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Intervention to reduce drug use and HIV incidence among high PrEP priority partnered YMSM

减少 PrEP 重点合作伙伴 YMSM 中吸毒和艾滋病毒发病率的干预措施

基本信息

批准号：
10152563
负责人：
Tyrel J Starks
金额：
$ 77.84万
依托单位：
HUNTER COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10152563
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Address Adherence Age Agreement Attention Behavior Therapy Behavioral Biological Biological Assay Biological Markers Blood Centers for Disease Control and Prevention (U.S.)Collection Communication Couples Data Development Dose Drug Targeting Drug usage Education Epidemic Face Funding Future Gender Goals HIV HIV Infections HIV Seronegativity HIV Seropositivity HIV risk Hair Heterosexuals Incidence Individual Infection Intervention Intervention Studies Interview Joints Link Logistics Measures Mediating Modeling Motivation Nature Participant Pharmaceutical Preparations Prevention Prevention strategy Provider Public Health Randomized Recommendation Reporting Research Research Personnel Risk Risk Behaviors Risk Reduction Behavior Sampling Sampling Biases Services Sex Behavior Sexual Health Spottings Structure of nail of finger Tenofovir United States United States National Institutes of Health Vulnerable Populations Work acceptability and feasibility attentional control base condomless anal sex control trial cost effectiveness implementation study effectiveness trial efficacy evaluation efficacy testing eligible participant experience follow up assessment group intervention health care settings innovation interest intervention effect men men who have sex with men motivational enhancement therapy multimodality novel pre-exposure prophylaxis prevent prevention service primary outcome psychoeducation recruit response service intervention sex skills skills training substance use theories transmission process uptake young man young men who have sex with men

项目摘要

Project Summary CDC recommendations identify MSM in non-monogamous relationships and those in relationships with an HIV positive partner as candidates for PrEP. Estimates suggest as many as 79% of new HIV infections among young MSM (YMSM; ages 18-29) are transmitted between main partners. Drug use is an established correlate of HIV transmission risk. For partnered men, relational factors (e.g., sexual agreements) contextualize drug use and both drug use and sexual agreements predict receptivity to PrEP. Together, these findings point to the need for integrated intervention services – targeting drug use and sexual health –tailored for partnered YMSM. Such services are essential to addressing the HIV epidemic in the US. In response, our team has developed a 4-session MI-based intervention targeting PrEP uptake/adherence, HIV TRB, and drug use among partnered YMSM. PARTNER (Prevention And Risk: Treatment with a New Emphasis on Relationships) is delivered to individual YMSM in relationships (not couples), which enhances the scalability of the proposed intervention. Our preliminary pilot work has established the acceptability and feasibility of PARTNER. The primary goal of the current study is to test the efficacy of PARTNER relative to an attention-matched educational control condition used in previously funded NIH studies with HIV-negative YMSM. We propose to recruit 240 HIV-negative partnered YMSM who report recent drug use and sexual behavior consistent with CDC guidance for PrEP candidacy into a randomized control trial. As part of a secondary aim, this project seeks to enhance the range of biological measures for PrEP adherence currently available. The field standard for assessing tenofovir metabolites is dried blood spot assay; however, fingernail assay has high acceptability and lower cost. We propose to validate fingernail samples for PrEP adherence by correlating results obtained from fingernail samples with dried blood spot data. The study team is led by Dr. Tyrel J. Starks (PI), a new investigator with substantial experience in the study of relationship factors associated with sexual health and MSM in relationships. He has collaborated on numerous projects examining the nature of sexual agreements and their association with substance use and HIV transmission risk behavior. He is supported by a study team which includes Dr. Jeffrey Parsons, the PI of multiple intervention studies targeting sexual health and substance use. He is also joined by Dr. Monica Gandhi, an expert in biological assessment for PrEP adherence who has pioneered the use of novel matrices in previous NIH- funded studies. The team brings extensive experience in behavioral intervention research, relationship research, and biomedical assessment.

项目摘要疾控中心的建议确定了非一夫一妻制关系中的MSM和与HIV阳性伴侣作为PrEP候选对象的关系。据估计，由于年轻男男性接触者(YMSM；18-29岁)中79%的新艾滋病毒感染是在主要合作伙伴。吸毒是艾滋病毒传播风险的既定相关性。对于有伴侣的男人来说，关系因素(例如性协议)使药物使用和药物使用和性协议预示着人们对PrEP的接受度。总而言之，这些发现表明有必要针对毒品使用和性健康的综合干预服务-为合作伙伴量身定做基督教青年会。这些服务对于解决美国的艾滋病毒流行至关重要。作为回应，我们的团队开发了一种针对PrEP的4次基于MI的干预结伴青年男性接触者的吸食/依从性、HIV TRB和药物使用情况。合作伙伴(预防和风险：以关系为新重点的治疗)在#年交付给个别YMSM 关系(而不是夫妻)，这增强了拟议干预措施的可扩展性。我们的初步试点工作已经确定了合作伙伴的可接受性和可行性。初级阶段目前这项研究的目的是测试伴侣相对于注意力匹配的伴侣的有效性以前资助的NIH HIV阴性YMSM研究中使用的教育控制条件。我们建议招募240名艾滋病毒阴性的有伴侣的基督教男同性恋者，他们报告最近吸毒和符合CDC指南的性行为将PrEP候选纳入随机对照审判。作为次要目标的一部分，该项目寻求扩大生物多样性的范围目前可用的遵守PrEP的措施。替诺福韦的现场评价标准代谢物为干血斑法，而指甲法具有较高的可接受性和更低的成本。我们建议通过关联结果来验证指甲样本的PrEP依从性从有干血迹数据的指甲样本中获得。研究小组由Tyrel J.Starks(Pi)博士领导，他是一名具有丰富经验的新研究员在研究与性健康相关的关系因素和男男性接触者的关系中。他曾在多个项目中合作检验性协议的性质和他们的与药物使用和艾滋病毒传播危险行为有关。他得到了一项研究的支持包括杰弗里·帕森斯博士在内的团队，他是针对性行为的多项干预研究的PI 健康和物质使用。生物专家莫妮卡·甘地博士也加入了他的行列。对在以前的NIH中率先使用新矩阵的PrEP遵守情况进行评估- 资助的研究。该团队在行为干预研究方面拥有丰富的经验，关系研究和生物医学评估。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Psychosocial and Culturally-Specific Factors Related to Intimate Partner Violence Victimization among a Sample of Latino Sexual Minority Cis Men in the U.S.

DOI：
10.1177/08862605211072167
发表时间：
2022-12
期刊：
JOURNAL OF INTERPERSONAL VIOLENCE
影响因子：
2.5
作者：
Robles, Gabriel;Bosco, Stephen C.;Cardenas, Iris;Hostetter, Joletta;Starks, Tyrel J.
通讯作者：
Starks, Tyrel J.

Keeps me awake at night: The potential of the COVID-19 pandemic to affect sleep quality among sexual minority men in the U.S.A.

让我在晚上保持清醒：美国199大流行的潜力影响了美国的性少数族裔男性的睡眠质量。