MEDIC - MicroED Imaging Center - Community Engagement

MEDIC - MicroED 成像中心 - 社区参与

• 批准号: 10641836
• 负责人: Tamir Gonen
• 金额: $ 9.47万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641836
• 关键词: Algorithms; Automobile Driving; Awareness; Biological; Books; Collaborations; Communities; Community Outreach; Computer software; Country; Cryoelectron Microscopy; Crystallization; Crystallography; Data; Data Analyses; Data Collection; Dedications; Drug Design; Educational workshop; Equipment; Future; Goals; Guidelines; Information Dissemination; Institution; Internet; Knowledge; Laboratories; Laboratory Research; Learning; Link; Methodology; Methods; Micro Electron Diffraction; Negative Staining; Online Systems; Parents; Participant; Preparation; Protocols documentation; Publications; Recommendation; Research; Research Activity; Research Design; Research Methodology; Research Personnel; Resources; Roentgen Rays; Sampling; Scientist; Services; Site; Site Visit; Structure; System; Techniques; Technology; Titan; Training; Travel; United States National Institutes of Health; Visit; Work; base; community engagement; computerized data processing; data sharing; drug discovery; experience; experimental study; imaging facilities; instrument; instrumentation; member; operation; outreach; practice setting; programs; protocol development; research and development; symposium; technology development

Community engagement SUMMARY The primary goals of the community engagement of the proposed MEDIC BTRR are (1) to disseminate and to provide access to MicroED technology, and (2) to facilitate new and exciting research that perhaps is intractable by other methods. This will be mainly accomplished by providing: (1) access to MicroED instrumentation and facilitating interactions with experienced scientists to all who wish to conduct MicroED experiments as part of their own research programs, and (2) outreach to relevant scientific communities in efforts to disseminate recent MicroED advances in a direct and hands-on manner. The Gonen laboratory has worked diligently at community outreach to spread MicroED technology by holding workshops, training new users and collaborated with many groups from research laboratories across the country. To help facilitate continued expansion of MicroED and further collaborations, the MEDIC center will be open to those researchers who have demonstrated a need and desire to conduct MicroED experiments. Collaborators will be able to visit the MicroED imaging center from around the country to engage in MicroED data collection and learn first-hand how to perform the data collection and analysis. We foresee that the greatest collaborator base for MicroED will be within the existing crystallography, cryoEM communities and chemists. Crystallographers have limited experience in the technique, but a wealth of knowledge in crystallization, sample preparation, data collection, analysis using X-ray software while cryoEM, users have access to equipment and cryoEM capabilities for data collection. Chemists and those that are working on drug design and discovery are enthusiastic about MicroED for its potential in facilitating rapid structure determination from femtogram amounts of material that are intractable by other methods. Therefore, we will focus our outreach on these communities through the variety of means described below.

社区参与 摘要 拟议中的BTRR的社区参与的主要目标是：(1)传播和 提供获得MicroED技术的途径，以及(2)促进新的、令人兴奋的研究，这些研究可能是棘手的 用其他方法。这将主要通过以下方式实现：(1)使用MicroED仪器和 促进与有经验的科学家的互动，让所有希望进行MicroED实验的人成为 他们自己的研究计划，以及(2)与相关科学界的接触，努力传播最近的 MicroED以直接和亲身实践的方式取得进展。戈南实验室在社区中勤奋工作 通过举办研讨会、培训新用户并与许多人合作来推广MicroED技术 来自全国各地研究实验室的小组。帮助促进MicroED的持续扩展和 进一步的合作，医疗中心将向那些已经证明有需求和 希望进行MicroED实验。合作者将能够从以下位置访问MicroED成像中心 在全国各地从事MicroED数据收集并第一手学习如何进行数据收集 和分析。我们预计MicroED的最大合作者基础将在现有的 结晶学、低温EM社区和化学家。结晶学家在这项技术上的经验有限， 但在结晶、样品制备、数据收集、使用X射线软件进行分析方面拥有丰富的知识 在CryoEM的同时，用户可以访问设备和用于数据收集的CryoEM能力。化学家和那些 致力于药物设计和发现的人对MicroED充满热情，因为它在促进快速 用其他方法难以处理的材料的飞秒图量来确定结构。因此， 我们将通过下文所述的各种手段，将我们的宣传重点放在这些社区上。