Genomic Sciences Shared Resource

CORE 009-基因组科学共享资源 项目摘要/摘要 基因组科学共享资源(GSSR)的使命是带来新的和强大的基因组学 范德比尔特-英格拉姆癌症中心(VICC)研究社区的方法，包括我们的VICC成员 以及梅哈里医学院、田纳西州立大学和其他NCI中心的合作伙伴。世界银行的愿景 GSSR将迅速将最强大的现代和使能基因组学技术转化为实践和 让调查人员能够接触到这些信息。GSSR寻求最大限度地响应未得到满足的科学需求 并与VICC调查人员合作，开发和运营新的流程、平台、应用程序、 化验和干燥的实验室管道。为了支持调查人员的重要工作，GSSR提供了高水平的 科学礼宾支持。这包括关于适当技术、样品收集、处理和 提取、生物库和储存，以及质量评估。GSSR提供项目管理和研究 设计以保护样本和数据的完整性，数据管理和分析。GSSR寻求持续 在质量、成本、可伸缩性和周转时间方面的改进，以及 湿法和干法实验室阶段的分析/应用和样品类型。GSSR发现， 对于许多VICC研究人员来说，对基因组数据分析的需求正在迅速增加。因此，在下一次迭代中 对于CCSG，共享资源计划增加对用户的生物信息支持，包括处理 提供中间结果的数据(例如，RNAseq的计数表、DNAseq的变量调用等)以及提供 利用GSSR提供的持续高级专业知识进行分析和可视化的工具。重要的是， GSSR支持研究人员设计严格的实验方法，这些方法是透明和 可重现的。GSSR通过培训、非正式指导和提供的服务来实现这些目标 从核心开始。GSSR的工作人员特别适合促进良好的实验设计和验证 方法，为关键生物资源提供认证服务，并在定义和建立严格的 获取和分析基因组数据集的方法。

CORE 009 – GENOMIC SCIENCES SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The mission of the Genomic Sciences Shared Resource (GSSR) is to bring new and powerful genomics approaches to the Vanderbilt-Ingram Cancer Center (VICC) research community, inclusive of our VICC members and partners at Meharry Medical College, Tennessee State University, and other NCI centers. The vision of the GSSR is to rapidly translate the most powerful modern and enabling genomics technologies to practice and make these accessible to investigators. The GSSR seeks to maximize responsiveness to unmet scientific needs and partner with VICC investigators to develop and operationalize new processes, platforms, applications, assays and dry lab pipelines. To support investigators with their important work, the GSSR offers high level scientific concierge support. This includes advice on appropriate technology, sample collection, processing and extraction, biobanking and storage, and quality assessment. The GSSR offers project management and study design to protect sample and data integrity, data management and analysis. The GSSR seeks continuous improvement in quality, cost, scalability, and turn-around time, as well as an increase in the range of assays/applications and sample types across both wet and dry laboratory phases. GSSR has found that the need for genomic data analysis is increasing rapidly for many VICC investigators. Thus, over the next iteration of the CCSG, the shared resource plans to increase bioinformatic support for users, including the processing of data to deliver intermediate results (i.e. count table for RNAseq, variant calls for DNAseq, etc.) as well as provide tools for analysis and visualization with ongoing high-level expertise provided in the GSSR. Importantly, the GSSR supports researchers in the design of rigorous experimental approaches that are transparent and reproducible. The GSSR accomplishes these goals through training, informal mentorship and service provided by the core. The GSSR staff are particularly well suited to facilitating good experimental design and validated methods, providing authentication services for key biological resources and in defining and establishing rigorous methods for acquiring and analyzing genomic datasets.