Unraveling epigenetic mechanisms of opioid addiction susceptibility using multigenerational animal models

使用多代动物模型揭示阿片类药物成瘾易感性的表观遗传机制

• 批准号: 10161360
• 负责人: Mathieu Wimmer
• 金额: $ 6.09万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10161360
• 关键词: Adolescence; Adult; Affect; Animal Model; Behavior; Behavioral; Biological; Biological Markers; Brain; Child; Conceptions; Consumption; Drug Addiction; Drug abuse; Environmental Risk Factor; Epigenetic Process; Family; Fathers; Gene Expression; Generations; Individual; Lead; Life; Mental disorders; Molecular; Morphine; Neurobiology; Opiate Addiction; Opioid; Pharmaceutical Preparations; Predisposition; Puberty; Public Health; Research; Shapes; Signal Pathway; Societies; Time; addiction; offspring; opioid exposure; trait

Project Summary/Abstract Drug addiction is a massive public health concern that inflicts extensive burdens on our economy and society. The harmful consequences of drug abuse extend far beyond the addicts and gravely impact their families. A growing body of evidence suggests that the children of fathers who consumed drugs around the time of conception show altered brain function and behavioral abnormalities. Using a highly translational paradigm of paternal opioid drug taking, this projects aims to identify biomarkers and mechanisms predictive of addiction susceptibility. The focus of the proposed studies will be changes in gene expression and behavior produced by paternal opioid exposure that emerge during adolescence in first generation progeny and are predictive of higher addiction-like traits in adulthood. This multifaceted project will combine behavioral and molecular biological approaches to identify functionally relevant mechanisms during puberty that confer a higher propensity to develop addiction later in life. Overall, this research will establish a strategy to delineate functional mechanisms associated with addiction susceptibility and develop a platform to study how environmental insults can shape and affect the likelihood of individuals to develop psychiatric diseases.

项目总结/文摘