Kits for Converting Nanocrystals to Standard Bio-Medical Reagents

将纳米晶体转化为标准生物医学试剂的试剂盒

基本信息

项目摘要

DESCRIPTION (provided by applicant): This SBIR Phase II program intends to develop the second generation of semiconductor nanocrystals (q-dots) based bio-medical labels to eliminate the usage of toxic cadmium element, to be physically permeable, and to not possess any self-quenching of the photoluminescence. This will be realized by a new invention, bright nanocrystal emitters based on doped non- cadmium semiconductor nanocrystals (d-dots), and the dendron-nanocrystal technology developed in the Phase I. NN-Labs has the exclusive patent rights for both key technologies. To accomplish this Phase II program, a balanced team in technology and business is assembled, with the original inventors, the scientists at NN-Labs and Professor Xiaogang Peng's group at the University of Arkansas (subcontractor), as the R&D team, Professor Shawn Chen at Stanford School of Medicine as the Medical Partner, Sigma-Aldrich as the Marketing Partner, and ImmunoVision (a subsidiary at Arkansas of IVAX diagnostics) as the Strategic Partner. D-dot labels possess nearly all advantages of q-dot labels in comparison to traditional fluorescent labels. Q-dot labels are currently developed for diagnostics and other types of bio- medical detection worldwide. However, the workhorse, cadmium selenide and related q-dots, is problematic. For example, European Union will start to ban any new products containing intentionally added in this summer. This major challenge will be nicely solved by d-dots technology, which relies on tunable emissions of doping centers in zinc based semiconductor nanocrystals. This unique fluorescence mechanism makes d-dots have zero self-quenching and thermally stable, which is an intrinsic problem for both organic dyes and q-dot labels. The unique emission mechanism and the dendron-nanocrystal technology reduce the total size of d- dot labels to that of a typical protein (a few nanometers), which is substantially smaller than the current standard products of q-dots labels, several tens of nanometers in size. Although q-dot technologies are currently pursued by companies worldwide, the unique patent position of NN-Labs on d-dot dendron-nanocrystals will likely place United States in front of other competitors in this promising industry field. Such opportunities are needed for the State of Arkansas to meet its long term mission, to develop this traditionally rural state to a knowledge- based and environmentally benign industry harbor.
描述(申请人提供):该SBIR第二阶段计划旨在开发基于半导体纳米晶体(Q-点)的第二代生物医学标签,以消除有毒镉元素的使用,具有物理渗透性,并且不具有任何自猝灭的光致发光。这将通过一项新发明实现,即基于掺杂非镉半导体纳米晶(d-dots)的明亮纳米晶发射器,以及一期开发的树枝状纳米晶技术。NN-Labs拥有这两项关键技术的独家专利权。为了完成这一第二阶段计划,我们组建了一个技术和商业平衡的团队,最初的发明者、NN-Labs的科学家和阿肯色大学的彭晓刚教授团队(分包商)作为研发团队,斯坦福大学医学院的Shawn Chen教授作为医疗合作伙伴,Sigma-Aldrich作为营销合作伙伴,免疫视觉公司(IVAX诊断公司在阿肯色州的子公司)作为战略合作伙伴。与传统的荧光标记相比,D-点标记几乎具有Q-点标记的所有优点。Q点标签目前在全球范围内被开发用于诊断和其他类型的生物医学检测。然而,主力硒镉和相关的Q点是有问题的。例如,欧盟将于今年夏天开始禁止任何含有故意添加的新产品。这一重大挑战将通过d-dots技术很好地解决,该技术依赖于锌基半导体纳米晶体中掺杂中心的可调发射。这种独特的荧光机制使得d-点具有零自猝灭和热稳定性,这是有机染料和Q-点标记的固有问题。独特的发射机制和树枝状纳米晶技术将d-点标记的总尺寸缩小到典型蛋白质的大小(几纳米),大大小于目前Q-点标记的标准产品,几十纳米大小。尽管目前世界各地的公司都在追求Q点技术,但NN-Labs在d点树枝状纳米晶体方面的独特专利地位可能会使美国在这一前景广阔的行业领域领先于其他竞争对手。阿肯色州需要这样的机会来实现其长期使命,将这个传统上位于农村的州发展成为一个以知识为基础、对环境友好的工业港。

项目成果

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DAVID Mark BATTAGLIA其他文献

DAVID Mark BATTAGLIA的其他文献

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{{ truncateString('DAVID Mark BATTAGLIA', 18)}}的其他基金

Development of Self-Detoxifying Filter Media for Active Decontamination
开发用于主动净化的自解毒过滤介质
  • 批准号:
    10155952
  • 财政年份:
    2020
  • 资助金额:
    $ 40.2万
  • 项目类别:
Enhanced Non fouling Membranes for Water Purification and Recycling
用于水净化和回收的增强型防污膜
  • 批准号:
    8779813
  • 财政年份:
    2014
  • 资助金额:
    $ 40.2万
  • 项目类别:
Enhanced Non Fouling Membranes for Water Purification and Recycling
用于水净化和回收的增强型防污膜
  • 批准号:
    9355646
  • 财政年份:
    2014
  • 资助金额:
    $ 40.2万
  • 项目类别:
High Yield and Inexpensive Production of Quality Gold Nanocrystals for Bio-Labels
高产且廉价地生产用于生物标签的优质金纳米晶体
  • 批准号:
    7052658
  • 财政年份:
    2006
  • 资助金额:
    $ 40.2万
  • 项目类别:
MATERNAL AGING AND MEIOTIC REGULATION IN OOCYTES
母体衰老和卵母细胞减数分裂调节
  • 批准号:
    2673768
  • 财政年份:
    1994
  • 资助金额:
    $ 40.2万
  • 项目类别:
MATERNAL AGING AND MEIOTIC REGULATION IN OOCYTES
母体衰老和卵母细胞减数分裂调节
  • 批准号:
    2204738
  • 财政年份:
    1994
  • 资助金额:
    $ 40.2万
  • 项目类别:
MATERNAL AGING AND MEIOTIC REGULATION IN OOCYTES
母体衰老和卵母细胞减数分裂调节
  • 批准号:
    2204737
  • 财政年份:
    1994
  • 资助金额:
    $ 40.2万
  • 项目类别:
MATERNAL AGING AND MEIOTIC REGULATION IN OOCYTES
母体衰老和卵母细胞减数分裂调节
  • 批准号:
    2204736
  • 财政年份:
    1994
  • 资助金额:
    $ 40.2万
  • 项目类别:
MATERNAL AGING AND MEIOTIC REPRODUCTION IN OOCYTES
母体衰老和卵母细胞减数分裂繁殖
  • 批准号:
    2889117
  • 财政年份:
    1994
  • 资助金额:
    $ 40.2万
  • 项目类别:
MATERNAL AGING AND MEIOTIC REPRODUCTION IN OOCYTES
母体衰老和卵母细胞减数分裂繁殖
  • 批准号:
    2389521
  • 财政年份:
    1994
  • 资助金额:
    $ 40.2万
  • 项目类别:

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Center: IUCRC Phase III University of Arkansas: Center for Membrane Applications, Science and Technology (MAST)
中心:IUCRC 第三阶段 阿肯色大学:膜应用、科学与技术中心 (MAST)
  • 批准号:
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    2024
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    $ 40.2万
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  • 批准号:
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Arkansas Department of Health's Rapid Response Team Building Project
阿肯色州卫生部的快速反应团队建设项目
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Building Capacity for Critical Need STEM and Special Education Teachers in Southeast Arkansas
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    2243016
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    2023
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会议:阿肯色州春季系列讲座
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REU Site: Summer Research in Physics at the University of Arkansas
REU 网站:阿肯色大学物理学暑期研究
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