Administrative Supplement Request to Lifespan Cardiovascular Risk Exposures and Alzheimer-related Brain Health

心血管(CV)危险因素的突然变化，特别是饮食质量、体力活动成就和 睡眠卫生，通常伴随着中老年人的手术等急性医疗事件 成年人。这些突然的变化与较差的长期认知和大脑结果有关。科维德- 19大流行导致了不同版本的突然变化：大量健康的成年人变得受限于 在很长一段时间里，家庭改变了他们购物食物、餐馆就餐、运动和 由于家庭禁闭令及其挥之不去的后遗症，运动参与和睡眠。《The Covid19》 大流行正在推动一种新的、不同形式的简历和生活方式因素的突然变化，健康 其影响尚不清楚。我们在这份补充材料中的直接目标是严格评估 与新冠肺炎大流行相关的心血管风险因素突然变化，有一个长期目标是评估 在大规模流行病学研究中，这种心血管变化与认知和大脑变化之间的关系 一群人。本附录将使用经过验证的技术来客观评估新冠肺炎相关的饮食变化， 参与调查的中年黑人和白人男性和女性的身体活动和睡眠 博加卢萨心脏研究(BHS)参与者，并已同意对心血管风险因素进行纵向评估， 大脑结果和认知结果，通过他们在父母资助中的登记(RO1 AG041200)。我们会 为250名BHS参与者提供手腕佩戴的加速计，能够评估睡眠质量和身体状况 活动实现(Actigraph WGT3X+)以及远程食物摄影方法(通过 智能手机应用程序(SmartIntake®应用程序)。体力活动和睡眠质量将客观地 在7天内测量，在4天内摄取食物。此数据与以前的 通过对队列中早期清扫的饮食、体力活动和睡眠质量的评估，我们将定位于 校准和分析这三个心血管风险因素因新冠肺炎大流行而发生的变化。此数据将 让我们评估这种突然的个人简历风险变化对认知和大脑结果以及种族的影响 这种联系中的差异，以澄清与大流行相关的生活方式对公共健康的长期影响 改变。本附录收集的数据有效地利用了家长拨款(重点关注简历风险和 大脑结果)在具有相当大的少数族裔代表性(35%的非裔美国人)的人群中，并且可能 确定一种新的生活方式干预措施的目标，以便在未来的大流行中迅速部署和扩大规模 保持健康的方法。利用NIH在Bogalusa心脏研究中的长期投资是 研究大流行相关心血管危险因素突变对认知的影响的最佳方法 和大脑健康。

Sudden changes in cardiovascular (CV) risk factors, especially diet quality, physical activity attainment, and sleep hygiene, commonly accompany acute medical events such as surgeries among middle aged and older adults. These sudden changes are associated with poorer long-term cognitive and brain outcomes. The Covid- 19 pandemic caused a different version of sudden change: large numbers of healthy adults became confined to the home for extended periods of time, changed their patterns of food shopping, restaurant eating, sports and exercise engagement, and sleep due to home confinement orders and their lingering after-effects. The Covid19 pandemic is promoting a new and different form of sudden change in CV and lifestyle factors, the health impacts of which are not clear. Our immediate goal in this supplement is to rigorously assess the extent of sudden CV risk factor changes associated with the Covid-19 pandemic, with a long-term goal of assessing relationships between such cardiovascular changes and cognitive and brain changes in a large epidemiological cohort. This supplement will use validated technologies to objectively assess Covid-19-related changes to diet, physical activity, and sleep among black and white men and women in mid-life who have participated in the Bogalusa Heart Study (BHS) participants, and already consented to longitudinal assessment of CV risk factors, brain outcomes, and cognitive outcomes via their enrollment in the parent grant (RO1 AG041200). We will provide 250 BHS participants with wrist-worn accelerometers capable of assessing sleep quality and physical activity attainment (ActiGraph WGT3X+) as well as Remote Food Photography Methods© implemented via a smartphone application (the SmartIntake® app). Physical activity and sleep quality will be objectively measured over a 7-day period, and food intake over a 4-day period. This data, together with previous assessments of diet, physical activity, and sleep quality from earlier sweeps through the cohort, will position us to calibrate and analyze changes in these three CV risk factors due to the Covid-19 pandemic. This data will position us to assess effects of such sudden CV risk changes on cognitive and brain outcomes, as well as race disparities in this association, to clarify the long-term public health impact of pandemic-related lifestyle changes. The data collected by this supplement efficiently leverages the parent grant (focused on CV risks and brain outcomes) in a population with substantial minority representation (35% African-American) and could identify targets for a novel lifestyle intervention to be rapidly deployed and scaled in a future pandemic as a way to preserve health. Leveraging the long-standing NIH investment in the Bogalusa Heart Study is the optimal approach for investigating the effects of pandemic-related sudden CV risk factor changes on cognitive and brain health.