New Approaches to Dementia Heterogeneity
痴呆症异质性的新方法
基本信息
- 批准号:9922212
- 负责人:
- 金额:$ 315.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AgingAlzheimer&aposs DiseaseAmericanAwardBasic ScienceBiologicalBiological MarkersBiologyBiometryCaregiver supportCaringChinese PeopleClinicalClinical DataClinical PathsClinical TrialsCognition DisordersCollaborationsCollectionCommunitiesCreutzfeldt-Jakob SyndromeDataDementiaDiagnosisDiagnosticDiseaseEducationEvaluationFilmFoundationsFrontotemporal DementiaFundingGenderGenerationsGeneticGenomicsGrantHeterogeneityImageIndustry CollaborationInstitutesInternationalK-Series Research Career ProgramsKnowledgeLatinoLeadLeadershipMedicalMedical GeneticsMemoryMinorityModelingMolecularNeurodegenerative DisordersNeurologicNeurologistNeurosciencesNursesOnline SystemsPathologicPathologyPerformancePhysiologicalPoliciesPopulation HeterogeneityPresenile Alzheimer DementiaProcessProgressive Supranuclear PalsyProteomicsPublic HealthResearchResearch PersonnelResourcesSamplingScienceScientistSiteSpecialistSpecialized CenterTabletsTalentsTauopathiesTrainingUnited States National Institutes of HealthWorkbasebrain healthcareercatalystclinical centerclinical diagnosticsclinical phenotypecohortcommunity centercorticobasal syndromedata managementdata sharingdrug developmenteducation researchethnic diversityhealth care deliveryhealth economicshealth equityhealthy agingimaging biomarkerimprovedinnovationlecturesnormal agingnovelnovel strategiesoutreachprogramsranpirnaserecruitstatisticssymposiumtau Proteinstherapy developmenttranscriptomicstranslational scientist
项目摘要
ABSTRACT
The UCSF Alzheimer’s Disease Research Center (ADRC) is a major catalyst for a broad spectrum of
dementia-related research conducted at UCSF and has served as a cornerstone for national and international
multi-site diagnostic and treatment studies. In three previous cycles of funding under the P50 mechanism, we
have organized a critical mass of dementia research and share our resources widely. We excel in clinical
phenotyping, imaging, biospecimen collection, and pathologic evaluation of large and unique cohorts of early-
onset AD (EOAD), frontotemporal dementia (FTD), progressive supranuclear palsy (PSP), corticobasal
syndrome (CBS), Creutzfeldt-Jakob disease (CJD), and healthy controls. The ADRC supports and effectively
leverages additional NIH and foundation funding, philanthropy, and industry collaborations to accomplish its
aims. At the UCSF Memory and Aging Center alone, ADRC clinical cohorts, data, and biosamples are currently
utilized by 26 R grants, 6 K awards, 4 U grants, and 38 non-NIH grants. Projects and pilot awards have helped
launch young investigator careers and major research programs. ADRC data and biosamples are utilized
extensively by other ADRCs and an extensive network of collaborators.
In this new P30 application, we accelerate efforts to define subtypes of healthy aging, MCI, AD, FTD, PSP,
CBS, and CJD that predict specific molecular and physiological causes for dementia, improve early recognition
and tracking of transitions from normal aging to dementia, and stimulate drug development and clinical trials.
The ADRC will consist of seven cores: Administrative, Clinical, Data Management and Statistics, Pathology,
Outreach Recruitment and Engagement, Imaging, and Biomarker and a Research Education Component. These
cores will work collectively to pursue the following overarching specific aims: Aim 1: Explore the heterogeneous
features of healthy aging, MCI, AD, FTD-spectrum disorders, and CJD to better understand their clinical, genetic,
and molecular underpinnings. Aim 2: Leverage the valuable cohorts in the ADRC and the talented neuroscience
communities at UCSF and beyond to “enhance the performance of innovative research” around diagnosis and
treatment of dementia. Aim 3: Increase understanding of the unique cultural and biological features of aging
Chinese and Latino Americans, while educating these communities with outreach lectures and web-based
presentations. Aim 4: Develop innovative approaches to data management and biostatistics to support easy
access and analysis of ADRC-related data while offering statistical support to our investigators. Aim 5: Train
new leaders in dementia research with innovative education approaches and educate medical and lay
communities about the heterogeneity of dementia with conferences, web-based presentations, and films.
Aim 6: Create a new Biomarker Core to enhance the genomic, proteomic, and transcriptomic data captured from
our extensive biospecimen collection. Aim 7: Transition to a more gender and ethnically diverse ADRC
leadership by 2024.
摘要
项目成果
期刊论文数量(0)
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会议论文数量(0)
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BRUCE L MILLER其他文献
BRUCE L MILLER的其他文献
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{{ truncateString('BRUCE L MILLER', 18)}}的其他基金
Research Fellowship for Equity in Alzheimer's Disease and Brain Health
阿尔茨海默病和大脑健康公平研究奖学金
- 批准号:
10682452 - 财政年份:2022
- 资助金额:
$ 315.84万 - 项目类别:
FRONTOTEMPORAL DEMENTIA GENES, IMAGES, & EMOTIONS
额颞叶痴呆基因、图像、
- 批准号:
8363422 - 财政年份:2011
- 资助金额:
$ 315.84万 - 项目类别:
FRONTOTEMPORAL DEMENTIA GENES, IMAGES, & EMOTIONS
额颞叶痴呆基因、图像、
- 批准号:
8171026 - 财政年份:2010
- 资助金额:
$ 315.84万 - 项目类别:
MNT OF HYPHAL POLARITY BY DOPA PROTEIN AND ITS ROLE IN ASPERGILLUS PATHOGENESIS
多巴蛋白对菌丝极性的影响及其在曲霉菌发病中的作用
- 批准号:
7959730 - 财政年份:2009
- 资助金额:
$ 315.84万 - 项目类别:
FRONTOTEMPORAL DEMENTIA GENES, IMAGES, & EMOTIONS
额颞叶痴呆基因、图像、
- 批准号:
7955632 - 财政年份:2009
- 资助金额:
$ 315.84万 - 项目类别: