Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart Study

项目摘要 中年的心血管（CV）风险因素被认为会影响晚年的认知状态。结果 临床试验表明，改变老年人的心血管风险因素可能是降低晚期心血管疾病风险的一种有希望的途径。 生命认知能力下降在此，我们在母授权2 RF 1AG 041200的范围内提出了一项补充，标题为 “终生心血管风险暴露和阿尔茨海默病相关的大脑健康：博加卢萨心脏研究”，旨在确定 这些疾病以种族和性别特异性的方式共享的可改变的风险因素，并确定关键时间 预防和延迟阿尔茨海默病和相关痴呆综合征（ADRD）发作的窗口， 差距。父母补助金将收集600名儿童的认知表现和亚临床神经成像的信息。 200名参加博加卢萨心脏研究（BHS）的中年黑人和白色男性和女性。的 候选人德安达杜兰博士，将利用母基金收集的数据，通过应用先进的分析方法， 这将区分影响大脑功能的CV风险因素的生命过程（童年到中年）轨迹。这项工作 将扩展传统的神经心理学（NP）方法，通过识别 亚临床NP表型可能更容易进展为ADRD。轻度认知障碍（MCI）是一种 关键阶段通常导致进展为ADRD;然而，准确识别这种前驱症状具有挑战性， 不一致可能导致ADRD中观察到的神经病理学异质性。充分和及时 使用数据表征更可能进展为痴呆和/或类似MCI的神经认知表型， 驱动方法可能是解决疾病负担和优化患者临床试验资格的潜在途径 减少风险的干预措施。数据驱动的方法似乎在识别和分类个人方面更精确 基于与不太模糊的神经病理学相关的不同NP表型。为此，我们建议评估 黑人和白色受试者中CV风险因素的生命过程暴露与中年NP表型之间的关系 来自路易斯安那州博加卢萨的一个半农村、社区为基础的中年成年人群体。这项工作具有重要意义 临床和公共卫生影响。认知表型的早期表征可以更好地识别倾向于 进展为认知障碍综合征和可能对临床干预更敏感的高危人群， 并从有针对性的预防策略中获益最多。此外，拟议的补充将提供候选人，博士。 德安达杜兰，与必要的保护时间，以获得所需的技能，成为和独立资助 研究员

Project Summary Cardiovascular (CV) risk factors in midlife are recognized to influence later-life cognitive status. Results from clinical trials have suggested that modifying CV risk factors in older adults may be a promising avenue to lower risk of late life cognitive decline. Herein, we propose a supplement, within the scope of the parent grant 2RF1AG041200, entitled ‘Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart Study’ which aims to identify modifiable risk factors shared by these conditions in a race- and sex-specific fashion, and determine the critical time windows to prevent and delay the onset of Alzheimer’s Disease and related dementia syndromes (ADRD) and minimize disparities. The parent grant will collect information on cognitive performance among 600 and neuroimaging of sub-clinical brain injury 200 black and white men and women who participate in the Bogalusa Heart Study (BHS) in middle age. The candidate Dr. De Anda-Duran, will leverage the data collected by the parent grant, by applying advanced analytical methods that will distinguish life-course (childhood to midlife) trajectories of CV risk factors that impact brain function. This work will expand on traditional neuropsychological (NP) approaches to characterize midlife cognitive performance by identifying subclinical NP phenotypes that may be more susceptible to progression to ADRD. Mild cognitive impairment (MCI) is a pivotal stage often leading to progression to ADRD; however, accurate identification of this prodrome is challenging, and inconsistencies might contribute to the neuropathological heterogeneity seen in ADRD. Adequate and timely characterization of neurocognitive phenotypes that more likely progress to dementia, and/or resemble MCI, using data- driven approaches can be a potential pathway to address disease burden and optimize patient eligibility for clinical trials and risk reduction interventions. Data-driven approaches appear to be more precise in identifying and classifying individuals based on distinct NP phenotypes linked with less ambiguous neuropathology. To this end, we propose to evaluate the relationship between life-course exposure to CV risk factors and midlife NP phenotypes among black and white participants from a semi-rural, community-based cohort of middle-aged adults located in Bogalusa, Louisiana. This work has important clinical and public health implications. Early characterization of cognitive phenotypes may better identify groups prone to progress to cognitive impairment syndromes and high-risk groups who may be more responsive to clinical interventions, and benefit most from targeted prevention strategies. Moreover, the proposed supplement will provide the candidate, Dr. De Anda-Duran, with the necessary period of protected time to gain the skills required to become and independently funded researcher.