Nuclear Control of Cell Growth and Differentiation (NC)

细胞生长和分化的核调控 摘要 细胞生长和分化的核控制（NC）计划是一个基础科学计划，提供 创新的方法，导致对癌症发展机制基础的有效理解。 领导层、成员和活动联合收割机结合起来，实现亨斯迈癌症的特定方面。 研究所（HCI）的使命声明-“从一开始就了解癌症”。具体做法就是 实验的重点是基本核过程和途径的基本机制， 癌细胞并有助于肿瘤发生。NC成员使用创新的发现科学和临床前 用于剖析细胞生长和分化的基本方面的模型，所述细胞生长和分化发生在和/或 撞击原子核。在这些广泛的目标，研究在数控程序追求三个具体目标：1） 破译基因失调在癌症中的作用; 2）确定代谢失调之间的关系 以及癌症中的基因网络;以及3）揭示癌症中DNA损伤，复制和修复的改变机制。 癌这三个具体目标中的每一个都涉及对正常核过程的研究， as their其dysregulation失调in cancer癌症.需要对这两种状态有深入和基本的了解， 最有效的诊断，最适合的治疗，以及最清晰和最有效的指导方针 与预防有关-符合人道主义行动的使命。 NC计划有33名成员，他们在犹他州的12个大学部门中担任学术职务， 学校/学院。计划成员资金充足，资金轨迹非常积极， 越来越关注癌症。同行评审资金的直接成本总计1110万美元，其中390万美元（35%） 来自国家癌症研究所。项目成员发表了329篇同行评审论文; 12% 其中27%是方案内努力的结果，27%是方案间合作的结果。二十- 7%的出版物发表在影响因子大于10的期刊上。 作为一个以癌症为重点的基础科学项目，NC计划对癌症产生了重大的积极影响。 中心通过创新和研究卓越的基因调控，癌症代谢和基因组 稳定--以及加强这些领域的人力资本投资受训者的教育和培训。NC提供 发现科学，可以转化为临床和人口，特别注意了解 HCI集水区高发病率癌症的基本机制，包括黑色素瘤，肺， 乳腺癌和儿童癌症。NC计划成员继续在以癌症为重点的 发现研究，并与所有四个HCI研究项目的同事合作，以产生转化影响。

NUCLEAR CONTROL OF CELL GROWTH AND DIFFERENTIATION PROGRAM ABSTRACT The Nuclear Control of Cell Growth and Differentiation (NC) Program is a basic science program that provides innovative approaches that lead to impactful understanding of the mechanistic basis of cancer development. The leadership, membership, and activities combine to achieve a particular aspect of the Huntsman Cancer Institute (HCI) mission statement—“to understand cancer from its beginnings.” This is accomplished through experimentation focused on mechanisms underlying basic nuclear processes and pathways that go awry in cancer cells and contribute to oncogenesis. NC members use innovative discovery science and preclinical models for the purpose of dissecting fundamental aspects of cell growth and differentiation that occur in and/or impact the nucleus. Within these broad goals, research in the NC Program pursues three Specific Aims: 1) to decipher the roles of gene dysregulation in cancer; 2) to define relationships between metabolic dysregulation and gene networks in cancer; and 3) to reveal altered mechanisms of DNA damage, replication, and repair in cancer. Each of these three Specific Aims involves the investigation of both normal nuclear processes, as well as their dysregulation in cancer. A deep and fundamental understanding of both states is needed to develop the most effective diagnostics, the best tailored therapies, and the clearest and most effective guidelines related to prevention—in alignment with the mission of HCI. The NC Program has 33 members with academic appointments in 12 University of Utah departments in three schools/colleges. Program members are well funded, with a strongly positive funding trajectory that is increasingly cancer-focused. Peer-reviewed funding totals $11.1M in direct costs, of which $3.9M (35%) derives from the National Cancer Institute. Program members published 329 peer-reviewed papers; 12% represented intra-programmatic efforts and 27% resulted from inter-programmatic collaborations. Twenty- seven percent of publications were in journals with an impact factor greater than 10. As a cancer-focused basic science program, the NC Program has a major positive impact on the Cancer Center through innovation and research excellence in gene regulation, cancer metabolism, and genome stability—as well as enhancing education and training of HCI trainees in these areas. Thus, NC provides discovery science that can be translated to the clinic and population, with special attention to understanding basic mechanisms underlying cancers of high incidence in HCI’s catchment area, including melanoma, lung, breast, and childhood cancers. NC Program members continue to play leading roles in cancer-focused discovery research and partner with colleagues in all four HCI Research Programs for translational impact.