Emerging Topics in Immune System Plasticity: Cellular Networks, Metabolic Control

描述(由申请人提供)：请求支持由Steven L.Reiner、Erika L.Pearce和Yasmine Belkaid组织的题为免疫系统可塑性中的新主题：细胞网络、代谢控制和再生的Keystone研讨会。会议将于2013年1月15-20日在新墨西哥州圣达菲举行。免疫系统是一个多细胞网络，能够适应外部威胁。免疫细胞与其他防御措施(如屏障)合作，通过选择正确的反应来防止入侵并拒绝入侵者，同时对宿主造成最小的损害。免疫系统的一个关键特征是它的流动性和穿越时间和空间边界的能力。此外，免疫系统动力学包括细胞扩张、临时细胞定位、转录改变以及平衡分化和再生。这次会议将使不同的研究人员聚集在一起，更好地了解免疫反应是如何协调的，以应对细胞分化、功能、 和动态平衡。会议的目的是1)揭示在免疫反应的不同阶段发生的细胞间通信的本质，2)揭示决定淋巴细胞和其他免疫细胞命运的外在和内在信号网络的最新理解，3)提高对免疫细胞命运和功能的代谢控制的认识，4)为新的研究人员和博士后和博士后学生的培训和指导提供一种形式。我们预计这次会议将改变该领域对免疫动员和执行的看法，并将有助于打破免疫学和其他学科之间的障碍。

Description (as provided by the applicant): Support is requested for a Keystone Symposia meeting entitled Emerging Topics in Immune System Plasticity: Cellular Networks, Metabolic Control, and Regeneration, organized by Steven L. Reiner, Erika L. Pearce and Yasmine Belkaid. The meeting will be held in Santa Fe, New Mexico from January 15 - 20, 2013. The immune system is a multi-cellular network that adapts to external threats. Immune cells cooperate with other defenses, such as barriers, to prevent breach and to reject invaders by selecting the right responses while inflicting minimal damage to the host. A key feature of the immune system is its fluidity and ability to traverse temporal and spatial boundaries. Furthermore, immune system dynamics involve cellular expansion, provisional cellular niches, altered transcription, and balancing differentiation with regeneration. This meeting will bring together diverse researchers to better understand how immune reactions are orchestrated to contend with the extrinsic information and metabolic demands of cellular differentiation, function, and homeostasis. The aims of the meeting are to 1) unveil the nature of cell-to-cell communication that occurs during different stages of the immune response, 2) reveal the latest understanding of extrinsic and intrinsic signaling networks that dictate lymphocyte and other immune cell fates, 3) increase awareness of metabolic control of immune cell fate and function, and 4) provide a format for the training and mentoring of new investigators and pre- and post- doctoral students. We anticipate that this meeting will alter the field's view of immune mobilization and execution, and will help to break barriers between immunology and other disciplines.