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Pathology Core

病理学核心

基本信息

批准号：
10267197
负责人：
JOSEPH EDWARD WILLIS
金额：
$ 5.29万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-21 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10267197
关键词：
Acquired Immunodeficiency Syndrome Affect Africa African Algorithms American Area Artificial Intelligence Awareness Biological Specimen database Biopsy Biopsy Specimen Cancer Etiology Classification Clinical Clinical Pathology Clinical Research Computer software Consensus Consultations Core Facility Custom DNA Data Databases Diagnosis Diagnostic ERBB2 gene Educational process of instructing Enrollment Epidemiology Epidermal Growth Factor Receptor Ethnic Origin Europe Expenditure Faculty Funding Gene Mutation Goals HIV HIV-1 Histologic Hospitals Image Immunohistochemistry Individual Infection Informatics Infrastructure Institutes Joints KRAS2 gene Karnofsky Performance Status Laboratories Lesion Link Lung Lung Adenocarcinoma Malignant Neoplasms Malignant neoplasm of lung Medical Research Medical center Mission Modernization Molecular Mutation Analysis Oncology Online Systems Outcome Pathologic Pathology Patients Persons Physicians Population Pulmonary Mass RNA Reporting Research Resources Risk Factors Sampling Scanning Serum Services Ships Site Slide Somatic Mutation Specimen Standardization Surgical Pathology System Tanzania Techniques Technology Technology Transfer Telepathology Tissue Sample Tissue imaging Tissues Translational Research Tribes Tumor stage Uganda United States National Institutes of Health Universities University Hospitals Visit Work cancer risk case control demographics design diagnosis quality diagnostic accuracy digital digital imaging experience flexibility health care delivery improved infrastructure development material transfer agreement mortality next generation sequencing participant enrollment personalized diagnostics programs prospective radiological imaging repository routine care success user-friendly

项目摘要

ABSTRACT – Path Core The Pathology Core will provide services to this proposal essential to the success of the projects. The Core will leverage existing technologies and infrastructure in Uganda and Tanzania as well as CWRU to provide reliable diagnoses of prospective project enrollees. The Pathology Core facilities include state of the art slide scanners which have been installed at the two African Pathology coordinating centers. The scanners are part of a large multi-institutional continent-wide program organized by the American Pathology of Clinical Pathology to improve surgical pathology diagnostic standards in Africa through a program of targeted infrastructure development. This program has enabled both teaching for faculty and residents in pathology diagnostics as well as facilitating pathology consultations across the globe. The slide scanning system and software are robust and user friendly. The program has been extremely successful and has been extensively implemented – linking multiple pathology departments in Africa to departments throughout the US and Europe. The design of the Core will facilitate rapid turnaround of pathology diagnoses through consensus. The two African center Pathology Leaders have extensive experience in the presentation of a host of non-cancerous lesions of the lung. This experience compliments that of Dr Willis, the Pathology Core Leader at CWRU, with his extensive experience in diagnostic oncology. The CWRU Pathology Core Center also has extensive experience in digital slide imaging management and translational research having extensive engagement with the CWRU Center for Computational Imaging & Personalized Diagnostics. Central to the mission of the core is standardization of diagnoses through teaching and cross center engagement. This will include cross visits by Drs Willis and Lukande. The core will also engage in important technology transfer of the technique of immunohistochemistry to both main sites in Africa. Immunohistochemistry is fundamental to modern diagnostic pathology and a pillar of diagnostic accuracy especially in oncology. Techniques to be introduced are designed to be used in low / middle resource centers and are flexible so that incremental additions to immunohistochemical panels can be performed with only minimal expenditures. The primary objective of the Core is to provide a resource that contributes significantly to the translational goals and endpoints of the individual projects, to facilitate cooperation between the three sites and to identify areas of potential further expansion of oncology–related translational research.

摘要-路径核心