Scientific Project 2: HIV AIDS Defining molecular signatures in humans following vaccination that can inform pathways to protective immunity against HIV-1 infection
Scientific Project 2: HIV AIDS Defining molecular signatures in humans following vaccination that can inform pathways to protective immunity against HIV-1 infection
批准号:
10419585
负责人:
Margaret Juliana McElrath
金额:
$20.45万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
未结题
起止时间:
2017-07-19 至 2027-04-30
关键词:
2019-nCoVAIDS preventionAcquired Immunodeficiency SyndromeActive ImmunizationAdjuvantAfricaAntibodiesAntibody-mediated protectionAntigenic SpecificityAntigensArchitectureAreaB cell repertoireB-LymphocytesBenchmarkingBiological AssayBlood CirculationBone MarrowCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCell physiologyCellsData SourcesDevelopmentEpidemicEpitopesEvaluationEvolutionFormulationGenerationsGoalsHIVHIV InfectionsHIV vaccineHIV-1Helper-Inducer T-LymphocyteHumanImmuneImmune responseImmunityImmunizationInfectionInvestigationKnowledgeLibrariesMalariaMeasuresMetadataMolecularMolecular ProfilingParticipantPathway interactionsPeripheralPhasePhenotypePlacebosPlasma CellsPopulationPopulation HeterogeneityPreventionPreventiveProteomicsProtocols documentationRegimenSARS-CoV-2 infectionSafetySerologySourceSystemT cell receptor repertoire sequencingT cell responseT-Cell Immunologic SpecificityT-Cell ReceptorT-LymphocyteTechnologyTestingTissuesTranslatingVaccinationVaccine DesignVaccinesViraladaptive immune responseanalytical tooldraining lymph nodeefficacy trialin vivoinsightlymph nodesmultimodalityneutralizing antibodynovelpolyclonal antibodypreventprimary endpointresponsestudy populationsuccessvaccine efficacyvaccine trial
中文摘要
HIPC3项目2的总体目标是识别HIV-1诱导的人类分子特征
可能与预防艾滋病毒-1相关的疫苗和佐剂制剂
在不同的人群中感染。我们建议的调查将集中在以下三个领域
需要关键洞察力:1)全面评估和比较质量和
可溶性AFP免疫后免疫应答的效力和持久性增强
用不同佐剂配制的类天然Env三聚体,2)淋巴结生发的评价
细胞活性和B细胞功能及表型有可能启动
HIV-1广泛的中和抗体,以及3)先进的高通量系统来询问
接种疫苗后的HIV特异性T细胞谱系和识别可能与
部分有效疫苗试验中的免疫保护。将在这些研究中嵌入
对独特组织来源和不同人群中的反应特征进行精选分析。
这些研究将通过探测天生的和
人类的适应性免疫反应达到了前所未有的水平。
英文摘要
The overall goal of HIPC3 Project 2 is to identify human molecular signatures induced by HIV-1
vaccines and adjuvant formulations that are of potential relevance to protection against HIV-1
infection in diverse populations. Our proposed investigations will focus on three areas where
critical insights are needed: 1) comprehensive assessment and comparison of the quality and
enhanced potency and durability of immune responses following immunization with a soluble
native-like Env trimer formulated with different adjuvants, 2) evaluation of lymph node germinal
cell activities and B cell function and phenotype that have the potential to initiate development of
HIV-1 broad neutralizing antibodies, and 3) advance high-throughput systems to interrogate the
HIV-specific T cell repertoire following vaccination and identify profiles that may associate with
immune protection in partially efficacious vaccine trials. Embedded in these studies will be
selected analyses of response signatures in unique tissue sources and in diverse populations.
These investigations will accelerate progress toward an effective vaccine by probing innate and
adaptive immune responses at an unprecedented level in humans.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
CoVPN 3003 A Phase 3 Study to Assess the Efficacy and Safety of Ad26.COV2.S for the Prevention of SARS-CoV-2-mediated COVID-19 in Adults Aged 18 Years and Older LC 3
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批准号:10570748
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项目类别:
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资助金额:$58.69万
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财政年份:2022
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负责人:Margaret Juliana McElrath
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依托单位:
HVTN 405/HPTN 1901 (CoVPN) Characterizing SARS-CoV-2-specific Immunity in Convalescent Individuals: LC 3
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批准号:10570806
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项目类别:
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资助金额:$132.48万
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财政年份:2022
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负责人:Margaret Juliana McElrath
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依托单位:
CoVPN 3004 - A Phase 3, Randomized, Observer-Blinded, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Immunogenicity of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine Lab
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批准号:10322580
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项目类别:
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资助金额:$1498.01万
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财政年份:2021
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负责人:Margaret Juliana McElrath
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依托单位:
HVTN 405/HPTN 1901 Characterizing SARS-CoV-2-specific immunity in convalescent individuals: LC
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批准号:10165321
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项目类别:
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资助金额:$2995.23万
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财政年份:2020
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负责人:Margaret Juliana McElrath
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依托单位:
SARS-CoV-2 testing at the Seattle Vaccine and Prevention CRS (30331)
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批准号:10166485
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项目类别:
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资助金额:$29.94万
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财政年份:2020
-
负责人:Margaret Juliana McElrath
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依托单位:
Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization - Clinical Core
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批准号:10419582
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项目类别:
-
资助金额:$17.68万
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财政年份:2017
-
负责人:Margaret Juliana McElrath
-
依托单位:
Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization
-
批准号:10419580
-
项目类别:
-
资助金额:$207.15万
-
财政年份:2017
-
负责人:Margaret Juliana McElrath
-
依托单位:
Immune Responses to Malaria and HIV Infection and Immunization - Clinical Core
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批准号:10198679
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项目类别:
-
资助金额:$16.28万
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财政年份:2017
-
负责人:Margaret Juliana McElrath
-
依托单位:
Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization - Clinical Core
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批准号:10631089
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项目类别:
-
资助金额:$18.52万
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财政年份:2017
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负责人:Margaret Juliana McElrath
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依托单位:
Immune responses to HIV virus immunization - Project 2
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批准号:10198682
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项目类别:
-
资助金额:$59.64万
-
财政年份:2017
-
负责人:Margaret Juliana McElrath
-
依托单位:
Scientific Project 2: HIV AIDS Defining molecular signatures in humans following vaccination that can inform pathways to protective immunity against HIV-1 infection
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批准号:10631105
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项目类别:
-
资助金额:$13.48万
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财政年份:2017
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负责人:Margaret Juliana McElrath
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依托单位:
Immune Responses to Malaria, HIV and SARS-CoV-2 Infection and Immunization
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批准号:10631086
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项目类别:
-
资助金额:$210.0万
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财政年份:2017
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负责人:Margaret Juliana McElrath
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依托单位:
HIV-1 Cellular Immunity in Exposed Seronegatives
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批准号:8086448
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项目类别:
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资助金额:$18.49万
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财政年份:2010
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负责人:Margaret Juliana McElrath
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依托单位:
Immune Profile and Network Analysis of Malaria Infection and Vaccination
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批准号:9129262
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项目类别:
-
资助金额:$24.63万
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财政年份:2010
-
负责人:Margaret Juliana McElrath
-
依托单位:
Immune Profile and Network Analysis of Malaria Infection and Vaccination
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批准号:8150942
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项目类别:
-
资助金额:$51.81万
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财政年份:2010
-
负责人:Margaret Juliana McElrath
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依托单位:
Immune Signatures Associated with Plasmodium falciparum Control Following Natural
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批准号:7994286
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项目类别:
-
资助金额:$28.66万
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财政年份:2010
-
负责人:Margaret Juliana McElrath
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依托单位:
Immune Profile and Network Analysis of Malaria Infection and Vaccination
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批准号:7977154
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项目类别:
-
资助金额:$52.3万
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财政年份:2010
-
负责人:Margaret Juliana McElrath
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依托单位:
Immune Profile and Network Analysis of Malaria Infection and Vaccination
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批准号:8527698
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项目类别:
-
资助金额:$48.2万
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财政年份:2010
-
负责人:Margaret Juliana McElrath
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依托单位:
Immune Profile and Network Analysis of Malaria Infection and Vaccination
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批准号:8316314
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项目类别:
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资助金额:$51.28万
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财政年份:2010
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负责人:Margaret Juliana McElrath
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依托单位:
Seattle-Lausanne Clinical Trials Unit
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批准号:10531278
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项目类别:
-
资助金额:$185.72万
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财政年份:2007
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负责人:Margaret Juliana McElrath
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依托单位:
海外基金