The elucidation of the mechanism in cancer microenvironment by ovarian cancer secretion exosome and the development of a next-generation cancer therapy by the exosome.

阐明卵巢癌分泌的外泌体在癌症微环境中的作用机制，并开发外泌体的下一代癌症疗法。

• 批准号: 26462541
• 负责人: SASAKI HIROSHI
• 金额: $ 3.16万
• 依托单位: Osaka Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462541/
• 关键词: エキソソーム; 卵巣癌; 癌微小環境; microRNA

项目成果

Gemcitabine as a molecular targeting agent that blocks the Akt cascade in platinum-resistant ovarian cancer.

• DOI: 10.1186/1757-2215-7-38
• 发表时间: 2014-04-09
• 期刊: Journal of ovarian research
• 影响因子: 4
• 作者: Kawaguchi H;Terai Y;Tanabe A;Sasaki H;Takai M;Fujiwara S;Ashihara K;Tanaka Y;Tanaka T;Tsunetoh S;Kanemura M;Ohmichi M
• 通讯作者: Ohmichi M

The efficacy of the cyclin-dependent kinase 4/6 inhibitor in endometrial cancer.

• DOI: 10.1371/journal.pone.0177019
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Tanaka T;Terai Y;Ashihara K;Fujiwara S;Tanaka Y;Sasaki H;Tsunetoh S;Ohmichi M
• 通讯作者: Ohmichi M

CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways.

• DOI: 10.3892/or.2017.5583
• 发表时间: 2017-06
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: Nakamura K;Terai Y;Tanabe A;Ono YJ;Hayashi M;Maeda K;Fujiwara S;Ashihara K;Nakamura M;Tanaka Y;Tanaka T;Tsunetoh S;Sasaki H;Ohmichi M
• 通讯作者: Ohmichi M