HIV and Substance Use Cohort Coordinating Center for Emerging and High Impact Scientific Cross Cohort Studies: HIV SUCCESS

艾滋病毒和药物使用队列协调中心的目的是应对新出现的和高度影响 科学交叉队列研究：艾滋病毒的成功是支持国家药物滥用研究所资助的队列 他们实施研究战略，以更好地了解和解决物质使用及其后果 在艾滋病毒携带者(PWH)中。威尔斯亲王的药物使用率很高，药物使用模式， 包括增加甲基苯丙胺/阿片类药物的同时使用，作为阿片类药物流行的第四波的一部分， 继续发展。在提高对《公约》的理解和执行方面仍然存在重大挑战 针对威尔斯亲王医院药物使用及其影响的干预措施。应对这些挑战是 队列的首要目的，需要一个在数据集成方面经验丰富的协调中心(CC 和协调，健康信息学，多地点协调，临床护理和干预经验，以及 艾滋病毒和物质使用研究为队列提供支持，并全面整合跨队列数据。这个 由此产生的全面集成的数据资源将使研究人员有可能解决重要的 科学和公共卫生问题，否则在个人队列中是不可能的。我们会工作的 通过队列，允许对各种不同的结果和结果进行复杂、仔细和完整的分析 使用统一数据的人口。我们将根据需要引入其他队列和研究的数据，以确保 有足够的临床、生物标记物和/或遗传数据来解决关键问题。仔细的数据 适当时的统一将提高确定研究领域或分组的统计能力 重点关注并了解哪些干预措施在整个更广泛的背景下被证明是成功的 威尔斯亲王医院的人口(相对于单一队列的目标人口)。这个团队带来了丰富的经验 与艾滋病毒队列数据；数据联系和协调；方法发展；统计支持，包括 从纵向观测数据进行因果推断；卫生信息学平台和工具基础设施以及 开发包括数据存储库和工具在内的高效、准确的电子收集患者 报告结果和结果裁决；为大型合作提供总体协调 队列和研究；在艾滋病毒和药物使用的临床流行病学方面有很强的背景；以及在 将这些信息应用于临床护理和干预。我们也有一个全面的指导方法 开发新一代艾滋病毒和物质使用研究人员。我们将支持队列以增强数据 在适当的地方收集数据，在可行的情况下合并和协调数据，并共同努力解决关键问题 关于艾滋病毒、物质使用和结果的问题，这些问题不是个别队列所能解决的。通过提供 项目管理、指导和支持，以及开发强大的数据存储库，以及 完成数据整合联动，实现多学科融合网络 需要具有足够大小的多站点数据，以解决威尔斯亲王医院中的物质使用及其影响。

The purpose of the HIV and Substance Use Cohort Coordinating Center for Emerging and High Impact Scientific Cross Cohort Studies: HIV SUCCESS is to support National Institute on Drug Abuse funded cohorts as they implement research strategies to better understand and address substance use and its consequences among people with HIV (PWH). Substance use prevalence among PWH is high, and substance use patterns, including increasing concurrent methamphetamine/opioid use as part of the 4th wave of the opioid epidemic, continue to evolve. Substantial challenges remain to improve understanding and implementation of interventions to address substance use and its impacts among PWH. Addressing these challenges is the overarching purpose of the cohorts and requires a coordinating center (CC) experienced in data integration and harmonization, health informatics, multi-site coordination, clinical care and intervention experience, and HIV and substance use research to support the cohorts and comprehensively integrate cross-cohort data. The resulting resource of comprehensively integrated data will give researchers the potential to address important scientific and public health questions that would otherwise not be possible in individual cohorts. We will work with cohorts to allow complex, careful and complete analyses of outcomes and results across diverse populations using harmonized data. We will bring in data from other cohorts and studies as needed to ensure that adequate clinical, biomarker, and/or genetic data are available to address key questions. Careful data harmonization where appropriate will improve the statistical power to identify areas or sub-groups for research focus and to understand what interventions are proving successful in the broader context of the whole population of PWH (as opposed to the target population of a single cohort). This team brings vast experience with HIV cohort data; data linkage and harmonization; methods development; statistical support including causal inference from longitudinal observational data; health informatics platform and tool infrastructure and development including data repositories and tools for efficient and accurate electronically collected patient reported outcomes and outcomes adjudication; providing overall coordination for large collaborations of cohorts and studies; a strong background in clinical epidemiology of HIV and substance use; and expertise in applying this information to clinical care and interventions. We also have a comprehensive mentoring approach to develop a new generation of HIV and substance use researchers. We will support cohorts to enhance data collection where appropriate, merge and harmonize data when feasible, and work together to address key questions on HIV, substance use, and outcomes that cannot be addressed by individual cohorts. By providing project management, mentorship, and support, as well as developing a robust data repository, and accomplishing the integration and linkage of data, we will achieve a multi-disciplinary integrated network with multi-site data with sufficient sizes needed to address substance use and its impacts among PWH.