Serum pepsinogens of gastric cancer in Japan and China

在日本和中国进行了医疗检查和调查，其中包括对生活方式的详细访谈，包括饮食习惯、医生检查和测量血压、尿检和血液检查。同时测定血清胃蛋白酶原、胃泌素和幽门螺杆菌抗体滴度。在日本选取了4073人和748人分别来自两个不同的胃癌死亡率区域，其中男性SMR分别为0.88和1.08，女性SMR分别为0.96和0.96。另一方面，对河北省三个胃癌死亡率不同地区的人口进行了如下研究：H区胃癌死亡率（144.8/ 10万）438人，M区中等死亡率（105.7/ 10万）510人，L区低死亡率（36.3/10万）795人。在日本和中国的相应地区分别采集74份和125份胃癌患者的血液样本和病理资料。从胃癌死亡率为64.7/ 10万、71.0/ 10万的日本859例和中国925例患者中分别测定血清胃蛋白酶原I、II、胃泌素和幽门螺杆菌抗体滴度。与中国相比，日本PG I和PG I / II的比值显著下降。相反，PG II和胃泌素在日本与中国相比显著升高。另一方面，尽管日本和中国的幽门螺杆菌阳性率在性别和年龄上存在差异，但分别为66.9%和69.2%。在日本和中国，与胃癌相关的生物标志物分析现已在胃癌患者中常规进行。

Medical examinations and investigations, which consisted of detailed interview on life-styles including eating habits, examination by a physician and measurement of blood pressure, urine test and blood examination were carried out in both Japan and China. Serum pepsinogens, gastrin, and anti-body titers to Helicobacter pylori were measured at the same time in Japan. Subjects in Japan were selected 4,073 people and 748 people from two different area of gastric cancer mortality in which SMR were 0.88 and 1.08 in male, but 0.96 and 0.96 in female. On the other hand, the populations in China from the three area with different gastric cancer mortality in Hebei province were studied as follows: In area H gastric cancer mortality (144.8/l00,000) we studied 438 people: area M, moderate mortality (105.7/l00,000) 510 people, and area L, low (36.3/100,000) 795 people. A total of 74 and 125 blood samples and pathological data of gastric cancer patients were collected from each corresponding areas in both Japan and China, respectively. Serum pepsinogens I, II and gastrin, and anti-body titers to H. pylori were measured to 859 subjects in Japan and 925 subjects in China selected from the above population who had almost same gastric cancer mortality rate 64.7/ 100,000 and 71.0/ 100,000, respectively.PG I and the ratio of PG I / II in Japan significantly decried compared with those in China. Couversely, PG II and gastrin in Japan significantly increased compared with those in China. On the other hand, although positivites to Helicobacter pylori in Japan and in China were different according to sex and age, they were 66.9% and 69.2% respectively. Analysis of biomarkers related to gastric cancer is now done routinely among gastric cancer patients in both Japan and China.