Genomic Sciences Shared Resource

核心009 -基因科学共享资源 项目概要/摘要 基因组科学共享资源（GSSR）的使命是带来新的和强大的基因组学 与范德比尔特-英格拉姆癌症中心（VICC）研究社区的联系，包括我们的VICC成员 以及田纳西州立大学梅哈里医学院和其他NCI中心的合作伙伴。的愿景 GSSR将最强大的现代和使能基因组学技术快速转化为实践， 让调查人员能够接触到这些信息。GSSR旨在最大限度地满足未满足的科学需求 并与VICC调查人员合作，开发和实施新的流程、平台、应用程序， 分析和干燥实验室管道。为了支持调查人员的重要工作，GSSR提供高水平的 科学礼宾支持。这包括就适当的技术、样本收集、处理和 提取、生物库和储存以及质量评估。GSSR提供项目管理和研究 保护样品和数据完整性、数据管理和分析的设计。GSSR寻求持续的 质量、成本、可扩展性和周转时间方面的改进，以及 在湿和干实验室阶段的分析/应用和样品类型。GSSR发现， 对于许多VICC研究者来说，对基因组数据分析的需求正在迅速增加。因此，在下一次迭代中， 在CCSG中，共享资源计划增加对用户的生物信息支持，包括处理 提供中间结果的数据（即RNAseq的计数表、DNAseq的变体调用等）以及提供 分析和可视化工具，并在GSSR中提供持续的高级专业知识。重要的是 GSSR支持研究人员设计严格的实验方法，这些方法是透明的， 可复制的GSSR通过培训、非正式指导和提供服务来实现这些目标 的核心。GSSR的工作人员特别适合促进良好的实验设计和验证 方法，为关键生物资源提供认证服务， 用于获取和分析基因组数据集的方法。

CORE 009 – GENOMIC SCIENCES SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The mission of the Genomic Sciences Shared Resource (GSSR) is to bring new and powerful genomics approaches to the Vanderbilt-Ingram Cancer Center (VICC) research community, inclusive of our VICC members and partners at Meharry Medical College, Tennessee State University, and other NCI centers. The vision of the GSSR is to rapidly translate the most powerful modern and enabling genomics technologies to practice and make these accessible to investigators. The GSSR seeks to maximize responsiveness to unmet scientific needs and partner with VICC investigators to develop and operationalize new processes, platforms, applications, assays and dry lab pipelines. To support investigators with their important work, the GSSR offers high level scientific concierge support. This includes advice on appropriate technology, sample collection, processing and extraction, biobanking and storage, and quality assessment. The GSSR offers project management and study design to protect sample and data integrity, data management and analysis. The GSSR seeks continuous improvement in quality, cost, scalability, and turn-around time, as well as an increase in the range of assays/applications and sample types across both wet and dry laboratory phases. GSSR has found that the need for genomic data analysis is increasing rapidly for many VICC investigators. Thus, over the next iteration of the CCSG, the shared resource plans to increase bioinformatic support for users, including the processing of data to deliver intermediate results (i.e. count table for RNAseq, variant calls for DNAseq, etc.) as well as provide tools for analysis and visualization with ongoing high-level expertise provided in the GSSR. Importantly, the GSSR supports researchers in the design of rigorous experimental approaches that are transparent and reproducible. The GSSR accomplishes these goals through training, informal mentorship and service provided by the core. The GSSR staff are particularly well suited to facilitating good experimental design and validated methods, providing authentication services for key biological resources and in defining and establishing rigorous methods for acquiring and analyzing genomic datasets.