Development of Self-Detoxifying Filter Media for Active Decontamination

开发用于主动净化的自解毒过滤介质

• 批准号: 10155952
• 负责人: DAVID Mark BATTAGLIA
• 金额: $ 25.08万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-11 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10155952
• 关键词: 2019-nCoV; Address; Aerosols; Air Movements; Antiviral Agents; Area; Binding; COVID-19; Chemical Warfare Agents; Chemistry; Coronavirus; Decontamination; Development; Disadvantaged; Drops; Ensure; Enterobacteria phage MS2; Environment; Evaluation; Exposure to; Face; Fiber; Filtration; Health Personnel; Hydrogen Peroxide; Immune system; Ligands; Longevity; Measurable; Mechanical Stress; Methods; Modification; Patients; Phase; Procedures; Process; Property; Research; Research Personnel; Risk; Safety; Scientist; Silicon Dioxide; Solid; Surface; System; Technology; Texas; Virus; Work; aerosolized; air filtration; air monitoring; antimicrobial; base; combat; commercialization; design; experience; fiberglass; healing; high efficiency particulate air filter; improved; nanomaterials; novel; pathogen; pressure; remediation; technology development; thermal stress; toxic industrial chemical

PROJECT SUMMARY Systems that utilize various filtration media are one of the first lines of defense against aerosolized pathogens. They are critical in providing a safe/clean environment for patients, medical personnel, or researchers. Without these filters, those with compromised immune systems, or those working with highly contagious pathogens, can face deadly situations. Even with these filters in place, certain pathogens have the potential to pass through or even survive within the filter. Due to the small size of many viruses, the coronavirus SARS-CoV-2 is ~100nm, no filter is 100% effective at capturing all aerosolized pathogens. Furthermore, re- aerosolization of certain captured pathogens can also take place during normal use, when the filter is assessed to determine its remaining lifespan, or when the filter needs to be replaced entirely. Herein lies Lynntech’s focus in this area. Lynntech plans to address these shortcomings in filtration media through the addition of novel solid and stable hydroperoxy ligands that will immediately, and continually, terminate captured aerosolized pathogens such as the coronavirus SARS-CoV-2 virus that causes COVID-19. Self-detoxifying filters would allow for the complete termination of any pathogen that might normally remain active on untreated filters as well as eliminate the potential for re-aerosolization of active pathogens. This would allow for not only increased protection of those relying on the filters, but also mitigate the risks of those who would normally assess or change the filters. Many of the efforts towards the modification of filtration media for active decontamination have been partially successful, however, they have all come with their own drawbacks that Lynntech will attempt overcome with its own method of filter modification. During this Phase 1 project, Lynntech will demonstrate proof-of-concept by pursuing the following specific aims: (1) functionalization of commercial fiberglass-based filter media with hydroperoxy ligands, (2) assessment of antimicrobial properties of hydroperoxy-treated filters, and (3) evaluation of the “irreversibility” and safety of bound hydroperoxy ligands. Successful completion of these specific aims should demonstrate ample feasibility of using Lynntech’s filter modification technology and allow for Lynntech to plan more comprehensive technology development and commercialization avenues. Overall, this technology provides a great opportunity to drastically improve the safety of those who are working or healing in potentially harmful environments. This technology could even be extended to further decontamination avenues such as chemical warfare agents, or toxic industrial chemicals.

项目摘要 利用各种过滤介质的系统是防止雾化的第一道防线之一。 病原体它们对于为患者、医务人员或其他人员提供安全/清洁的环境至关重要。 研究人员如果没有这些过滤器，那些免疫系统受损的人，或者那些工作在高水平的人， 传染性病原体，可能面临致命的情况。即使有了这些过滤器，某些病原体仍然具有 有可能通过过滤器，甚至在过滤器中存活。由于许多病毒的体积很小， SARS-CoV-2是~ 100 nm，没有过滤器是100%有效地捕捉所有雾化的病原体。此外，再-- 当对过滤器进行评估时，某些捕获的病原体的气溶胶化也可以在正常使用期间发生 以确定其剩余寿命，或何时需要完全更换过滤器。这就是Lynntech的重点 在这一地区。Lynntech计划通过添加新型固体颗粒来解决过滤介质中的这些缺点。 和稳定的过氧氢配体，其将立即并持续地终止捕获的气溶胶化病原体 例如导致COVID-19的冠状病毒SARS-CoV-2。自我解毒过滤器将允许 完全终止任何可能在未处理的过滤器上正常保持活性的病原体， 活性病原体重新雾化的可能性。这不仅可以增加对这些人的保护， 这不仅减少了对过滤器的依赖，而且还减轻了那些通常会评估或更换过滤器的人的风险。许多 为主动净化而改进过滤介质的努力已经部分地 然而，成功的，他们都有自己的缺点，Lynntech将试图克服其 自己的过滤器修改方法。在第一阶段项目中，Lynntech将通过以下方式展示概念验证： 追求以下具体目标：（1）商业玻璃纤维基过滤介质的功能化， 过氧化氢配体，（2）过氧化氢处理过的过滤器的抗微生物性能评估，和（3）评价 的“不可逆性”和安全性的结合过氧氢配体。圆满完成这些具体目标 应证明使用Lynntech的过滤器修改技术的充分可行性，并允许Lynntech 规划更全面的技术开发和商业化途径。总的来说，这项技术 提供了一个很好的机会，大大提高那些谁是工作或愈合的潜在安全 有害环境。这项技术甚至可以扩展到进一步的净化途径，如 化学战剂或有毒工业化学品。