Golem: A disruptive platform to access and interactively analyse genetic data

Golem：访问和交互式分析遗传数据的颠覆性平台

• 批准号: 10001080
• 金额: $ 36.79万
• 依托单位: OMECU LIMITED
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10001080
• 关键词: Golem; disruptive; platform; access; interactively

Being able to extract useful information from genetic and health data is a key challenge for the next decade.Human genomic data is doubling in size every seven months and may soon exceed other Big Data generators such as astronomy, YouTube and Twitter. Although this data is revolutionising medicine and development of new therapeutics and diagnostics, reaching the full potential of this substantial investment relies on our ability to unlock clinically actionable knowledge from it. The key to this is ensuring data access and analysis capabilities are democratised over a range of researchers and institutions with different capabilities, whilst ensuring individual level data is kept safe. However, obstacles to this remain, owing to the data's unprecedented size, complexity, and restricted access (relating to privacy concerns, economic interests, research limitations, and multi-institutional data fragmentation).This project will lead to the development of a disruptive commercial platform changing how data is accessed and how value is extracted from it. This will have impacts in several areas, including:* Increasing efficiency of drug development.* Reducing NHS expenditure, by reducing drug side effects and overall improvement of personalised medicine.* Increasing productivity of high tech jobs.* Overall improvement of academic research in genetics. Including helping to understand why COVID-19 differently impacts different people.* Reducing carbon footprint in big datacenters through the use of much more efficient computing algorithms.* Empowering the individuals to control what happens with their data.If successful, this project will contribute to the UK's ambitions of leading the field of genetics and creating the right fabric for developing an important, high-tech industry for the next decade.This is a highly scalable project targeting a rapidly growing international market at the very important intersection between computer science, genetic and epidemiological data analysis, and human health. It is also timely, addressing an important challenge that is within the government four Grand Challenges as well as many objectives highlighted in the Innovate UK Horizons Tool. Overall, if successful in our ambitions, we could significantly contribute to the UK's aspirations as a relevant player offering solutions for the next decade's forthcoming challenges whilst strengthening and supporting GDP, develop and attract international talent, and globally create high quality jobs.

能够从基因和健康数据中提取有用的信息是未来十年的一个关键挑战。人类基因组数据的规模每七个月就翻一番，可能很快就会超过其他大数据生成器，如天文学，YouTube和Twitter。尽管这些数据正在彻底改变医学和新疗法及诊断的发展，但要充分发挥这一巨大投资的潜力，有赖于我们从中释放临床可操作知识的能力。关键是确保数据访问和分析能力在一系列具有不同能力的研究人员和机构中实现民主化，同时确保个人层面的数据安全。然而，由于数据的规模、复杂性和访问限制，这方面的障碍仍然存在（与隐私问题、经济利益、研究限制和多机构数据碎片化有关）。该项目将导致颠覆性商业平台的开发，改变数据的访问方式和从中提取价值的方式。这将在多个领域产生影响，包括：* 提高药物开发效率。*通过减少药物副作用和全面改善个性化医疗来减少NHS支出。提高高科技工作的生产力。*全面提高遗传学学术研究水平。包括帮助理解为什么COVID-19对不同的人产生不同的影响。*通过使用更高效的计算算法减少大型企业的碳足迹。*使个人能够控制他们的数据发生什么。如果成功，这个项目将有助于英国领导遗传学领域的雄心，并为未来十年发展一个重要的高科技产业创造合适的结构。这是一个高度可扩展的项目，目标是在计算机科学，遗传学和流行病学数据分析之间非常重要的交叉点上快速增长的国际市场，和人类健康。这也是及时的，解决了政府内部的一个重要挑战，即四大挑战以及创新英国视野工具中强调的许多目标。总的来说，如果我们的雄心壮志取得成功，我们可以为英国的愿望做出重大贡献，成为一个相关的参与者，为未来十年即将到来的挑战提供解决方案，同时加强和支持GDP，发展和吸引国际人才，并在全球创造高质量的就业机会。