MEDIC - MicroED Imaging Center - Admin Core

MEDIC - MicroED 成像中心 - 管理核心

• 批准号: 10641810
• 负责人: Tamir Gonen
• 金额: $ 14.7万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641810
• 关键词: Advisory Committees; Automobile Driving; Biological; Budgets; Chemistry; Communication; Computing Methodologies; Cryoelectron Microscopy; Crystallography; Educational workshop; Eligibility Determination; Ensure; Fostering; Funding; Goals; Grant; Human Resources; Instagram; Joints; Leadership; Maintenance; Medical center; Methodology; Micro Electron Diffraction; Mind; Mission; Molecular Structure; Natural Products; Online Systems; Persons; Post-Translational Protein Processing; Preparation; Principal Investigator; Procedures; Progress Reports; Protocols documentation; Qualifying; Recommendation; Reporting; Research; Research Activity; Research Personnel; Research Support; Resolution; Resource Sharing; Resources; Role; Schedule; Secure; Site; Structure; Suggestion; Synchrotrons; Techniques; Technology; Teleconferences; Training; Twitter; United States National Institutes of Health; Update; X-Ray Crystallography; community engagement; electron diffraction; experience; image reconstruction; imaging facilities; improved; meetings; member; nano; news; particle; programs; research and development; social media; structural biology; technology development; technology research and development; web site

ADMINISTRATION AND MANAGEMENT SUMMARY The Administrative Core (AC) will provide an organizational framework for the proposed multi-investigator project, the MEDIC – MicroED Imaging Center at UCLA. The AC will be led by the two PIs, Drs. Tamir Gonen and Pawel Penczek. The joint directorship of the MEDIC center will ensure efficient functioning of the Resource uninterrupted by other responsibilities of the PIs. The activities of this Core will include synchronization of the research and technology development of all groups, the maintenance of communications with and between Driving Biological Projects, the resolution of budgetary issues, organization of monthly meetings for an Internal Advisory Committee, a yearly meeting of an External Advisory Meeting, and up to two training and dissemination workshops per year. It will also be responsible for the preparation of the yearly Progress Report and will maintain and update the Resource Sharing facility. The center will benefit from Dr. Gonen having extensive experience in managing cryoEM resources and multi-user facility projects. Dr. Gonen established and directed several cryoEM facilities around the USA in the last 15 years, including the most prolific cryoEM user facility at the Janelia Research Campus of HHMI which was the first synchrotron-like facility for cryoEM in the world. Dr. Penczek has 20 years of successful NIH-supported research including participation in multi-PI program project and joined PI grants. In addition, for 12 years Dr. Penczek served as a Director of the UTH Structural Biology Imaging Center, a multi-user facility supporting structural biology research at UT Medical Center, including NMR, X-ray crystallography, and cryo-EM and operating under an independent budget. Under his leadership the facility grew, culminating in the successful acquisition of a UT-funded Krios TEM in 2017. Since 2017 Dr. Penczek serves as a co-director of the UT Center. Together, Drs. Gonen and Penczek will formulate an Internal Advisory Committee comprised of elite members of the Technology Research and Development projects (TRDs) and select key personnel. This committee will establish and ensure optimal operating procedures for MEDIC, access procedures and criteria for determining eligible projects. It will be also responsible for determination and the format of technology dissemination workshops and, if necessary, for reallocation of funds between TRD projects. Of utmost importance is the establishment of the External Advisory Committee. The role of this Committee will be to advise on the overall scientific direction of the project, advise on dissemination efforts and community engagement, help to maintain its focus and to stay devoted and faithful to the original mission of MEDIC. The Administrative Core will organize a yearly one-day meeting of the External Advisory Committee and its members will be expected to prepare a report that will be shared with all PIs and key personnel of the Project and with the NIH.

管理和管理 概括 行政核心（AC）将为拟议的多项式投票程序提供组织框架 Project，UCLA的Medic - 微型成像中心。 AC将由两个PIS领导。塔米尔·戈宁（Tamir Gonen） 和Pawel Penczek。医疗中心的联合董事职位将确保资源有效运作 不受PI的其他职责不间断。该核心的活动将包括同步 所有群体的研究和技术发展，与 驱动生物学项目，预算问题的解决，组织每月会议的内部会议 咨询委员会，外部咨询会议的年度会议，以及最多两次培训和传播 每年研讨会。它还将负责准备年度进度报告，并将维护 并更新资源共享设施。该中心将受益于Gonen博士在拥有丰富经验的Gonen博士 管理冷冻资源和多用户设施项目。 Gonen博士建立并导演了几个冷冻 在过去的15年中，美国各地的设施，包括Janelia的最多产的冷冻用户设施 HHMI的研究校园是世界上第一个类似于Cryoem的同步基因的设施。 Penczek博士有 20年成功的NIH支持研究，包括参与Multi-Pi计划项目并加入PI 赠款。此外，Penczek博士担任UTH结构生物学成像中心的主任， UT医疗中心的结构生物学研究的多用户设施，包括NMR，X射线 晶体学和冷冻EM并在独立预算下运行。在他的领导下，设施的发展， 最终在2017年成功地收购了UT资助的Krios Tem。自2017年以来，Penczek博士担任 UT中心的联合导演。在一起，博士。 Gonen和Penczek将成立一个内部咨询委员会 累积技术研发项目（TRD）的精英成员并选择关键 人员。该委员会将建立并确保医生的最佳操作程序，访问 确定合格项目的程序和标准。它也将负责确定和 技术传播研讨会的格式，并在必要时进行TRD项目之间的资金重新分配。 最重要的是成立外部咨询委员会。该委员会的角色将 就该项目的整体科学方向提供建议，就传播工作和社区提供建议 参与，帮助保持重点，并保持部署并忠于Medic的原始任务。 行政核心将组织外部咨询委员会的年度一日会议及其成员 期望将准备一份报告，该报告将与该项目的所有PI和关键人员共享，并与 NIH。