Mentoring and Patient Oriented Research at the Nexus of Unhealthy Alcohol Use and HIV

不健康饮酒与艾滋病毒关系的指导和以患者为导向的研究

• 批准号: 10608555
• 负责人: GEETANJALI CHANDER
• 金额: $ 17.39万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-03 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608555
• 关键词: Mentoring; Patient; Oriented; Research; Nexus

Unhealthy alcohol use among persons with HIV (PWH) has deleterious effects on retention in the HIV Care Continuum, increases HIV transmission risk behaviors, complicates the management of age-related comorbidities and increases mortality. I am a general internist and clinical HIV specialist. My research career over the past 14 years has focused at the nexus of HIV and alcohol use. My research and scholarship have contributed to the understanding of the epidemiology and clinical consequences of alcohol use among PWH, and to the adaptation and testing of interventions for unhealthy alcohol use among PWH, particularly women. I seek this K24 Mid-Career Investigator Award to 1) Expand my patient oriented research skills and experience in implementation research, in order to rigorously implement evidence based alcohol interventions for PWH in clinical and community settings, allowing me to expand my patient oriented intervention research from trials of efficacy to effectiveness and implementation; and 2) increase mentoring time, enhance my mentoring and leadership skills, and thereby expand the cadre of junior faculty and trainees pursuing research careers focused on alcohol and HIV. I will accomplish these goals through didactics, training, direct experience and mentorship from experts in implementation research, mentoring and leadership development. Throughout this award period I will work closely with mentees to develop individual development plans tailored to their values and goals which will serve as a blue print for their training activities. The new research proposed in this award will capitalize on the existing resources and infrastructure of the NIAAA funded Alcohol Research Consortium in HIV (ARCH), nested in the CFAR Network of Integrated Clinical Systems (CNICS), a multi-site clinical cohort of PWH receiving care across 8 HV clinics in the United States. ARCH is testing the effectiveness of an alcohol treatment algorithm integrated into three HIV clinics. With implementation research collaborators and trainees, and skills gained from proposed K24 career development activities, I will use mixed methods to explore and evaluate multi-level factors that influence adoption, implementation and maintenance of this approach to alcohol treatment in HIV clinical settings. This mixed methods research, which includes in-depth interviews and quantitative surveys, will provide a number of opportunities for trainees interested in implementation research focused on alcohol and HIV. I have a strong record of research funding, and am a long-standing investigator with the Johns Hopkins HIV Clinical Cohort, ARCH, and a behavioral clinical trials program for women with and at risk of HIV. These resources, combined with the strong scientific environment at Johns Hopkins, serve as an outstanding platform to train the next generation of investigators in the areas of alcohol use and HIV.

艾滋病毒（PWH）的患者之间的不健康饮酒对艾滋病毒护理中的保留有害影响 连续体，增加HIV传播风险行为，使与年龄有关的管理复杂化 合并症并增加死亡率。我是一名普通内科医生和临床艾滋病毒专家。我的研究生涯 在过去的14年中，人们集中于艾滋病毒和饮酒的联系。我的研究和奖学金 有助于理解PWH中酒精使用的流行病学和临床后果， 以及对PWH，尤其是妇女中不健康饮酒的干预措施的适应和测试。我 寻求此K24中级研究员奖至1）扩大我的以患者为导向的研究技能和经验 在实施研究中，为了严格实施基于证据的酒精干预PWH 临床和社区环境，使我能够将以患者为导向的干预研究扩大 有效性和实施的功效； 2）增加指导时间，增强我的指导和 领导技能，从而扩大从事研究职业的初级教师和学员的干部 专注于酒精和艾滋病毒。我将通过教学，培训，直接经验来实现这些目标 实施研究，指导和领导力发展专家的指导。在整个过程中 奖励期我将与受训者紧密合作，以制定根据其价值观量身定制的个人发展计划 以及将作为其培训活动的蓝图的目标。该奖项提出的新研究 将利用NIAAA资助的酒精研究联盟的现有资源和基础设施 在HIV（ARCH）中，嵌套在CFAR Integrated Clinical Systems（CNIC）中，这是一种多站点临床队列 PWH在美国的8个HV诊所接受护理。拱门正在测试酒精的有效性 整合到三个HIV诊所中的治疗算法。在实施研究合作者和受训者的情况下， 以及从拟议的K24职业发展活动中获得的技能，我将使用混合的方法来探索和 评估影响采用，实施和维护这种方法的多层次因素 艾滋病毒临床环境中的酒精治疗。这项混合方法研究包括深入访谈和 定量调查将为对实施研究感兴趣的学员提供许多机会 专注于酒精和艾滋病毒。我的研究资助有很强的记录，并且是一位长期的调查员 与约翰·霍普金斯（Johns Hopkins）艾滋病毒临床队列，拱门和针对患有和的行为临床试验计划 有艾滋病毒的风险。这些资源与约翰·霍普金斯（Johns Hopkins）的强大科学环境相结合，成为 培训下一代调查人员在酒精和艾滋病毒领域的杰出平台。