting Temperature

新型高熔点可生物降解聚合物的开发

• 批准号: 09650980
• 负责人: SHIRAHAMA Hiroyuki
• 金额: $ 1.98万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09650980/
• 关键词: high melting temperature; biodegradable polymer; lactide; lactone; depsipeptide; terpolymer; thermal property; mechanical property; ラクトン類

In this year, we have examined some properties and biodegradation of the polymers synthesized last year. Then, we have fed back the obtained results to polymer synthesis, and developed the polymers with good properties and biodegradability.We have prepared the following copolymers with melting temperature higher than 100ﾟC ; (R)-beta-butyrolactone [(R)-beta-BLupsilonepsilon-caprolactone (CL) copolymers ((R)-beta-BL/CL>75/25 ), _L-lactide (_LLA)/CL copolymers(_L-LA/CL>85/15) , and the copolymers of _L-LA with _L-DMO (_L-3, _<DL>6-dimethyl-2,5-morpholinedione ; one of cyclic depsipeptides) (_L-LA/_L-DMO>85/15) etc. The _L-LA/_L-DMO copolymers were degraded most by enzymes such as proteases.Subsequently, we have measured the thermal and mechanical properties of the _L-LA/_L-DMO (=92/8) copolymer. As a result, the thermal and tensile properties of this copolymer were kept at much the same levels as those of poly(_L-LA), however, the brittleness (the lack of flexibility) of poly(_L-LA) could not be improved Thus, we have prepared the _L-LA/_L-DMO/CL terpolymers ; the introduction of CL unit can be expected for improving the brittleness of poly(_L-LA) ; and examined some properties and biodegradability of the terpolymers. It has become apparent that the terpolymers containing ca 10mol% of CL unit, e.g., _L-LA/_L-DMO/CL (=88/4/8) copolymer shows a relatively high elongation, keeping good tensile strength and biodegradation. Henceforth, we will prepare these types of terpolymers, using various depsipeptides and lactones, and develop novel biodegradable polymers having both good properties and biodegradability.

在这一年里，我们已经检查了去年合成的聚合物的一些性能和生物降解性。然后，我们将所得结果反馈到聚合物合成中，开发出了性能良好且可生物降解的聚合物，制备了以下熔融温度高于100 ℃的共聚物：（R）-β-丁内酯[（R）-β-BL]-己内酯（CL）共聚物（（R）-β-BL/CL&gt;75/25），_L-丙交酯（_LLA）/CL共聚物（L-LA/CL&gt;85/15），以及L-LA与L-DMO（L-3，<DL>6-二甲基-2，5-吗啉二酮;环缩酚肽之一）（_L-LA/_L-DMO&gt;85/15）等。_L-LA/_L-DMO共聚物被酶如蛋白酶降解得最多。随后，我们测定了_L-LA/_L-DMO（=92/8）共聚物的热性能和力学性能。结果表明，该共聚物的热性能和拉伸性能与聚（L-LA）基本相同，但脆性有所降低因此，我们制备了L-LA/L-DMO/CL三元共聚物，CL单元的引入有望改善聚L-LA的脆性;并研究了三元共聚物的一些性能和生物降解性。很明显，含有约10mol% CL单元的三元共聚物，例如，L-LA/L-DMO/CL（=88/4/8）共聚物具有较高的伸长率，保持了较好的拉伸强度和生物降解性。然而，我们将使用各种缩肽和内酯制备这些类型的三元共聚物，并开发具有良好性能和生物降解性的新型生物降解聚合物。

项目成果

白浜 博幸: "デプシペプチド共重合体の合成と生分解性-アミノ酸ユニットの影響-" 高分子論文集. 55・6. 359-366 (1998)

Hiroyuki Shirahama：“缩酚肽共聚物的合成和生物降解性 - 氨基酸单元的影响 -” 高分子科学与技术杂志 55・6（1998）。

白浜博幸: "環状デプシペプチド/ε-カプロラクトン共重合体の合成と生分解性-ヒドロキシ酸ユニットの影響-"高分子論文集. 56・2. 77-85 (1999)

Hiroyuki Shirahama：“环状缩酚肽/ε-己内酯共聚物的合成和生物降解性-羟基酸单元的影响-”Kobunshi Ronsen 56・2（1999）。

H.Shirahama: "Synthesis and Biodegradation of Random and Block Copolymers of Lactide with epsilon-Caprolactone" Yukagaku(J.Jpn.Oil Chem.Soc.). 47(No.1). 73-81 (1998)

H.Shirahama：“丙交酯与ε-己内酯的无规和嵌段共聚物的合成和生物降解”Yukagaku（J.Jpn.Oil Chem.Soc.）。

H.Shirahama: "Synthesis and Biodegradability of Depsipeptide Copolymers-Effect of Amino Acid Unit-" Kobunshi Ronbunshu(Jpn.J.Polym.Sci.Technol.). 55(No.6). 359-366 (1998)

H.Shirahama：“缩酚肽共聚物的合成和生物降解性-氨基酸单元的影响-”Kobunshi Ronbunshu（Jpn.J.Polym.Sci.Technol.）。

白浜 博幸: "エコおよびバイオマテリアルとしての生分解性高分子" 高分子加工. 47・4. 175-182 (1998)

Hiroyuki Shirahama：“可生物降解的聚合物作为环保和生物材料”聚合物加工47·4（1998）。