Bioreagents & Resources Core

生物试剂

基本信息

  • 批准号:
    10713943
  • 负责人:
  • 金额:
    $ 18.6万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-20 至 2028-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY The Biospecimen and Reagents Core [BRC] provides high quality annotated specimens and expert pathology consultation to enhance the P01 projects. The BR&C CWRU and Duke components have long track records of supporting multi-investigator basic, translational and clinical research relating to multiple aspects of the Barrett's Esophagus [BE] and BE- neoplasia. The BRC is co-lead by two nationally recognized gastrointestinal pathologists with expertise in esophageal pathology who have well established track records in tissue-based translational research. The BRC co-leaders have worked together for many years and have longstanding collaborations with the P01 teams. The BRC components have differencing and complementary resources. Both the CWRU and the Duke components have large bioarchives which have been used to support multiple large scale NIH funded projects for over 20+ years. The BR&C has tissue and blood biospecimens from over 6,200 patients suitable for this P01. The BR&C leverages the Case CCC Shared Resources, the UH Pathology Translational Research Core and the Duke BioRepository & Precision Pathology Center shared resource to maximize efficiencies, utilize their expertise and advanced technologies. For Project 1 the BRC was integral to the discovery of germline abnormalities of VSIG10L as a predisposing factor in some patients with Familial Barrett's Esophagus. The BRC worked with Prj 1 to define the knock in and knock out mouse models which form the basis of this project and identified a multilayer epithelium complex in Prj 1 murine models – recognized as a robust marker of BE changes and linked to BE in humans. For Project 2 the BRC and collaborators developed the novel approach of using pigs as a model for esophageal injury – including the study of esophageal submucosal glands [ESMGs] as a potential site of origin of BE. Inspired by this effort, Prj 2 and the BRC identified and provided sections of ESMGs during screening of multiple esophagectomies and then worked with Prj 2 to immunoprofile the ESMGs. The molecular mechanisms identified formed the basis for the project. For Project 3 the BRC supplied high quality tissue samples and immunohistochemistry expertise in the investigation of EPHB2 signaling in esophageal carcinogenesis used to define potential pathways of development of BE – results of which formed the basis for the project. The BRC, with Core C, will continue to provide support to the P01 investigators and will enhance their projects by supplying quality controlled esophagus tissues, human and animal pathology expertise and facilitate state of the art tissue diagnostics including immunohistochemistry, ISH, tissue microdissection, spatial transcriptomics and single cell sequencing.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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JOSEPH EDWARD WILLIS其他文献

JOSEPH EDWARD WILLIS的其他文献

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{{ truncateString('JOSEPH EDWARD WILLIS', 18)}}的其他基金

Pathology Core
病理学核心
  • 批准号:
    10267197
  • 财政年份:
    2020
  • 资助金额:
    $ 18.6万
  • 项目类别:
Pathology Core
病理学核心
  • 批准号:
    10478906
  • 财政年份:
    2020
  • 资助金额:
    $ 18.6万
  • 项目类别:
Pathology Core
病理学核心
  • 批准号:
    10084626
  • 财政年份:
    2020
  • 资助金额:
    $ 18.6万
  • 项目类别:
Biospecimen/Pathology Core
生物样本/病理学核心
  • 批准号:
    10005928
  • 财政年份:
    2018
  • 资助金额:
    $ 18.6万
  • 项目类别:
Validation of Methylated Vimentin as a Diagnostic Test for Barrett's Esophagus
甲基化波形蛋白作为巴雷特食管诊断测试的验证
  • 批准号:
    9923576
  • 财政年份:
    2016
  • 资助金额:
    $ 18.6万
  • 项目类别:
Core 1: Biospecimen Core
核心 1:生物样本核心
  • 批准号:
    10227749
  • 财政年份:
    2011
  • 资助金额:
    $ 18.6万
  • 项目类别:
Project 2: Translational Significance of a Mutational Signature of African American Colon Cancers
项目 2:非裔美国人结肠癌突变特征的转化意义
  • 批准号:
    10227753
  • 财政年份:
    2011
  • 资助金额:
    $ 18.6万
  • 项目类别:
Identification of Significant Race Associated Colon Cancer Drive Gene Mutations
显着种族相关结肠癌驱动基因突变的鉴定
  • 批准号:
    8097073
  • 财政年份:
    2011
  • 资助金额:
    $ 18.6万
  • 项目类别:
Patients Registry -Virtual Biorepository Core
患者登记处-虚拟生物样本库核心
  • 批准号:
    10153705
  • 财政年份:
    2011
  • 资助金额:
    $ 18.6万
  • 项目类别:
Identification of Significant Race Associated Colon Cancer Drive Gene Mutations
显着种族相关结肠癌驱动基因突变的鉴定
  • 批准号:
    8330850
  • 财政年份:
    2011
  • 资助金额:
    $ 18.6万
  • 项目类别:

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