Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infection
明确THC和CBD对HIV感染期间IFN-I介导的炎症和免疫功能障碍的影响和机制
基本信息
- 批准号:10267753
- 负责人:
- 金额:$ 37.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAgonistAnalgesicsAnimalsAnti-Inflammatory AgentsAntigen-Presenting CellsAntiinflammatory EffectAntiviral AgentsAntiviral ResponseAutomobile DrivingBindingBiologicalCNR1 geneCNR2 geneCannabidiolCannabinoidsCannabisCannabis sativa plantCardiovascular DiseasesCellsChronicClinical ManagementClinical TrialsClustered Regularly Interspaced Short Palindromic RepeatsComplexConflict (Psychology)Dendritic CellsDiseaseDisease ProgressionDrug usageFrequenciesFunctional disorderGene ExpressionGenesHIVHIV InfectionsHIV-1HIV-associated neurocognitive disorderHumanImmuneImmune System DiseasesImmune systemImmunocompetenceIn VitroIndividualInfectionInflammationInflammatoryInterferon Type IInterferon-alphaInterferonsKnock-outMacaca mulattaMalignant NeoplasmsMediatingMicrogliaNeuraxisNeurodegenerative DisordersPathogenesisPatientsPlasmaPlayPredispositionPropertyReportingRoleSIVSignal PathwaySignal TransductionSpecimenT cell responseT-LymphocyteTetrahydrocannabinolUnited StatesViralViral Load resultVirus Replicationantiretroviral therapycannabinoid receptorcell typechronic inflammatory diseasecomorbiditycytokinedosageendogenous cannabinoid systemexhaustionhigh dimensionalityhumanized mouseimmune activationimmune functionimmunoregulationimprovedin vivoknock-downlatent HIV reservoirmacrophagemarijuana usemonocytemouse modelpreventreceptorresponsesmall hairpin RNA
项目摘要
Project Summary
One of the hallmarks of HIV infection is chronic immune activation/inflammation, which is strongly associated
with and predictive of HIV disease progression, even in patients that were successfully treated with anti-retroviral
therapy (ART). We and other have shown that chronic elevation of type I IFN signaling in HIV+ individuals is a
major driver in immune activation. Alleviating chronic activation may reduce disease progression and prevent or
slow down progression of HIV-associated diseases, including HIV-associated neurocognitive disorders (HAND),
which is fueled by inflammation in the central nervous system (CNS). In recent years, studies have suggested
that major components of cannabis, namely THC and CBD, may have anti-inflammatory properties. However,
the individual and combined effects and mechanisms of THC and CBD on immune activation during HIV infection
remain elusive. In this project, we aim to study the individual and combined effects of THC and CBD on immune
cell activation and CNS inflammation during HIV infection. We hypothesize that THC and CBD regulate IFN-I
mediated inflammation differently by binding to and signaling through diverse cannabinoid receptors. We will
carefully evaluate if treatment of THC and CBD have the potential to reduce chronic inflammation and improve
immune function against HIV infection.
项目摘要
HIV感染的标志之一是慢性免疫激活/炎症,这与HIV感染密切相关。
即使在成功接受抗逆转录病毒治疗的患者中,
治疗(ART)。我们和其他人已经表明,在HIV+个体中I型IFN信号的慢性升高是一种免疫抑制剂。
免疫激活的主要驱动力缓解慢性激活可以减少疾病进展并预防或
减缓艾滋病毒相关疾病的进展,包括艾滋病毒相关神经认知障碍(HAND),
其由中枢神经系统(CNS)中的炎症提供燃料。近年来,研究表明,
大麻的主要成分,即THC和CBD,可能具有抗炎特性。但是,在这方面,
THC和CBD对HIV感染期间免疫激活的单独和联合作用及机制
仍然难以捉摸在本项目中,我们的目标是研究THC和CBD对免疫的单独和联合影响
细胞活化和CNS炎症。我们假设THC和CBD调节IFN-I
通过与不同的大麻素受体结合并通过不同的大麻素受体进行信号传导,以不同的方式介导炎症。我们将
仔细评估THC和CBD的治疗是否有可能减少慢性炎症,
对HIV感染的免疫功能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('SCOTT G KITCHEN', 18)}}的其他基金
Core D -Humanized Mouse and Gene Therapy Core
Core D - 人源化小鼠和基因治疗核心
- 批准号:
10458373 - 财政年份:2022
- 资助金额:
$ 37.05万 - 项目类别:
Core D -Humanized Mouse and Gene Therapy Core
Core D - 人源化小鼠和基因治疗核心
- 批准号:
10609766 - 财政年份:2022
- 资助金额:
$ 37.05万 - 项目类别:
Enhancing HSPC CAR-mediated immunity in vivo
增强 HSPC CAR 介导的体内免疫
- 批准号:
10160820 - 财政年份:2020
- 资助金额:
$ 37.05万 - 项目类别:
Therapeutic Anti-HIV Chimeric Antigen Receptors Via Stem Cell Delivery
通过干细胞递送治疗性抗 HIV 嵌合抗原受体
- 批准号:
10542442 - 财政年份:2020
- 资助金额:
$ 37.05万 - 项目类别:
Enhancing HSPC CAR-mediated immunity in vivo
增强 HSPC CAR 介导的体内免疫
- 批准号:
10614642 - 财政年份:2020
- 资助金额:
$ 37.05万 - 项目类别:
Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infection
明确THC和CBD对HIV感染期间IFN-I介导的炎症和免疫功能障碍的影响和机制
- 批准号:
10657439 - 财政年份:2020
- 资助金额:
$ 37.05万 - 项目类别:
Define the effects and mechanism of THC and CBD on IFN-I mediated inflammation and immune dysfunction during HIV infection
明确THC和CBD对HIV感染期间IFN-I介导的炎症和免疫功能障碍的影响和机制
- 批准号:
10447699 - 财政年份:2020
- 资助金额:
$ 37.05万 - 项目类别:
Therapeutic Anti-HIV Chimeric Antigen Receptors Via Stem Cell Delivery
通过干细胞递送治疗性抗 HIV 嵌合抗原受体
- 批准号:
10321545 - 财政年份:2020
- 资助金额:
$ 37.05万 - 项目类别:
Enhancing HSPC CAR-mediated immunity in vivo
增强 HSPC CAR 介导的体内免疫
- 批准号:
10468651 - 财政年份:2020
- 资助金额:
$ 37.05万 - 项目类别:
Therapeutic Anti-HIV Chimeric Antigen Receptors Via Stem Cell Delivery
通过干细胞递送治疗性抗 HIV 嵌合抗原受体
- 批准号:
9922602 - 财政年份:2020
- 资助金额:
$ 37.05万 - 项目类别:
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