Patients Registry -Virtual Biorepository Core

患者登记处-虚拟生物样本库核心

• 批准号: 10153705
• 负责人: JOSEPH EDWARD WILLIS
• 金额: $ 29.05万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10153705
• 关键词: Adherence; Barrett Esophagus; Bioinformatics; Biometry; Biostatistics Core; Clinic; Clinical; Clinical Data; Comprehensive Cancer Center; Computational Biology; Core Facility; Data; Data Analyses; Database Management Systems; Databases; Department chair; Development; Early Diagnosis; Ensure; Esophageal Adenocarcinoma; Experimental Designs; Faculty; Formulation; Foundations; Genetic Determinism; Genetic Markers; Goals; Grant; Guidelines; Human; Human Resources; Informatics; Information Dissemination; Infrastructure; Institutes; Institution; Leadership; Manuscripts; Medical center; Methods; Molecular; North Carolina; Outcome; Pathology; Physician Executives; Pilot Projects; Prevention therapy; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Saints; Secure; Site; Universities; University Hospitals; Washington; Work; Writing; biobank; data management; data sharing; design; improved; medical schools; operation; patient registry; programs; risk stratification; skills; success; tissue resource; virtual

SUMMARY The theme of our BETRNet Research Center (RC) is to identify genetic determinants of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) to enable genetic marker guided early detection, risk stratification, prevention and therapy. The BETRNet Patients Registry-Virtual Biorepository (PRVB) Core will interact with all RC investigators at our participating institutions to continue and improve the effective methods and designs that successfully enabled us to share human biospecimens and clinical data across institutions to efficiently achieve our project goals in our existing BETRNet and will enable success in our new projects. We communicate regularly with our RC investigators to make sure they have access to high quality, clinically annotated biospecimens for their research questions. In addition, the Core provides infrastructure and oversight for secure management of all biospecimen, clinical, demographic and molecular data from the BETRNet RC, working closely with our investigators and the BETRNet Administrative Core. The Core will ensure adherence to data sharing in adherence with the guidelines as outlined from the BETRNet Coordinating Center and the NCI BETRNet Program Office in order to provide biospecimens and data to other BETRNet RCs for research.

总结 我们BETRNet研究中心（RC）的主题是确定巴雷特食管的遗传决定因素 (BE)和食管腺癌（EAC），以实现遗传标记指导的早期检测，风险分层， 预防和治疗。BETRNet患者登记-虚拟生物储存库（PRVB）核心将与所有 我们参与机构的RC调查员继续并改进有效的方法和设计， 成功地使我们能够跨机构共享人类生物标本和临床数据， 我们的项目目标在我们现有的BETRNet，并将使我们的新项目的成功。我们沟通 定期与我们的RC研究人员，以确保他们能够获得高质量的，临床注释 生物标本来回答他们的研究问题此外，核心还提供基础设施和监督， 管理来自BETRNet RC的所有生物标本、临床、人口统计学和分子数据， 与我们的调查人员和BETRNet行政核心密切合作。核心将确保遵守数据 按照BETRNet协调中心和NCI概述的指导方针进行共享 BETRNet计划办公室，以便向其他BETRNet RC提供生物标本和数据用于研究。