Development of Artificial Bone Marrow Chamber and the Establishment of New Concept of the Immune System

本研究利用作者研制的人工骨髓室，解开了脊椎动物的三个谜题，即进化的原因、免疫系统的发育和骨髓造血的发育。通过人工骨髓室的实验进化研究，我们发现骨髓造血是通过陆化过程中重力作用的增加而发生的，这与拉马克的使用和废弃理论是一致的。我们试图让非洲爪哇、墨西哥火蜥蜴和鲨鱼，即Triakis和Heterodontus Japan onicus上岸。通过本实验，从生物力学的角度，运用分子生物学的方法，对使用与废弃理论进行化生验证。原型脊椎动物的几个器官被成功地移植到哺乳动物的各个器官中。我们可以证实该原型细胞是哺乳动物的胚胎干细胞。通过这个实验，可以验证海克尔的生物发生规律。之后，作者在哺乳动物的8个表型中验证了重述理论。在这些实验之后，作者可以提出真正的使用和废弃理论，真正的生物遗传规律，以及免疫系统的新概念。

In this research, the three riddles of the vertebrates are read, i.e., the cause of the evolution, development of the immune system, and the development of bone marrow hemopoiesis, by means of artificial bone marrow chambers, which are developed by the authors. Through the experimental evolutionary studies using artificial bone marrow chambers, we find out that bone marrow hemopoiesis occur by correspondence to the increased gravity action during terrestrialization, which is coincide to the use and disuse theory of Lamarck. We try to land xenopus, Mexican salamanders, and sharks, i.e., Triakis and Heterodontus japonicus. Through this experiment verification of use and disuse theory is carried out as metaplasia through biomechanics by methods of molecular biology. Several organs of archetype vertebrates are transplanted into respective organs of the mammals successfully. We can verify the archetype cell to be embryogenic stem cell of the mammals. By this experiments the biogenetic law of Haeckel can be verified. After that the authors verify recapitulation theory in eight phenotypes in the mammals.After these experiments the authors can propose the genuine use and disuse theory, the genuine biogenetic law, as well as new concepts of the immune system.