Enhancing HSPC CAR-mediated immunity in vivo

增强 HSPC CAR 介导的体内免疫

基本信息

  • 批准号:
    10160820
  • 负责人:
  • 金额:
    $ 45.67万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-05-07 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

Project 1: Summary/Abstract The proposed research targets an HIV-1 cure strategy that attempts to increase and optimize anti-HIV cellular immune responses, which play a critical role in the control of HIV replication in the body. Due to the durability and persistence of reservoirs of HIV infected cells, combined antiretroviral treatment (ART) is insufficient in eradicating HIV-1 from the body and the patients have to remain on treatment for the rest of their lives. Achieving HIV-1 cure or remission without ART treatment will require the enhancement and persistence of effective antiviral immune responses. Most current efforts primarily focus on enhancing immunity via genetic modification of peripheral T cells while we aim at creating lifelong anti-HIV responses by modifying autologous Hematopoietic Stem/Progenitor Cells (HSPCs) with an optimized anti-HIV Chimeric Antigen Receptor (CAR) molecule. In addition, the gene therapy vector expressing this CAR molecule also contains anti-HIV genes, which protect the newly developed, vector-containing T cells from infection. We will also explore immune and gene combination therapies to improve the safety, performance, and efficacy of the CAR HSPC-based therapy. We will use a mouse model with a surrogate system that recapitulates the human immune system and HIV pathogenesis, to select for the best CAR vector and best combination therapy design to maximize the in vivo functionality of CAR cells. We will evaluate our lead CAR candidates and combination therapy in SHIV+ infected, anti-retroviral drug-treated non-human primates (NHPs) to best mimic the human clinical setting. Our proposed study will provide crucial insights and pave the way for investigational new drug (IND) development of numerous HSPC-based CAR immunotherapies.
项目1:摘要/摘要

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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SCOTT G KITCHEN其他文献

SCOTT G KITCHEN的其他文献

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{{ truncateString('SCOTT G KITCHEN', 18)}}的其他基金

Core D -Humanized Mouse and Gene Therapy Core
Core D - 人源化小鼠和基因治疗核心
  • 批准号:
    10458373
  • 财政年份:
    2022
  • 资助金额:
    $ 45.67万
  • 项目类别:
Core D -Humanized Mouse and Gene Therapy Core
Core D - 人源化小鼠和基因治疗核心
  • 批准号:
    10609766
  • 财政年份:
    2022
  • 资助金额:
    $ 45.67万
  • 项目类别:
Therapeutic Anti-HIV Chimeric Antigen Receptors Via Stem Cell Delivery
通过干细胞递送治疗性抗 HIV 嵌合抗原受体
  • 批准号:
    10542442
  • 财政年份:
    2020
  • 资助金额:
    $ 45.67万
  • 项目类别:
Enhancing HSPC CAR-mediated immunity in vivo
增强 HSPC CAR 介导的体内免疫
  • 批准号:
    10614642
  • 财政年份:
    2020
  • 资助金额:
    $ 45.67万
  • 项目类别:
Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infection
明确THC和CBD对HIV感染期间IFN-I介导的炎症和免疫功能障碍的影响和机制
  • 批准号:
    10657439
  • 财政年份:
    2020
  • 资助金额:
    $ 45.67万
  • 项目类别:
Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infection
明确THC和CBD对HIV感染期间IFN-I介导的炎症和免疫功能障碍的影响和机制
  • 批准号:
    10267753
  • 财政年份:
    2020
  • 资助金额:
    $ 45.67万
  • 项目类别:
Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infection
明确THC和CBD对HIV感染期间IFN-I介导的炎症和免疫功能障碍的影响和机制
  • 批准号:
    10447699
  • 财政年份:
    2020
  • 资助金额:
    $ 45.67万
  • 项目类别:
Therapeutic Anti-HIV Chimeric Antigen Receptors Via Stem Cell Delivery
通过干细胞递送治疗性抗 HIV 嵌合抗原受体
  • 批准号:
    9922602
  • 财政年份:
    2020
  • 资助金额:
    $ 45.67万
  • 项目类别:
Therapeutic Anti-HIV Chimeric Antigen Receptors Via Stem Cell Delivery
通过干细胞递送治疗性抗 HIV 嵌合抗原受体
  • 批准号:
    10321545
  • 财政年份:
    2020
  • 资助金额:
    $ 45.67万
  • 项目类别:
Enhancing HSPC CAR-mediated immunity in vivo
增强 HSPC CAR 介导的体内免疫
  • 批准号:
    10468651
  • 财政年份:
    2020
  • 资助金额:
    $ 45.67万
  • 项目类别:

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