Core 1: Biospecimen Core
核心 1:生物样本核心
基本信息
- 批准号:10227749
- 负责人:
- 金额:$ 23.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-14 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:African AmericanArchivesBarrett EsophagusBiological AssayBiological MarkersBloodBlood specimenCenter for Translational Science ActivitiesClinicalClinical MedicineClinical TrialsCollaborationsCollectionColon CarcinomaColonic NeoplasmsComprehensive Cancer CenterConfidentiality of Patient InformationConsultationsCore FacilityCustomDNADataData SetDevelopmentDissectionEnsureEsophageal mucous membraneEsophagusExperimental DesignsExperimental PathologyFacultyFormalinFormulationFreezingFresh TissueFrozen SectionsGenerationsGenesGlutamineGoalsGrantHistologyHumanHuman ResourcesImmunohistochemistryIn Situ HybridizationIndividualInformation DisseminationInstitutionInstitutional Review BoardsLaboratoriesLinkMalignant neoplasm of esophagusMalignant neoplasm of gastrointestinal tractManuscriptsMedical centerMetabolismMicrodissectionModificationMolecularMolecular AnalysisMorphologyMusMutateNeoplasm MetastasisNeoplasmsOutcomeOxidoreductasePIK3CA geneParaffinParaffin EmbeddingParticipantPathologicPathologyPatientsPharmacologyPilot ProjectsPlayProceduresProcessProstaglandinsProtocols documentationQuality ControlRNAResearchResearch PersonnelResearch Project GrantsResourcesRoleSamplingScheduleServicesSpecimenTechniquesTechnologyTest ResultTestingTissue EmbeddingTissue MicroarrayTissue ProcurementsTissue SampleTissuesTranslational ResearchTumor Suppressor GenesUniversity HospitalsVimentinWorkWritingbasebiological specimen archivesblood fractionationcareercentral databaseclinical databasecolon carcinogenesiscost effectivedesignexperiencefollow-upgastrointestinalhuman tissueinsightinterestlaser capture microdissectionmeetingsmemberprogramsprospectiveresearch studyskillssuccesstechnology developmenttissue archivetissue processingtranslational cancer researchtranslational study
项目摘要
PROJECT SUMMARY/ABSTRACT
The Biospecimen Core will continue to provide high quality annotated specimens and expert pathology
consultation to enhance the projects of Case GI SPORE investigators. This process will continue the
longstanding, successful, collaborations between the members of the Core and the individual project
investigators. During the course of these collaborations the Core has developed an extensive biospecimen
archive derived from over 13,000 patients. Previously, the Core has supplied high quality annotated specimens
leading to the discovery of 15-Prostaglandin Dehydrogenase as an important tumor suppressor gene in colon
carcinogenesis – the basis of Project 1; the African American colon cancer 15 gene-panel – the basis of Project
2; methylated vimentin as a biomarker of Barrett's Esophagus – the basis of Project 3; and the discovery of
unique glutamine metabolism in PIK3CA mutated colon cancers – the basis of Project 4. The Core also provided
significant support to the SPORE's Career Enhancement and Pilot Projects Programs. The Core has an
extensive archive of colon neoplasms from over 4,800 patients including 2,292 primary colon cancers of known
pathologic stage and databased clinical follow-up as well as a substantial number of cancer metastases. Frozen
material from 1053 of these cases is also banked with matched normal controls. The Core also has 350
esophageal cancers and Barrett's esophagus paraffin specimens as well as 134 frozen esophageal specimens.
Many of these samples have undergone extensive molecular analysis – enabling sophisticated translational
studies. The Core works with the Case Comprehensive Cancer Center to make available to the SPORE a wide
variety of techniques and technologies in a cost effective manner. The Core will organize all prospective GI
biospecimen procurements and distribution to SPORE investigators as well as provide access to its existing
tissue archive resource. The Core will support the projects of this application by identification of tissues of interest
to investigators both from the Core archive and from prospective accrual. The Core will provide histopathological
quality control for tissue sections, along with project specific morphology case reviews and will oversee and
provide longitudinal follow-up of clinical outcomes linked to these tissues. The Core will also provide tissue
microarray sections for tissue targets of interest, expertise in immunohistochemistry and in situ hybridization
assessment and samples appropriate for specific studies. The primary objective is to provide a resource that
contributes significantly to the translational goals and endpoints of the individual projects and to facilitate
cooperation between other GI SPOREs.
项目总结/摘要
生物标本核心将继续提供高质量的注释标本和专家病理学
咨询,以加强案例GI孢子调查员的项目。这一进程将继续下去,
核心成员和单个项目之间长期、成功的合作
investigators.在这些合作的过程中,核心已经开发了一个广泛的生物标本,
来自13,000多名患者的档案。以前,核心提供高质量的注释标本
导致发现15-前列腺素脱氢酶作为结肠中重要的肿瘤抑制基因
致癌作用-项目1的基础;非裔美国人结肠癌15基因组-项目的基础
2;甲基化波形蛋白作为巴雷特食管的生物标志物-项目3的基础;以及
PIK 3CA突变结肠癌中独特的谷氨酰胺代谢-项目4的基础。核心还提供了
对SPORE的职业提升和试点项目计划的重大支持。芯部具有
来自4,800多名患者的结肠肿瘤的广泛档案,包括2,292例已知的原发性结肠癌
病理分期和基于数据库的临床随访以及大量的癌症转移。冷冻
来自这些病例中的1053例的材料也与匹配的正常对照一起储存。核心也有350个
食管癌和Barrett食管石蜡标本以及134例冷冻食管标本。
这些样品中的许多已经过广泛的分子分析,
问题研究核心与病例综合癌症中心合作,为SPORE提供广泛的
以具有成本效益的方式使用各种技术和工艺。核心将组织所有潜在的GI
生物标本采购和分发给SPORE调查人员,并提供对其现有标本的访问权限
组织档案资源。核心将通过识别感兴趣的组织来支持本申请的项目
从核心档案和预期应计中向研究者提供。核心将提供组织病理学检查
组织切片的质量控制,沿着项目特定形态学病例审查,并将监督和
提供与这些组织相关的临床结局的纵向随访。核心还将提供组织
感兴趣的组织靶点的微阵列切片,免疫组织化学和原位杂交的专业知识
评估和样品适合特定的研究。主要目标是提供一种资源,
对各个项目的转化目标和终点做出重大贡献,并促进
与其他GI SPORE合作。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOSEPH EDWARD WILLIS其他文献
JOSEPH EDWARD WILLIS的其他文献
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{{ truncateString('JOSEPH EDWARD WILLIS', 18)}}的其他基金
Validation of Methylated Vimentin as a Diagnostic Test for Barrett's Esophagus
甲基化波形蛋白作为巴雷特食管诊断测试的验证
- 批准号:
9923576 - 财政年份:2016
- 资助金额:
$ 23.25万 - 项目类别:
Project 2: Translational Significance of a Mutational Signature of African American Colon Cancers
项目 2:非裔美国人结肠癌突变特征的转化意义
- 批准号:
10227753 - 财政年份:2011
- 资助金额:
$ 23.25万 - 项目类别:
Identification of Significant Race Associated Colon Cancer Drive Gene Mutations
显着种族相关结肠癌驱动基因突变的鉴定
- 批准号:
8097073 - 财政年份:2011
- 资助金额:
$ 23.25万 - 项目类别:
Patients Registry -Virtual Biorepository Core
患者登记处-虚拟生物样本库核心
- 批准号:
10153705 - 财政年份:2011
- 资助金额:
$ 23.25万 - 项目类别:
Identification of Significant Race Associated Colon Cancer Drive Gene Mutations
显着种族相关结肠癌驱动基因突变的鉴定
- 批准号:
8330850 - 财政年份:2011
- 资助金额:
$ 23.25万 - 项目类别:
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