Communicating Cancer Risk to Co-users of Alcohol and Little Cigar and Cigarillos

摘要 本申请是对特别利益通知(NOSI)的回应，该通知被确认为 不是-CA-20-039。在美国，超过三分之一的癌症死亡可归因于吸烟和 喝酒。这两种行为协同影响患多种癌症的风险。几乎没有研究表明 已经就如何传达酒精和烟草共同使用的致癌风险进行了研究，尽管事实是 这两种物质的共同使用率很高。公共卫生研究人员已经成功地使用了一些策略，例如 媒体活动、销售点广告和警告标签--宣传癌症风险 与烟草有关。相比之下，关于告知信息的交际策略的研究较少 关于酒精的致癌风险。据我们所知，没有沟通策略被用来 就同时饮酒和吸烟的致癌风险进行交流。建议的长期目标是 行政补充是确定传达关于癌症风险的信息是否 饮酒和吸烟会增加风险认知、感知的信息有效性、知识和 目前共用烟草的人戒烟意向和减少饮酒意向 还有酒。为了实现这一目标，我们提出了一个具体目标，该目标将补充和增加重要的 对我们的父母研究的价值(1R01CA240732-01)，该研究侧重于传播癌症和其他健康 小雪茄和雪茄(LCC)的风险。具体地说，对于这个行政副刊，我们的目标是开发 并在实验上测试关于共同使用酒精和烟草的癌症风险的通信消息(例如， “酒精和烟草都会增加患口腔癌的风险”)在1000名成年人的不同样本中 目前饮酒和吸烟的LCC。我们将对年轻人和非裔美国人进行过度抽样，因为 在年轻人中，酒精和烟草的共同使用尤其成问题，而非裔美国成年人 与白人成年人相比，更有可能使用LCC。参与者将从美国各地招募参加一项 一系列的在线实验。我们的工作假设是，最有力的沟通信息 酒精和烟草的致癌风险(例如，提到特定癌症的消息，描述该癌症的 后果，并包括促进戒烟自我效能的文本)将增加风险感知 信息有效性、知识和戒烟意向以及减少饮酒意向 LCC和酒精的共同使用者。从我们的行政副刊和家长研究中得出的信息可以 用于媒体活动、销售点广告以及各州、地方和其他机构的警告标签 各国提高对同时饮酒和吸烟致癌风险的认识。本副刊还可能 提供数据支持一项随机对照试验，以确定共同使用癌症信息是否会导致 行为上的改变。

ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-20-039. Over a third of cancer deaths in the United States are attributable to using tobacco and drinking alcohol. These two behaviors synergistically impact the risk of multiple cancers. Little research has been conducted on how to communicate the cancer risks of alcohol and tobacco co-use, despite the fact that co-use of both substances is high. Public health researchers have successfully used strategies—such as media campaigns, point-of-sale advertisements, and warning labels—to communicate about cancer risks linked to tobacco. Comparatively, less research exists about communication strategies to inform messages about the cancer risks of alcohol. No communication strategies, to our knowledge, have been used to communicate about the cancer risks of co-using alcohol and tobacco. The long-term goal of the proposed administrative supplement is to determine whether messages that communicate about the cancer risks of cousing alcohol and tobacco increase risk perceptions, perceived message effectiveness, knowledge, and tobacco quit intentions and decrease alcohol use intentions among individuals who currently co-use tobacco and alcohol. To accomplish this goal, we propose one specific aim that will complement and add significant value to our Parent Study (1R01CA240732-01), which is focused on communicating cancer and other health risks of little cigars and cigarillos (LCCs). Specifically, for this administrative supplement, we aim to develop and experimentally test communication messages about the cancer risks of co-using alcohol and tobacco (e.g., “alcohol and tobacco both increase your risk of oral cancer”) among a diverse sample of 1,000 adults who currently drink alcohol and smoke LCCs. We will oversample young adults and African Americans because the co-use of alcohol and tobacco is especially problematic among young adults, and African American adults are more likely to use LCCs than white adults. Participants will be recruited from across the US to participate in a series of online experiments. Our working hypothesis is that the most robust communication messages about the cancer risks of alcohol and tobacco (e.g., messages that mention a specific cancer, describe the cancer’s consequences, and include text to promote quitting self-efficacy) will increase risk perceptions, perceived message effectiveness, knowledge, and tobacco quit intentions and decrease alcohol use intentions among co-users of LCCs and alcohol. Messages developed from our administrative supplement and Parent Study can be used in media campaigns, point-of-sale advertising, and warning labels by states, localities, and other countries to increase awareness of cancer risks of co-using alcohol and tobacco. This supplement may also provide data to support a randomized controlled trial to determine if cancer messaging on co-use leads to behavioral changes.