Patients Registry -Virtual Biorepository Core

摘要 我们BETRNet研究中心(RC)的主题是确定Barrett食道的遗传决定因素 (BE)和食管腺癌(EAC)，使遗传标记能够引导早期发现，风险分层， 预防和治疗。BETRNet患者登记处-虚拟生物库(PRVB)核心将与所有 我们参与机构的RC调查员继续并改进有效的方法和设计 成功地使我们能够跨机构共享人类生物标本和临床数据，从而有效地实现 我们的项目目标是我们现有的BETRNet，并将使我们的新项目取得成功。我们交流 定期与我们的RC调查人员合作，以确保他们能够获得高质量的、经过临床注释的 为他们的研究问题提供生物标本。此外，核心还提供安全的基础设施和监督 来自BETRNet RC的所有生物样本、临床、人口学和分子数据的管理，工作中 与我们的调查人员和BETRNet管理核心密切合作。核心将确保遵守数据 遵循BETRNet协调中心和NCI概述的指导方针进行共享 BETRNet计划办公室，以便向其他BETRNet RCS提供生物标本和数据以供研究。

SUMMARY The theme of our BETRNet Research Center (RC) is to identify genetic determinants of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) to enable genetic marker guided early detection, risk stratification, prevention and therapy. The BETRNet Patients Registry-Virtual Biorepository (PRVB) Core will interact with all RC investigators at our participating institutions to continue and improve the effective methods and designs that successfully enabled us to share human biospecimens and clinical data across institutions to efficiently achieve our project goals in our existing BETRNet and will enable success in our new projects. We communicate regularly with our RC investigators to make sure they have access to high quality, clinically annotated biospecimens for their research questions. In addition, the Core provides infrastructure and oversight for secure management of all biospecimen, clinical, demographic and molecular data from the BETRNet RC, working closely with our investigators and the BETRNet Administrative Core. The Core will ensure adherence to data sharing in adherence with the guidelines as outlined from the BETRNet Coordinating Center and the NCI BETRNet Program Office in order to provide biospecimens and data to other BETRNet RCs for research.