Tennessee Center for AIDS Research (TN-CFAR)

总体--项目摘要 几十年的研究已经产生了有可能预防所有新的艾滋病毒感染的知识和工具， 最终结束美国和全世界的艾滋病毒流行，改善生活在 艾滋病毒携带者。到目前为止，现实一直没有达到这些目标，部分原因是迫切的未得到满足的需求。田纳西州 艾滋病研究中心(CFAR)位于美国东南部，是世界上 新的艾滋病毒感染人数和艾滋病毒携带者人数。该CFAR成立于2015年，根据 西蒙·马拉尔教授的领导，作为一家研究密集型医疗机构之间的三方合作伙伴关系 (范德比尔特大学医学中心，VUMC)，历史上的黑人医学院(Meharry Medical College， MMC)，以及一个从事学术工作的州卫生局(田纳西州卫生局，TDH)。这 伙伴关系促进了合作，如果没有CFAR，这些合作是不可想象的。例如，一个 VUMC和MMC调查人员使用TDH监测数据进行的分析影响了全州的公共政策和 关于针头交换的法律，降低农村地区潜在破坏性艾滋病毒爆发的可能性 田纳西州。为了结束这种流行病，开展社区参与的研究变得越来越重要， 包括艾滋病毒携带者和高危人群。为此，CFAR新合作 纳什维尔关怀组织拥有第四个机构，是一个以社区为基础的复杂组织，已有25年的历史 独家关注艾滋病毒携带者和高危人群。通过这一四方伙伴关系，我们的愿景是 具有变革性、地方性和全球性的翻译影响。在这一愿景的指引下，我们的使命是协调 VUMC、MMC、TDH和CARE的机构和社区互补优势和资源 最有效地减轻艾滋病毒/艾滋病的负担，并在全国和全球推广这些好处。的工作 这份CFAR与国立卫生研究院在NIH/艾滋病研究方面的高度优先事项一致。为了完成我们的使命， CFAR将追求四个具体目标：1)支持利用高度 协作的当地环境，以在CFAR的四个机构之间建立有影响力的团队科学；2) 培养和支持初级调查员的职业发展，以增加初级调查员的数量和多样性 下一代艾滋病毒研究人员；3)专门为MMC调查人员提供艾滋病毒研究机会， 包括与整个CFAR的调查人员和资源的接触，并利用团队科学；以及4) 为了继续广泛重视贯穿CFAR的以艾滋病毒为重点的社区参与研究， 并将重点放在结束疫情上。

Overall – PROJECT SUMMARY Decades of research have generated knowledge and tools with the potential to prevent all new HIV infections, to ultimately end the HIV epidemic in the United States and worldwide, and to improve the lives of people living with HIV. To date, reality has fallen short of these goals, in part due to pressing unmet needs. The Tennessee Center for AIDS Research (CFAR) is located in the Southeastern United States, the region with the greatest number of new HIV infections, and of persons living with HIV. This CFAR was established in 2015, under the leadership of Prof. Simon Mallal, as a three-way partnership between a research-intensive medical institution (Vanderbilt University Medical Center, VUMC), a historically black medical college (Meharry Medical College, MMC), and an academically engaged state health department (Tennessee Department of Health, TDH). This partnership has fostered collaborations that would be unimaginable without CFAR. For example, results of an analysis by VUMC and MMC investigators using TDH surveillance data has affected statewide public policy and law regarding needle exchange, reducing the likelihood of a potentially devastating HIV outbreak in rural Tennessee. To end the epidemic, it is becoming increasingly important to pursue community-engaged research, to include both people living with HIV and those at high risk. Toward this end, this CFAR has newly partnered with a fourth institution, Nashville CARES, a sophisticated community-based organization with a 25-year exclusive focus on people living with HIV and those at high risk. Through this four-way partnership, our vision is to have transformative, local and global translational impact. Guided by this vision, our mission is to coordinate the complementary institutional and community strengths and resources of VUMC, MMC, TDH and CARES to most effectively reduce the burden of HIV/AIDS and generalize these benefits nationally and globally. Work of this CFAR aligns with National Institutes of Health high priorities for NIH/AIDS research. To fulfill our mission, this CFAR will pursue four specific aims: 1) To support multidisciplinary HIV research that leverages the highly collaborative local environment to build impactful team science among the four institutions of the CFAR; 2) To nurture and support career development of junior investigators, so as to grow the number and diversity of the next generation of HIV researchers; 3) To specifically enable HIV research opportunities for MMC investigators, to include engagement with investigators and resources across the CFAR, and leveraging team science; and 4) To continue to grow a broad emphasis on HIV-focused community-engaged research that pervades the CFAR, and with a focus on ending the epidemic.