Development of Self-Detoxifying Filter Media for Active Decontamination

项目总结 利用各种过滤介质的系统是防止雾化的第一道防线之一。 病原体。它们对于为患者、医务人员或 研究人员。没有这些过滤器，那些免疫系统受损的人，或者那些高度 传染性病原体，可能会面临致命的情况。即使有了这些过滤器，某些病原体也有 有可能通过过滤器，甚至在过滤器内存活。由于许多病毒的体积很小，冠状病毒 SARS-CoV-2的大小约为100 nm，任何滤器都不能100%捕获所有气雾化病原体。此外，重新- 在评估过滤器时，某些捕获的病原体在正常使用期间也可能发生气雾化。 以确定其剩余寿命，或何时需要完全更换过滤器。这就是Lynntech的重点所在 在这片区域。Lynntech计划通过添加新型固体来解决过滤介质中的这些缺点 和稳定的过氧化氢配体，可以立即并持续地消灭捕获的气雾化病原体 比如引起新冠肺炎的冠状病毒SARS-CoV-2。自排毒过滤器将允许 完全终止任何通常可能在未经处理的过滤器上保持活跃的病原体，以及消除 活性病原体重新气雾化的可能性。这不仅可以加强对那些 依赖过滤器，但也减轻了那些通常会评估或更换过滤器的人的风险。许多 对用于主动去污的过滤介质进行改进的努力部分地 然而，它们都取得了成功，都有自己的缺点，Lynntech将试图通过其 自己的过滤器修改方法。在此第一阶段项目中，Lynntech将通过以下方式演示概念验证 追求以下具体目标：(1)商用玻璃纤维滤料的功能化 过氧氢配体，(2)过氧氢处理过滤器的抗微生物性能的评估，以及(3)评估 结合的过氧化氢配体的“不可逆性”和安全性。圆满完成这些具体目标 应展示使用Lynntech过滤器修改技术的充分可行性，并允许Lynntech 规划更全面的技术开发和商业化途径。总的来说，这项技术 提供了一个极大的机会来极大地提高那些在潜在的环境中工作或康复的人的安全 有害环境。这项技术甚至可以扩展到进一步的净化途径，如 化学战剂或有毒工业化学品。

PROJECT SUMMARY Systems that utilize various filtration media are one of the first lines of defense against aerosolized pathogens. They are critical in providing a safe/clean environment for patients, medical personnel, or researchers. Without these filters, those with compromised immune systems, or those working with highly contagious pathogens, can face deadly situations. Even with these filters in place, certain pathogens have the potential to pass through or even survive within the filter. Due to the small size of many viruses, the coronavirus SARS-CoV-2 is ~100nm, no filter is 100% effective at capturing all aerosolized pathogens. Furthermore, re- aerosolization of certain captured pathogens can also take place during normal use, when the filter is assessed to determine its remaining lifespan, or when the filter needs to be replaced entirely. Herein lies Lynntech’s focus in this area. Lynntech plans to address these shortcomings in filtration media through the addition of novel solid and stable hydroperoxy ligands that will immediately, and continually, terminate captured aerosolized pathogens such as the coronavirus SARS-CoV-2 virus that causes COVID-19. Self-detoxifying filters would allow for the complete termination of any pathogen that might normally remain active on untreated filters as well as eliminate the potential for re-aerosolization of active pathogens. This would allow for not only increased protection of those relying on the filters, but also mitigate the risks of those who would normally assess or change the filters. Many of the efforts towards the modification of filtration media for active decontamination have been partially successful, however, they have all come with their own drawbacks that Lynntech will attempt overcome with its own method of filter modification. During this Phase 1 project, Lynntech will demonstrate proof-of-concept by pursuing the following specific aims: (1) functionalization of commercial fiberglass-based filter media with hydroperoxy ligands, (2) assessment of antimicrobial properties of hydroperoxy-treated filters, and (3) evaluation of the “irreversibility” and safety of bound hydroperoxy ligands. Successful completion of these specific aims should demonstrate ample feasibility of using Lynntech’s filter modification technology and allow for Lynntech to plan more comprehensive technology development and commercialization avenues. Overall, this technology provides a great opportunity to drastically improve the safety of those who are working or healing in potentially harmful environments. This technology could even be extended to further decontamination avenues such as chemical warfare agents, or toxic industrial chemicals.