Evaluating the efficacy of annual CHTC retesting among male couples at high risk of HIV infection

评估 HIV 感染高危男性夫妇每年进行 CHTC 重新检测的效果

• 批准号: 10700394
• 负责人: Tyrel J Starks
• 金额: $ 10.76万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700394
• 关键词: 4-hydroxybutyric acid; AIDS prevention; Accounting; Address; Adherence; Age; Agreement; Amphetamines; Appointment; Bisexual; COVID-19; Cannabis; Chlamydia Infections; Cocaine; Communication; Consent; Counseling; Couples; Data; Drug usage; Enrollment; Feedback; Gays; Gonorrhea; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Human immunodeficiency virus test; Individual; Infection; Intervention; Investments; Ketamine; Link; Measures; Mediating; Mediator; Modeling; Nature; Nitrates; Outcome; Parents; Participant; Population; Prevention; Prevention strategy; Protocols documentation; Public Health; Randomized; Recommendation; Recording of previous events; Reporting; Research; Rest; Risk; Risk Behaviors; Sampling; Syphilis; Testing; Time; Training; United States National Institutes of Health; aged; binge drinking; condomless anal sex; coping; design; ecstasy; efficacy evaluation; efficacy testing; emerging adult; follow up assessment; follow-up; high risk; implementation research; intervention effect; male couples; men; men who have sex with men; motivational enhancement therapy; post intervention; pre-exposure prophylaxis; response; sex; sexual HIV transmission; sexual minority men; skills; substance use; theories; transmission process; uptake

Project Summary Sexual minority men (SMM), including gay, bisexual, and other men who have sex with men, account for 69% of new HIV infections in the US. Primary partnerships have been linked to up to as many as 68% of new HIV infections among SMM. This rate is highest among emerging adult SMM (aged 18-29), where estimates suggest 79% to 84% of HIV infections are transmitted by primary partners. In response to the concerns posed by primary partner transmission, couples HIV testing and counseling (CHTC) has been acknowledged as an established HIV prevention strategy. During CHTC, couples complete HIV testing and prevention planning together. Current CHTC guidance includes the recommendation that all couples routinely retest every 6 to 12 months. Despite the standard nature of this retesting recommendation, no study has empirically evaluated the effects of CHTC retesting. This competitive revision capitalizes on NIH investment in the parent study (DA050508) to obtain the first outcomes data on annual CHTC retesting. DA050508 is currently enrolling 240 male couples living in the US in which at least one partner: is age 17 to 29; is HIV-negative; and reports recent (past 30 days) drug use (e.g., cannabis, cocaine/crack, amphetamines, ecstasy, gamma hydroxybutyric acid, ketamine, or nitrates), and recent (past 3 months) sexual HIV transmission risk behavior. As part of their participation in DA050508, all couples complete a CHTC session after baseline. They subsequently complete follow-up assessments at 3, 6, 9, and 12-months post- baseline. The purpose of this revision is to evaluate the benefits associated with CHTC resting. After their 12- month follow-up, those participants who remain in the same relationship they were in at the time of their baseline will be offered the opportunity to continue in the components proposed in this revision. Those who consent will be randomized to either complete a second session of CHTC or to a comparison condition in which both partners receive a routine individual HIV test. HIV positive partners in serodiscordant couples randomized to the control condition will receive information about ART adherence and U=U. Given potential attrition and rates of relationship dissolution, we anticipate randomizing 200 couples (80% of the original sample). Follow-up assessments will be conducted 3 and 6 months after retesting (15 and 18 months after the participants’ original baseline appointment).

项目摘要 性少数男性(SMM)，包括同性恋、双性恋和其他与男性发生性关系的男性，占 对美国69%的新艾滋病毒感染者来说。初级合作伙伴关系与高达68%的 SMM中出现新的艾滋病毒感染病例。这一比率在新兴成年SMM(18-29岁)中最高， 据估计，79%至84%的艾滋病毒感染是由主要伴侣传播的。为回应这一事件 主要伴侣传播、夫妇艾滋病毒检测和咨询(CHTC)带来的担忧 被确认为既定的艾滋病毒预防战略。在CHTC期间，夫妇完成艾滋病毒检测和 共同制定预防计划。 CHTC目前的指导包括建议所有夫妇每6至12岁定期复查一次 月份。尽管这一重新测试建议具有标准性质，但没有研究从经验上评估 CHTC复测的效果。这一竞争性修订充分利用了NIH在母公司研究中的投资 (DA050508)，以获得CHTC年度复测的第一次结果数据。 DA050508目前正在招募240对居住在美国的男性夫妇，其中至少有一人的年龄： 17至29岁；艾滋病毒阴性；并报告最近(过去30天)吸毒(如大麻、可卡因/可卡因、 安非他明、摇头丸、伽马羟丁酸、氯胺酮或硝酸盐)，以及最近(过去3个月)的性行为 HIV传播的危险行为。作为参加DA050508的一部分，所有夫妇都要完成CHTC 一次又一次的会议。他们随后在3、6、9和12个月后完成随访评估。 基线。 这一修订的目的是评估与CHTC休息相关的好处。在他们12岁之后- 一个月的随访，这些参与者仍然保持着他们在他们 基准线将有机会继续采用本修订本中提议的组成部分。那些 同意将被随机分配，以完成CHTC的第二次会议，或 夫妻双方都会接受例行的个人艾滋病毒检测。血清不一致夫妇中的HIV阳性伴侣 随机进入对照状态将收到有关ART依从性和U=U的信息。 自然流失率和关系解离率，我们预计随机选择200对夫妇(原始夫妇的80% 示例)。后续评估将在重新测试后3个月和6个月(15个月和18个月后)进行 参与者最初的基线预约)。

项目成果

A full-factorial randomized controlled trial of adjunct couples HIV testing and counseling components addressing drug use and communication skills among sexual minority male couples.

• DOI: 10.1186/s12889-021-12208-3
• 发表时间: 2021-11-24
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Starks TJ;D Kyre K;B Cowles C;Castiblanco J;Washington C;N Parker J;M Kahle E;Stephenson R
• 通讯作者: Stephenson R