A novel research infrastructure enabling life-course studies of healthy aging

项目总结： 在增长和发展的关键时期，对固定的未来产能进行“规划”。 影响长期健康。早期生命因素可能通过血管系统在成功衰老中发挥作用，因为 血管结构和功能的亚临床变化发生在衰老过程的早期，导致亚临床 认知和身体功能的临床变化。了解这些早期生活因素在 保持身体和认知功能对于确定理想的途径至关重要 成功老化。该提案中包含的3项研究(Bogalusa心脏研究[BHS，路易斯安那州]，NHLBI 生长与健康研究[NGHS，俄亥俄州]，普林斯顿脂质研究[PLRS，俄亥俄州])招募黑人和 持续跟踪40多年的白人儿童和青少年。每个队列都有 多年来的多个分研究和这些宝贵的、未得到充分利用的资源(数据和生物标本) 需要基础设施发展，以有效地利用NIH投资，并通过 生命历程数据的跨学科使用，预期收集了40多年的数据。我们的长期合作 目的是了解童年、青春期和青壮年对衰老过程的影响。整体而言 这项建议的目标是发展和加强一个新的研究基础设施，以促进 在早期生命领域的老龄化科学和有助于“成功”衰老的儿童保护因素。 具体地说，在R21阶段，我们将对生物存储库进行编目和整合，创建清晰和详细的 为每个队列编制文件，并建立3个队列的综合统一数据文件。这些 活动将独一无二地定位于队列，以提供对童年之间路径的生命过程评估 健康和生活方式因素以及衰老过程中靶器官损害的中间标志物。在R33公路上 阶段，我们将通过电话采访来演示远程测量方法的可行性 评估慢性疾病、行动能力、身体和认知功能、社会支持和生活质量，以及 使用唾液和大便的邮寄样本采集试剂盒以及移动设备评估身体风险因素数据 评估心率、心电、血压、脉搏血容量和血氧饱和度。未来老龄化研究的流行病学效度 将通过远程联系和移动评估老龄化相关结果的测试方法来增强 技术，使已远离童年的队列成员能够在未来参与 家乡。拟议的调查小组是多学科的，拥有儿科、心脏病学、 内科、神经学、流行病学和生物统计学。最终，此应用程序建议增强 独特的科学资源，将促进有效的生命历程方法，以确定通往成功的理想道路 利用NIH几十年的投资。

Project Summary: There are critical periods in growth and development where “programming” of fixed future capacity takes place impacting long-term health. Early life factors may play a role in successful aging via the vascular system since subclinical changes in vascular structure and function occur early in the aging process, contributing to sub- clinical changes in cognition and physical functioning. Understanding the role of these early life factors in the maintenance of physical and cognitive function is of critical importance for identifying the ideal path to successful aging. The 3 studies included in this proposal (Bogalusa Heart Study [BHS, Louisiana], NHLBI Growth and Health Study [NGHS, Ohio], Princeton Lipid Research Study [PLRS, Ohio]) enrolled black and white children and adolescents who have continued follow for up for more than 40 years. Each cohort has had multiple sub-studies over the years and these valuable, under-utilized resources (data and bio-specimens) require infrastructure development to efficiently leverage NIH investment and advance aging sciences through the interdisciplinary use of life-course data, prospectively collected over more than 4 decades. Our long-term goal is to understand the childhood, adolescent, and young adult influences on the aging process. The overall objective of this proposal is to develop and enhance a novel research infrastructure that will advance the science of aging in the area of early life and childhood protective factors that contribute to “successful” aging. Specifically, in the R21 phase, we will catalog and consolidate biorepositories, create clear and detailed documentation for each cohort and build comprehensive harmonized data files across the 3 cohorts. These activities will uniquely position the cohorts to provide life-course assessments of pathways between childhood health and lifestyle factors and intermediate markers of target organ damage in the aging process. In the R33 phase, we will demonstrate the feasibility of remote measurement methods by conducting telephone interviews to assess chronic conditions, mobility, physical and cognitive function, social support and quality of life, and assess physical risk factor data using mailed sample collection kits for saliva and stool as well as mobile assessments of HR, ECG, BP, PWV, and oxygen saturation. Epidemiologic validity for future aging studies will be enhanced by testing methods for assessing aging-related outcomes with remote contact and mobile technologies, enabling the future participation of cohort members who have moved away from their childhood hometowns. The investigative team proposed is multidisciplinary, with expertise in pediatrics, cardiology, internal medicine, neurology, epidemiology and biostatistics. Ultimately, this application proposes to enhance a unique scientific resource that will facilitate valid life-course approaches to define the ideal path to successful aging, leveraging decades of NIH investment.