Multiscale models in immuno-epidemiology

免疫流行病学中的多尺度模型

• 批准号: DP210101920
• 负责人: Prof James McCaw
• 金额: $ 27.43万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-04-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101920
• 关键词: Multiscale; models; immuno; epidemiology

The spread of a pathogen (for example, a virus or bacteria) through a population is a multi-scale phenomena, influenced by factors acting at both the population and within-host scales. At the population scale, transmission is influenced by how infectious an infected host is. Infectiousness in turn depends on the balance between pathogen replication within the host and immune/drug control mechanisms. This project aims to develop new mathematical frameworks for simultaneously modelling these two scales. This will provide a platform for the rigorous study of complex biological interactions - such as the emergence and combat of drug-resistance - that shape society's ability to control infectious diseases in human, animal and plant systems.

病原体（例如病毒或细菌）在种群中的传播是一种多尺度现象，受到种群和宿主内尺度因素的影响。在人口规模上，传播受受感染宿主的传染性影响。而致病性又取决于宿主内病原体复制与免疫/药物控制机制之间的平衡。该项目旨在开发新的数学框架，同时模拟这两个尺度。这将为严格研究复杂的生物相互作用提供一个平台，例如耐药性的出现和对抗，这些相互作用塑造了社会控制人类、动物和植物系统中传染病的能力。