MEDIC - MicroED Imaging Center - Community Engagement

MEDIC - MicroED 成像中心 - 社区参与

• 批准号: 10155532
• 负责人: Tamir Gonen
• 金额: $ 9.48万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10155532
• 关键词: Algorithms; Automobile Driving; Awareness; Biological; Books; Collaborations; Communities; Community Outreach; Computer software; Country; Cryoelectron Microscopy; Crystallization; Crystallography; Data; Data Analyses; Data Collection; Development; Drug Design; Educational workshop; Equipment; Future; Goals; Guidelines; Image; Information Dissemination; Institution; Internet; Knowledge; Laboratories; Laboratory Research; Learning; Link; Methodology; Methods; Micro Electron Diffraction; Negative Staining; Online Systems; Parents; Participant; Preparation; Protocols documentation; Publications; Recommendation; Research; Research Activity; Research Design; Research Methodology; Research Personnel; Resources; Roentgen Rays; Sampling; Scientist; Services; Site; Site Visit; Structure; Supervision; System; Techniques; Technology; Time; Titan; Training; Travel; United States National Institutes of Health; Visit; Work; base; community center; community engagement; computerized data processing; data sharing; drug discovery; experience; experimental study; instrument; instrumentation; member; operation; outreach; programs; protocol development; symposium; technology research and development

Community engagement SUMMARY The primary goals of the community engagement of the proposed MEDIC BTRR are (1) to disseminate and to provide access to MicroED technology, and (2) to facilitate new and exciting research that perhaps is intractable by other methods. This will be mainly accomplished by providing: (1) access to MicroED instrumentation and facilitating interactions with experienced scientists to all who wish to conduct MicroED experiments as part of their own research programs, and (2) outreach to relevant scientific communities in efforts to disseminate recent MicroED advances in a direct and hands-on manner. The Gonen laboratory has worked diligently at community outreach to spread MicroED technology by holding workshops, training new users and collaborated with many groups from research laboratories across the country. To help facilitate continued expansion of MicroED and further collaborations, the MEDIC center will be open to those researchers who have demonstrated a need and desire to conduct MicroED experiments. Collaborators will be able to visit the MicroED imaging center from around the country to engage in MicroED data collection and learn first-hand how to perform the data collection and analysis. We foresee that the greatest collaborator base for MicroED will be within the existing crystallography, cryoEM communities and chemists. Crystallographers have limited experience in the technique, but a wealth of knowledge in crystallization, sample preparation, data collection, analysis using X-ray software while cryoEM, users have access to equipment and cryoEM capabilities for data collection. Chemists and those that are working on drug design and discovery are enthusiastic about MicroED for its potential in facilitating rapid structure determination from femtogram amounts of material that are intractable by other methods. Therefore, we will focus our outreach on these communities through the variety of means described below.

社区参与 总结 拟议的MEDIC BTRR社区参与的主要目标是（1）传播和 提供MicroED技术，（2）促进新的和令人兴奋的研究，也许是棘手的 通过其他方法。这将主要通过以下方式实现：（1）使用MicroED仪器， 促进与经验丰富的科学家的互动，以所有希望进行MicroED实验的人， 他们自己的研究计划，以及（2）与相关科学界的联系，努力传播最近的 MicroED以直接和动手的方式进步。戈恩实验室一直在社区努力工作， 通过举办研讨会、培训新用户和与许多国家合作， 来自全国各地的研究实验室。为了帮助促进MicroED的持续扩展， 进一步的合作，MEDIC中心将开放给那些已经证明有需要的研究人员， 希望进行MicroED实验。合作者将能够访问MicroED成像中心， 在全国各地从事MicroED数据收集和学习第一手如何执行数据收集 和分析我们预计，MicroED最大的合作者基础将在现有的 晶体学，cryoEM社区和化学家。晶体学家在这项技术上的经验有限， 但在结晶、样品制备、数据收集、使用X射线软件进行分析方面有丰富的知识 而cryoEM，用户可以使用设备和cryoEM功能进行数据收集。化学家和那些 致力于药物设计和发现的科学家对MicroED充满热情，因为它有潜力促进快速 从毫微微克量的材料中确定结构，这是其他方法难以解决的。因此，我们认为， 我们将通过下述各种方式，集中对这些社区进行外联。