Evaluating the efficacy of annual CHTC retesting among male couples at high risk of HIV infection

评估 HIV 感染高危男性夫妇每年进行 CHTC 重新检测的效果

• 批准号: 10700394
• 负责人: Tyrel J Starks
• 金额: $ 10.76万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700394
• 关键词: 4-hydroxybutyric acid; AIDS prevention; Accounting; Address; Adherence; Age; Agreement; Amphetamines; Appointment; Bisexual; COVID-19; Cannabis; Chlamydia Infections; Cocaine; Communication; Consent; Counseling; Couples; Data; Drug usage; Enrollment; Feedback; Gays; Gonorrhea; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Human immunodeficiency virus test; Individual; Infection; Intervention; Investments; Ketamine; Link; Measures; Mediating; Mediator; Modeling; Nature; Nitrates; Outcome; Parents; Participant; Population; Prevention; Prevention strategy; Protocols documentation; Public Health; Randomized; Recommendation; Recording of previous events; Reporting; Research; Rest; Risk; Risk Behaviors; Sampling; Syphilis; Testing; Time; Training; United States National Institutes of Health; aged; binge drinking; condomless anal sex; coping; design; ecstasy; efficacy evaluation; efficacy testing; emerging adult; follow up assessment; follow-up; high risk; implementation research; intervention effect; male couples; men; men who have sex with men; motivational enhancement therapy; post intervention; pre-exposure prophylaxis; response; sex; sexual HIV transmission; sexual minority men; skills; substance use; theories; transmission process; uptake

Project Summary Sexual minority men (SMM), including gay, bisexual, and other men who have sex with men, account for 69% of new HIV infections in the US. Primary partnerships have been linked to up to as many as 68% of new HIV infections among SMM. This rate is highest among emerging adult SMM (aged 18-29), where estimates suggest 79% to 84% of HIV infections are transmitted by primary partners. In response to the concerns posed by primary partner transmission, couples HIV testing and counseling (CHTC) has been acknowledged as an established HIV prevention strategy. During CHTC, couples complete HIV testing and prevention planning together. Current CHTC guidance includes the recommendation that all couples routinely retest every 6 to 12 months. Despite the standard nature of this retesting recommendation, no study has empirically evaluated the effects of CHTC retesting. This competitive revision capitalizes on NIH investment in the parent study (DA050508) to obtain the first outcomes data on annual CHTC retesting. DA050508 is currently enrolling 240 male couples living in the US in which at least one partner: is age 17 to 29; is HIV-negative; and reports recent (past 30 days) drug use (e.g., cannabis, cocaine/crack, amphetamines, ecstasy, gamma hydroxybutyric acid, ketamine, or nitrates), and recent (past 3 months) sexual HIV transmission risk behavior. As part of their participation in DA050508, all couples complete a CHTC session after baseline. They subsequently complete follow-up assessments at 3, 6, 9, and 12-months post- baseline. The purpose of this revision is to evaluate the benefits associated with CHTC resting. After their 12- month follow-up, those participants who remain in the same relationship they were in at the time of their baseline will be offered the opportunity to continue in the components proposed in this revision. Those who consent will be randomized to either complete a second session of CHTC or to a comparison condition in which both partners receive a routine individual HIV test. HIV positive partners in serodiscordant couples randomized to the control condition will receive information about ART adherence and U=U. Given potential attrition and rates of relationship dissolution, we anticipate randomizing 200 couples (80% of the original sample). Follow-up assessments will be conducted 3 and 6 months after retesting (15 and 18 months after the participants’ original baseline appointment).

项目摘要 性少数男性（SMM），包括同性恋，双性恋和其他与男性发生性关系的男性， 在美国，69%的新艾滋病毒感染者。初级伙伴关系与多达68%的 SMM中的新艾滋病毒感染。这一比率在新兴的成年SMM（18-29岁）中最高， 据估计，79%至84%的艾滋病毒感染是由主要伴侣传播的。响应于 主要伴侣传播、夫妇艾滋病毒检测和咨询（CHTC）引起的担忧， 这是一项公认的艾滋病毒预防战略。在CHTC期间，夫妇完成艾滋病毒检测， 预防规划结合起来。 目前的CHTC指南包括建议所有夫妇定期每6至12天重新测试一次 个月尽管这一重新测试建议的标准性质，没有研究经验性地评估 CHTC重新测试的影响。这项竞争性修订利用了NIH在母研究中的投资 （DA 050508）以获得年度CHTC复检的第一个结果数据。 DA 050508目前招募了240对居住在美国的男性夫妇，其中至少有一方年龄： 17至29岁; HIV阴性;并报告最近（过去30天）使用药物（例如，大麻可卡因/快克 安非他明、摇头丸、γ-羟丁酸、氯胺酮或硝酸盐），以及最近（过去3个月）的性行为 HIV传播危险行为。作为参与DA 050508的一部分，所有夫妇都要完成一项CHTC 基线后的会话。他们随后在术后3、6、9和12个月完成随访评估。 基线。 本次修订的目的是评估与CHTC休息相关的益处。在他们12岁之后- 一个月的随访，那些仍然保持着他们在他们的时间相同的关系的参与者 基线将有机会在本修订版中提议的组成部分中继续使用。的人 知情同意书将随机分配至完成第二次CHTC治疗或接受比较条件， 夫妻双方都要接受常规的艾滋病毒检测。血清不一致夫妇中的艾滋病毒阳性伴侣 随机分配到对照条件的患者将接收关于ART依从性的信息并且U=U。给定电位 在研究中，我们预计将随机抽取200对夫妇（80%的夫妇）， 样品）。随访评估将在重新测试后3个月和6个月（测试后15个月和18个月）进行。 参与者的原始基线预约）。

项目成果

A full-factorial randomized controlled trial of adjunct couples HIV testing and counseling components addressing drug use and communication skills among sexual minority male couples.

• DOI: 10.1186/s12889-021-12208-3
• 发表时间: 2021-11-24
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Starks TJ;D Kyre K;B Cowles C;Castiblanco J;Washington C;N Parker J;M Kahle E;Stephenson R
• 通讯作者: Stephenson R