Serum pepsinogens of gastric cancer in Japan and China

在日本和中国都进行了详细的体检和调查，包括对生活方式的详细访谈，包括饮食习惯、医生检查和测量血压、尿检和血液检查。在日本，同时检测血清胃蛋白酶原、胃泌素和幽门螺杆菌抗体效价。研究对象为日本两个不同地区的4073人和748人，男性SMR分别为0.88和1.08，女性SMR分别为0.96和0.96。在H区胃癌死亡率(144.8/10万)中，我们研究了438人：M区中死亡率(105.7/10万)510人，L区低死亡率(36.3/10万)795人。分别从日本和中国的相应地区采集了74份和125份胃癌患者的血样和病理资料。对上述人群中胃癌死亡率为64.7/10万和71.0/10万的859名日本人和925名中国人的血清胃蛋白酶原I、II和胃泌素及抗幽门螺杆菌抗体效价进行了测定，日本与中国的PG I和PG I/II比值显著降低。反之，日本的PG II和胃泌素水平显著高于中国。另一方面，日本和中国的幽门螺杆菌阳性率虽因性别和年龄不同而不同，但分别为66.9%和69.2%。在日本和中国，与胃癌相关的生物标记物的分析现在都是常规的。

Medical examinations and investigations, which consisted of detailed interview on life-styles including eating habits, examination by a physician and measurement of blood pressure, urine test and blood examination were carried out in both Japan and China. Serum pepsinogens, gastrin, and anti-body titers to Helicobacter pylori were measured at the same time in Japan. Subjects in Japan were selected 4,073 people and 748 people from two different area of gastric cancer mortality in which SMR were 0.88 and 1.08 in male, but 0.96 and 0.96 in female. On the other hand, the populations in China from the three area with different gastric cancer mortality in Hebei province were studied as follows: In area H gastric cancer mortality (144.8/l00,000) we studied 438 people: area M, moderate mortality (105.7/l00,000) 510 people, and area L, low (36.3/100,000) 795 people. A total of 74 and 125 blood samples and pathological data of gastric cancer patients were collected from each corresponding areas in both Japan and China, respectively. Serum pepsinogens I, II and gastrin, and anti-body titers to H. pylori were measured to 859 subjects in Japan and 925 subjects in China selected from the above population who had almost same gastric cancer mortality rate 64.7/ 100,000 and 71.0/ 100,000, respectively.PG I and the ratio of PG I / II in Japan significantly decried compared with those in China. Couversely, PG II and gastrin in Japan significantly increased compared with those in China. On the other hand, although positivites to Helicobacter pylori in Japan and in China were different according to sex and age, they were 66.9% and 69.2% respectively. Analysis of biomarkers related to gastric cancer is now done routinely among gastric cancer patients in both Japan and China.