1/3 Alcohol Research Consortium in HIV - Administrative Core (ARCH-AC)

这是针对艾滋病毒酒精研究联盟(ARCH)的补充资金申请 寻求在我们现有的酒精和艾滋病毒流行病学基础上增加与新冠肺炎相关的目标 干预研究。该建议利用了CFAR网络的优势 综合临床系统(CNICs)，包括系统的、持续的患者收集 定期报告结果(PRO)以及住院和门诊电子 病历(EMR)摘要。首先，使用来自所有活跃的CNICs患者的数据(N&GT； ，我们将研究在SARS-CoV-2之前和期间饮酒之间的关系 与SARS-CoV-2感染率和与新冠肺炎相关的住院情况， 住院时间、ICU入院人数和死亡率。第二，在危险物质的子集中 饮酒者(N=100/站点跨6个站点)，我们将实施新冠肺炎酒精调查以获取 关于饮酒数量/频率的纵向数据(12-18个月4次调查)， 饮酒地点和饮酒伙伴，以及饮酒动机。调查还将评估 感知到SARS-CoV-2对个人和家庭的威胁，遵守社交距离和 居家订单，新冠肺炎特有的压力源(例如，降低工资，减少/不照顾儿童， 粮食短缺、交通、因持续健康问题而获得医疗保健的机会)，以及 感觉到的压力。我们将检查酒精使用特征在酒精使用期间和之后的变化 SARS-CoV-2大流行与大流行前的酒精使用模式、抑郁和 焦虑症状严重程度、感觉到的压力、对社交距离的遵从性和呆在- 家庭订单。第三，我们将研究酒精使用模式的变化对艾滋病毒的影响 治疗结果。我们将使用酒精生物标记物来验证饮酒报告 调查参与者的子样本(N=40个/站点，涉及6个站点)。最后，调查参与者将对 他们对远程健康酒精咨询的兴趣，并提供关于可获得 用于实施的设备和互联网接入。关于新冠肺炎相关变化的调查结果 饮酒特征和患者对远程医疗模式的兴趣将使我们能够 在未来有效实施酒精干预的远程咨询模式。

This supplemental funding application for the Alcohol Research Consortium on HIV (ARCH) seeks to add COVID-19 related aims to our existing alcohol and HIV epidemiologic and intervention research. This proposal capitalizes on the strengths of the CFAR Network of Integrated Clinical Systems (CNICS), which include systematic, on-going collection of patient reported outcomes (PROs) at regular intervals as well as inpatient and outpatient electronic medical record (EMR) abstraction. First, using data from all active CNICS patients (N > 13,000), we will examine associations between alcohol use prior to and during the SARS-CoV-2 pandemic with rates of SARS-CoV-2 infection, and COVID-19-related hospitalizations, hospitalization duration, ICU admissions, and mortality. Second, in a subset of hazardous drinkers (N=100/site across 6 sites), we will implement a COVID-19 alcohol survey to capture longitudinal data (4 surveys over 12 – 18 months) on quantity/frequency of alcohol consumption, drinking locations and partners, as well as motivations for drinking. The survey also will assess perceived personal and family threat from SARS-CoV-2, compliance with social distancing and stay-at-home orders, COVID-19 specific stressors (e.g., reduced wages, reduced/no childcare, food shortage, transportation, access to health care for ongoing health problems), and levels of perceived stress. We will examine changes in alcohol use characteristics during and after the SARS-CoV-2 pandemic as a function of pre-pandemic alcohol use patterns, depressive and anxiety symptom severity, perceived stress and compliance with social distancing and stay-at- home orders. Third, we will study the impact of changes in alcohol use patterns on HIV treatment outcomes. We will validate drinking self-report using the alcohol biomarker PEth in a subsample of survey participants (N=40/site across 6 sites). Finally, survey participants will rate their interest in telehealth alcohol counseling and provide information on availability of equipment and internet access for implementation. Findings on COVID-19 related changes in drinking characteristics and patient interest in telehealth care models will position us to effectively implement remote counseling models for alcohol interventions in the future.