(PQD6) Hypothalamic Inflammation in the Initiation of Cachexia
(PQD6) 恶病质引发的下丘脑炎症
基本信息
- 批准号:8845181
- 负责人:
- 金额:$ 42.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-07-01 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdrenal GlandsAnorexiaBehaviorBehavioralBody Weight decreasedCachexiaCancer PatientCatabolismCessation of lifeChronicChronic DiseaseClinicalCollaborationsCommunicable DiseasesCytokine ReceptorsDataDevelopmentDiseaseEventFatigueFatty acid glycerol estersGenesGlycoproteinsGoalsHealthHomeostasisHypothalamic structureInflammationInflammatoryInterferonsInterventionKidney FailureLaboratoriesLeukocytesLifeLinkLymphocyteMaintenanceMalignant NeoplasmsMalnutritionMetabolicMetabolismMicrogliaModelingMorbidity - disease rateMuscleMyelogenousNeuroendocrinologyNeuronsNeurosciencesOutputPathologyPatientsPeripheralPharmacologic SubstancePlayPopulationPublishingQuality of lifeResearchResearch DesignRiskRoleSeveritiesSignal PathwaySignal TransductionTherapeutic InterventionWorkcancer cachexiachemokinehypocretinincreased appetitelean body masslipid metabolismmortalityresponsesignal processingtumor progressionwasting
项目摘要
DESCRIPTION (provided by applicant): Cachexia, or disease-associated wasting, is a common occurrence in cancer, renal failure, and infectious disease. This devastating state of malnutrition is brought about by a synergistic combination of a decrease in appetite and an increase in metabolism of fat and lean body mass. The severity of cachexia in many illnesses is the primary determining factor in both quality of life, and in eventual mortality. Other illness-induced morbidities including lethargy also compromise the ability of patients to recover from potentially life-saving or extending interventions, and diminish the motivational drive to aggressively battle the condition. Although cachexia in chronic disease was described more than two thousand years ago, the central mechanisms underlying this disorder of energy homeostasis are poorly understood. Furthermore, there is currently no effective pharmaceutical treatment. Our laboratory has dedicated the last decade to unraveling the basic neuroscience of cachexia. In this proposal, we will focus on understanding the scope and mechanism by which peripheral inflammatory insults are received, amplified, and maintained by the hypothalamus. The significance of this proposal resides in its unique combination of our historical focus on neuroendocrinology and behavior, with new collaborations and efforts directed at understanding proximal neuroinflammatory events. The long-term goal of our research is to gain mechanistic understanding of the acute illness response and how it is transitioned into chronic inflammation-associated cachexia in order to develop more effective therapeutic interventions.
描述(由申请人提供):恶病质,或与疾病相关的消瘦,是癌症、肾功能衰竭和传染病的常见症状。这种毁灭性的营养不良状态是食欲下降和脂肪代谢和瘦体重增加的协同作用造成的。在许多疾病中,恶病质的严重程度是生活质量和最终死亡率的主要决定因素。其他由疾病引起的疾病,包括嗜睡,也损害了患者从潜在的挽救生命或延长干预措施中恢复的能力,并削弱了积极与这种疾病作斗争的动力。虽然慢性疾病中的恶病质早在两千多年前就被描述了,但这种能量平衡失调的核心机制却鲜为人知。此外,目前还没有有效的药物治疗。在过去的十年里,我们的实验室致力于解开恶病质的基础神经科学。在这项提案中,我们将重点了解下丘脑接受、放大和维持外周炎性损害的范围和机制。这项建议的意义在于它独特地结合了我们对神经内分泌学和行为的历史关注,以及针对了解近端神经炎性事件的新合作和努力。我们研究的长期目标是从机制上了解急性疾病的反应以及它是如何转变为慢性炎症相关的恶病质的,以便开发更有效的治疗干预措施。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniel L. Marks其他文献
Serum leptin levels, hepatic leptin receptor transcription, and clinical predictors of non-alcoholic steatohepatitis in obese bariatric surgery patients
肥胖减肥手术患者的血清瘦素水平、肝脏瘦素受体转录和非酒精性脂肪性肝炎的临床预测因子
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
D. Le;Daniel L. Marks;E. Lyle;Christopher L. Corless;B. Diggs;B. A. Jobe;Tom S. Kay;Clifford W. Deveney;Bruce M. Wolfe;C. Roberts;Robert W. O’Rourke - 通讯作者:
Robert W. O’Rourke
Rapid prototyping lightweight millimeter wave antenna and waveguide with copper plating
快速原型制作轻型毫米波天线和镀铜波导
- DOI:
10.1109/irmmw-thz.2015.7327539 - 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Ruoyu Zhu;Daniel L. Marks - 通讯作者:
Daniel L. Marks
Daniel L. Marks的其他文献
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{{ truncateString('Daniel L. Marks', 18)}}的其他基金
PQ6: Therapeutic approaches for autonomic and neuroendocrine dysfunction in cancer cachexia
PQ6:癌症恶病质自主神经和神经内分泌功能障碍的治疗方法
- 批准号:
10303658 - 财政年份:2021
- 资助金额:
$ 42.24万 - 项目类别:
PQ6: Lipocalin-2 as a therapeutic target for prevention of cancer cachexia
PQ6:Lipocalin-2 作为预防癌症恶病质的治疗靶点
- 批准号:
10379260 - 财政年份:2021
- 资助金额:
$ 42.24万 - 项目类别:
PQ6: Lipocalin-2 as a therapeutic target for prevention of cancer cachexia
PQ6:Lipocalin-2 作为预防癌症恶病质的治疗靶点
- 批准号:
10152268 - 财政年份:2021
- 资助金额:
$ 42.24万 - 项目类别:
PQ6: Therapeutic approaches for autonomic and neuroendocrine dysfunction in cancer cachexia
PQ6:癌症恶病质自主神经和神经内分泌功能障碍的治疗方法
- 批准号:
10490306 - 财政年份:2021
- 资助金额:
$ 42.24万 - 项目类别:
Exosomes as Endocrine Signaling Molecules in Cancer Cachexia
外泌体作为癌症恶病质的内分泌信号分子
- 批准号:
9906180 - 财政年份:2018
- 资助金额:
$ 42.24万 - 项目类别:
Exosomes as Endocrine Signaling Molecules in Cancer Cachexia
外泌体作为癌症恶病质的内分泌信号分子
- 批准号:
10171402 - 财政年份:2018
- 资助金额:
$ 42.24万 - 项目类别:
Exosomes as Endocrine Signaling Molecules in Cancer Cachexia
外泌体作为癌症恶病质的内分泌信号分子
- 批准号:
10394305 - 财政年份:2018
- 资助金额:
$ 42.24万 - 项目类别:
(PQD6) Hypothalamic Inflammation in the Initiation of Cachexia
(PQD6) 恶病质引发的下丘脑炎症
- 批准号:
8994016 - 财政年份:2014
- 资助金额:
$ 42.24万 - 项目类别:
(PQD6) Hypothalamic Inflammation in the Initiation of Cachexia
(PQD6) 恶病质引发的下丘脑炎症
- 批准号:
9079439 - 财政年份:2014
- 资助金额:
$ 42.24万 - 项目类别:
(PQD6) Hypothalamic Inflammation in the Initiation of Cachexia
(PQD6) 恶病质引发的下丘脑炎症
- 批准号:
8680933 - 财政年份:2014
- 资助金额:
$ 42.24万 - 项目类别:
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