Mentoring and Patient Oriented Research at the Nexus of Unhealthy Alcohol Use and HIV

HIV感染者(PWH)中不健康的饮酒对HIV护理中的滞留有有害影响 连续体，增加艾滋病毒传播危险行为，使与年龄相关的管理复杂化 并存并增加死亡率。我是一名普通内科医生和临床艾滋病毒专家。我的研究生涯 在过去的14年里，重点关注艾滋病毒和酒精使用的关系。我的研究和学术成就 有助于了解威斯康星医院中饮酒的流行病学和临床后果， 以及对威尔斯亲王医院，特别是妇女中不健康饮酒的干预措施的适应和测试。我 寻求K24职业生涯中期研究人员奖以1)扩展我以患者为中心的研究技能和经验 在实施研究中，为了严格实施基于证据的酒精干预措施， 临床和社区环境，使我能够扩展我的以患者为中心的干预研究，从 有效性和实施的有效性；以及2)增加指导时间，加强指导和 领导技能，从而扩大初级教员和从事研究事业的实习生的干部队伍 重点关注酒精和艾滋病毒。我将通过教学、培训、直接体验和 来自实施研究、指导和领导力发展方面的专家的指导。在整个过程中 获奖期I将与学员密切合作，制定适合学员价值观的个人发展计划 和目标，这些目标将成为他们训练活动的蓝图。该奖项中提出的新研究 将利用NIAAA资助的酒精研究联盟的现有资源和基础设施 在艾滋病毒(ARCH)中，嵌套在CFAR综合临床系统网络(CNICs)中，这是一个多地点临床队列 威尔斯亲王医院在美国的8家高压诊所接受护理。阿奇正在测试一种酒精的有效性 治疗算法集成到三家艾滋病毒诊所。与实施研究合作者和受训人员合作， 和从拟议的K24职业发展活动中获得的技能，我将使用混合方法来探索和 评估影响该方法的采用、实施和维护的多层次因素 艾滋病毒临床环境中的酒精治疗。这项混合方法的研究，包括深入访谈和 定量调查，将为对实施研究感兴趣的受训者提供许多机会 重点关注酒精和艾滋病毒。我在研究资助方面有很好的记录，而且是一名长期的研究员 与约翰霍普金斯大学艾滋病毒临床队列，ARCH和一个行为临床试验计划的妇女和 有感染艾滋病毒的风险。这些资源，与约翰霍普金斯大学强大的科学环境相结合，成为 为培训酒精使用和艾滋病毒领域的下一代调查人员提供了出色的平台。

Unhealthy alcohol use among persons with HIV (PWH) has deleterious effects on retention in the HIV Care Continuum, increases HIV transmission risk behaviors, complicates the management of age-related comorbidities and increases mortality. I am a general internist and clinical HIV specialist. My research career over the past 14 years has focused at the nexus of HIV and alcohol use. My research and scholarship have contributed to the understanding of the epidemiology and clinical consequences of alcohol use among PWH, and to the adaptation and testing of interventions for unhealthy alcohol use among PWH, particularly women. I seek this K24 Mid-Career Investigator Award to 1) Expand my patient oriented research skills and experience in implementation research, in order to rigorously implement evidence based alcohol interventions for PWH in clinical and community settings, allowing me to expand my patient oriented intervention research from trials of efficacy to effectiveness and implementation; and 2) increase mentoring time, enhance my mentoring and leadership skills, and thereby expand the cadre of junior faculty and trainees pursuing research careers focused on alcohol and HIV. I will accomplish these goals through didactics, training, direct experience and mentorship from experts in implementation research, mentoring and leadership development. Throughout this award period I will work closely with mentees to develop individual development plans tailored to their values and goals which will serve as a blue print for their training activities. The new research proposed in this award will capitalize on the existing resources and infrastructure of the NIAAA funded Alcohol Research Consortium in HIV (ARCH), nested in the CFAR Network of Integrated Clinical Systems (CNICS), a multi-site clinical cohort of PWH receiving care across 8 HV clinics in the United States. ARCH is testing the effectiveness of an alcohol treatment algorithm integrated into three HIV clinics. With implementation research collaborators and trainees, and skills gained from proposed K24 career development activities, I will use mixed methods to explore and evaluate multi-level factors that influence adoption, implementation and maintenance of this approach to alcohol treatment in HIV clinical settings. This mixed methods research, which includes in-depth interviews and quantitative surveys, will provide a number of opportunities for trainees interested in implementation research focused on alcohol and HIV. I have a strong record of research funding, and am a long-standing investigator with the Johns Hopkins HIV Clinical Cohort, ARCH, and a behavioral clinical trials program for women with and at risk of HIV. These resources, combined with the strong scientific environment at Johns Hopkins, serve as an outstanding platform to train the next generation of investigators in the areas of alcohol use and HIV.