Development of Artificial Bone Marrow Chamber and the Establishment of New Concept of the Immune System

本研究通过作者研制的人工骨髓腔，解读了脊椎动物进化的原因、免疫系统的发育和骨髓造血的发育这三个谜题。通过人工骨髓腔的实验进化研究，我们发现骨髓造血的发生与地球化过程中重力作用的增加相对应，这与Lamarck的使用和废弃理论相吻合。我们尝试登陆爪蟾、墨西哥蝾螈和鲨鱼，即三爪螈和日本异齿兽。通过本实验，用分子生物学的方法从生物力学的角度对化生的使用和废弃理论进行了验证。几种典型脊椎动物的器官成功移植到哺乳动物的各自器官中。我们可以证实原型细胞是哺乳动物的胚胎干细胞。通过这个实验，可以验证海克尔的生物遗传学定律。之后，作者在哺乳动物的八种表型中验证了再现理论。经过这些实验，作者可以提出真正的使用和废弃理论，真正的生物遗传规律，以及免疫系统的新概念。

In this research, the three riddles of the vertebrates are read, i.e., the cause of the evolution, development of the immune system, and the development of bone marrow hemopoiesis, by means of artificial bone marrow chambers, which are developed by the authors. Through the experimental evolutionary studies using artificial bone marrow chambers, we find out that bone marrow hemopoiesis occur by correspondence to the increased gravity action during terrestrialization, which is coincide to the use and disuse theory of Lamarck. We try to land xenopus, Mexican salamanders, and sharks, i.e., Triakis and Heterodontus japonicus. Through this experiment verification of use and disuse theory is carried out as metaplasia through biomechanics by methods of molecular biology. Several organs of archetype vertebrates are transplanted into respective organs of the mammals successfully. We can verify the archetype cell to be embryogenic stem cell of the mammals. By this experiments the biogenetic law of Haeckel can be verified. After that the authors verify recapitulation theory in eight phenotypes in the mammals.After these experiments the authors can propose the genuine use and disuse theory, the genuine biogenetic law, as well as new concepts of the immune system.