Multidisciplinary Research Fellowship in Alzheimer's disease and Related Dementias

摘要 这是第三次更新申请，要求为UCSF行为神经学培训计划提供T32资金 （BNTP），由霍华德罗森和布鲁斯米勒博士共同执导。BNTP于1999年在UCSF成立， UCSF记忆和衰老中心（MAC）培训行为神经学的临床研究人员， 神经退行性疾病该T32计划于2005年资助，允许新兴研究人员获得 综合了解神经退行性疾病的临床、流行病学、遗传和分子特征， 疾病，是世界上为数不多的提供非阿尔茨海默氏症强化训练的项目之一。 痴呆和非遗忘型AD。该计划的目标是培养博士后临床研究人员 从事神经退行性疾病研究该计划是开放给医学博士神经学家，老年病学家和 完成住院实习的精神科医生。我们计划的一个核心要素是对 痴呆亚型和预测引起神经变性的特异性蛋白质。我们的培训旨在 教授研究员评估和量化各种蛋白质和其他生物因素的影响的技能 导致痴呆症的原因。培训为期两年。 第一年包括通过我们中心的四个临床研究项目进行的研究轮换，包括我们的 额颞叶痴呆症的计划项目拨款，我们的阿尔茨海默病研究计划，我们的快速 进行性痴呆症项目和我们的临床试验项目。在这一年中，研究员开始开发 他们的研究项目与计划导师之一，并发展科学写作，演示和 使用我们临床和影像数据库的存档数据进行数据分析。在第二年，研究员们 给予更多非结构化的时间来继续他们的研究项目，并计划提交赠款，以支持他们的 未来的临床研究。多年来，我们的计划加强了与UCSF的关系 精神病学和老年医学，这影响了我们的研究，招聘和培训方法。二十- 9名研究员直接得到了T32项目的支持，但通过T32项目开发的基础设施 有助于许多额外的博士后研究员的教育。在即将到来的周期中， 将包括更多的教学课程，涉及健康的社会决定因素、卫生经济学和政策， 沿着领导力培训。

ABSTRACT This is the third renewal application requesting T32 funding for the UCSF Behavioral Neurology Training Program (BNTP), co-directed by Drs. Howard Rosen and Bruce Miller. The BNTP was established at UCSF in 1999 within the UCSF Memory and Aging Center (MAC) to train clinical researchers in behavioral neurology and neurodegenerative disease. Funded in 2005, this T32 program allows emerging researchers to gain an integrated understanding of the clinical, epidemiological, genetic, and molecular features of neurodegenerative diseases, and is one of the few programs in the world that provides intensive training on the non-Alzheimer’s dementias and non-amnestic forms of AD. The goal of the program is to train postdoctoral clinical researchers for a career in neurodegenerative research. The program is open to MD neurologists, geriatricians and psychiatrists who have completed a residency. A core element of our program is accurate classification of dementia subtypes and prediction of the specific proteins causing neurodegeneration. Our training is designed to impart fellows with the skills to evaluate and quantify the effects of various proteins and other biological factors that cause dementia using clinical assessment and laboratory methods. Training takes place over two years. The first year consists of research rotations through four clinical research programs at our center including our program project grant on frontotemporal dementia, our Alzheimer’s disease research program, our rapidly progressive dementia program and our clinical trials program. During this year, fellows begin development of their research project with one of the program mentors and develop skills in scientific writing, presentation, and in data analysis using archival data from our clinical and imaging databases. In the second year, fellows are given more unstructured time to continue their research project and plan for grant submissions to support their future career in clinical research. Over the years, our program has strengthened relationships with UCSF Psychiatry and Geriatrics, and this has influenced our research, recruitment, and approach to training. Twenty- nine fellows have been supported directly by this T32, but the infrastructure developed through the T32 program contributes to the education of many additional postdoctoral fellows. In the upcoming cycle the training program will include additional didactic sessions covering social determinants of health, health economics and policy, along with leadership training.