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Ultra-high field GluCEST MRI and MRS in youth at risk for psychosis

超高场 GluCEST MRI 和 MRS 在有精神病风险的青少年中的应用

基本信息

批准号：
10162387
负责人：
DAVID R ROALF
金额：
$ 75.9万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-10 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10162387
关键词：
Adolescence Adolescent Adolescent Behavior Age Anterior Antipsychotic Agents Area Axon Biological Brain Chemicals Clinical Cognitive deficits Complement Corpus Callosum Data Development Diagnosis Diagnostic Diffusion Magnetic Resonance Imaging Disease Progression Dopamine Etiology Exhibits Functional disorder Funding Glutamate Receptor Glutamates Glutamine Health Human Image Impairment Individual Learning Link Machine Learning Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measurable Measures Medial Memory Motor N-Methylaspartate Neurons Neurotransmitters Parietal Lobe Patients Pattern Pharmaceutical Preparations Play Prefrontal Cortex Protons Psychiatry Psychoses Puberty Public Health Research Risk Role Sampling Schizophrenia Science Sensory Societies Source Structural defect Structure Symptoms Synapses System Techniques Time Work Youth cohort cost effective therapy emerging adult frontal lobe gamma-Aminobutyric Acid high risk in vivo in vivo monitoring innovation longitudinal design multilevel analysis neurochemistry neurodevelopment neuroinflammation neuropsychiatric disorder neurotransmission novel novel imaging technique precision medicine recruit trend white matter

项目摘要

ABSTRACT: Psychosis commonly develops in adolescence or early adulthood. Malfunctioning neurotransmitter systems, such as glutamate, are implicated in the disease progression of psychosis. Changes in brain glutamate in psychosis likely have several sources, as such, many frontline antipsychotic medications indirectly target the glutamate system and alleviate clinical symptoms. Unfortunately, monitoring in vivo alterations of the glutamate system within the brain are spatially limited by traditional magnetic resonance techniques. But, recently a novel 7T MRI technique (GluCEST) has shown that brain glutamate levels are lower across the brain in youth on the psychosis spectrum and patients with schizophrenia as compared to typically developing youth. Here, we propose to extend this novel work to directly measure glutamate within the brain of patients at risk for developing psychosis. Thus, this proposal is motivated by the need to better understand associations of brain neurochemistry, structure and function in both normal development and during early psychosis. In this study, we seek to 1) compare measures of glutamatergic development across the cortex in a cohort of typically developing (TD) youth, those at-clinical high-risk for psychosis (CHR) and individuals with frank psychosis (PSY); 2) associate changes in brain glutamate with age- and diagnosis- related structural network changes in those at risk for developing psychosis; and 3) to establish comparison data of glutamate measures at 7T MRI (1HMRS vs. GluCEST). We will recruit and follow 35 TD, CHR and PSY over the 5-year funding period. Imaging data will be acquired at 7T and analyses will leverage recent advances in network science and machine learning. We believe this innovative approach can significantly advance our understanding of the etiology of glutamate hypofunction in psychosis and provide advances to precision medicine in psychiatry. Through the proposed multi-level analysis, this innovative research will provide a substantial advance in our understanding of the neurodevelopmental substrates of psychosis.

摘要：精神病通常发生在青春期或成年早期。故障