Molecular control of cell migration during Xenopus gastrulation by different Wnt signaling pathways

不同Wnt信号通路对非洲爪蟾原肠胚形成过程中细胞迁移的分子控制

• 批准号: 88429801
• 负责人: Professorin Dr. Doris Wedlich
• 金额: --
• 依托单位: Abteilung für Zell- und Entwicklungsbiologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/88429801?language=en
• 关键词: Molecular; control; cell; migration; during

Convergent extension (CE) movements of the dorsal mesoderm make a major contribution to shaping the dorsal body axis of vertebrate embryos. In our previous research we have identified the protocadherin XPAPC as a key molecule that is regulated by the Wnt-5A/Ror2 signaling cascade and interacts with the Wnt/PCP pathway to coordinate CE movements in Xenopus laevis. Our future research will focus on (1) further characterization of the novel Wnt-5A/Ror2 pathway, including identification of additional effector proteins, (2) the functional and molecular interconnection of both non-canonical Wnt-signaling pathways and (3) on their evolutionary conservation. The latter is a novel aspect that arises by the integration into the research unit. By interspecies functional studies the conservation of the physiological role of Wnt-5a/Ror2 and Wnt/PCP pathways will be addressed in processes of Hydra regeneration and mouse myocardial remodeling.

脊椎动物胚胎背侧中胚层的会聚伸展（CE）运动对背侧体轴的形成有重要贡献。在我们以前的研究中，我们已经确定了原钙粘蛋白XPAPC作为一个关键分子，它是由Wnt-5A/Ror 2信号级联调节，并与Wnt/PCP途径相互作用，以协调非洲爪蟾CE运动。我们未来的研究将集中在（1）新的Wnt-5A/Ror 2通路的进一步表征，包括鉴定其他效应蛋白，（2）两种非经典Wnt信号通路的功能和分子互连，以及（3）它们的进化保守性。后者是一个新的方面，出现了融入研究单位。通过种间功能研究，Wnt-5a/Ror 2和Wnt/PCP通路的生理作用的保护将在水螅再生和小鼠心肌重塑过程中得到解决。