Vanderbilt O'Brien Kidney Center

范德比尔特奥布莱恩肾脏中心

• 批准号: 10163162
• 负责人: RAYMOND C. HARRIS
• 金额: $ 118.5万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-08 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10163162
• 关键词: Acute; Acute Renal Failure with Renal Papillary Necrosis; Advanced Development; Animals; Biomedical Research; Chronic Kidney Failure; Clinical; Clinical Research; Development; Diabetic Nephropathy; Educational Activities; Fibrosis; Functional disorder; Funding; Genome engineering; Goals; Grant; Histology; Hypertension; Industry; Infrastructure; Injury to Kidney; Institution; International; Investigation; Kidney; Kidney Diseases; Mission; Pathogenesis; Pharmacologic Substance; Phenotype; Pre-Clinical Model; Prevention; Research; Research Personnel; Resources; Scientist; Services; Structure; Translational Research; Translations; Vision; base; biomedical resource; cellular engineering; clinical translation; epidemiology study; insight; member; molecular pathology; novel; novel strategies; novel therapeutic intervention; novel therapeutics; programs; web site

The mission of the Vanderbilt O'Brien Kidney Center (VOKC) is to advance research opportunities for kidney related research and promote effective interactions between basic scientists and clinical researchers in order to advance effective prevention and treatment of acute and chronic kidney disease and their complications. To accomplish its mission, the Vanderbilt O'Brien Kidney Center supports Biomedical Research Cores, Pilot and Feasibility Grants and a robust Educational Enrichment Program. There are three Biomedical Research Cores that provide services to investigators utilizing preclinical models of kidney injury: a Phenotyping and Pathophysiology Core, an Histology and Molecular Pathology Core and a Cell and Genome Engineering Core and a robust Clinical and Translation Core for investigators involved in translational and epidemiologic research. These Cores support kidney research that is conducted by 92 investigators at Vanderbilt. In addition, our goal in developing the VOKC is for it to serve as a national and international resource, and, as indicated in the description of the Biomedical Research Base, investigators at institutions in both the U.S. and abroad have utilized resources of the Biomedical Core; in addition, we have provided services to a number of pharmaceutical companies. During its previous funding period, the Center supported studies that have provided new insights into the pathogenesis and treatment of diabetic nephropathy, hypertension, acute kidney injury, glomerular and tubulointerstitial fibrosis and complications of chronic kidney disease.

范德比尔特·奥布莱恩肾脏中心（VOKC）的任务是进步研究 肾脏相关研究的机会并促进有效的互动 基础科学家和临床研究人员，以提高有效的预防和 治疗急性和慢性肾脏疾病及其并发症。实现它 Mission，Vanderbilt O'Brien肾脏中心支持生物医学研究核心， 飞行员和可行性赠款以及强大的教育丰富计划。有 三个生物医学研究核心，可为研究人员提供服务 肾损伤的临床前模型：一种表型和病理生理学核心，一种 组织学和分子病理学核心以及细胞和基因组工程核心以及 涉及翻译和的研究人员的强大临床和翻译核心 流行病学研究。这些核心支持92进行的肾脏研究 范德比尔特的调查人员。此外，我们开发VOKC的目标是使其服务 作为国家和国际资源，如 生物医学研究基础，美国和国外机构的研究人员 利用生物医学核心的资源；此外，我们为 制药公司的数量。在以前的资金期间，该中心 支持的研究为发病机理和治疗提供了新的见解 糖尿病性肾病，高血压，急性肾脏损伤，肾小球和 肾小管纤维化和慢性肾脏病的并发症。

项目成果

Genetic variation in the eicosanoid pathway is associated with non-small-cell lung cancer (NSCLC) survival.

类二十烷酸途径的遗传变异与非小细胞肺癌 (NSCLC) 的生存相关。

• DOI: 10.1371/journal.pone.0180471
• 发表时间: 2017
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Sausville,LindsayN;Jones,CarissaC;Aldrich,MelindaC;Blot,WilliamJ;Pozzi,Ambra;Williams,ScottM
• 通讯作者: Williams,ScottM

Development of a Patient Preference Survey for Wearable Kidney Replacement Therapy Devices.

开发可穿戴肾脏替代治疗设备的患者偏好调查。

• DOI: 10.34067/kid.0001862022
• 发表时间: 2022
• 期刊: Kidney360
• 作者: Flythe,JenniferE;Forfang,Derek;Gedney,Nieltje;White,DavidM;Wilkie,Caroline;Cavanaugh,KerriL;Harris,RaymondC;Unruh,Mark;Squillaci,Grace;West,Melissa;Mansfield,Carol;Soloe,CindyS;Treiman,Katherine;Wood,Dallas;Hurst,FrankP

Sugar or Fat? Renal Tubular Metabolism Reviewed in Health and Disease.

• DOI: 10.3390/nu13051580
• 发表时间: 2021-05-09
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Gewin LS

The Vanderbilt O'Brien Kidney Center.

范德比尔特奥布莱恩肾脏中心。

• DOI: 10.1152/ajprenal.00452.2020
• 发表时间: 2021
• 期刊: American journal of physiology. Renal physiology
• 作者: Pozzi,Ambra;Harris,RaymondC
• 通讯作者: Harris,RaymondC

Integrin alpha6 maintains the structural integrity of the kidney collecting system.

整合素 α6 维持肾集合系统的结构完整性。

• DOI: 10.1016/j.matbio.2016.12.003
• 发表时间: 2017
• 期刊: Matrix biology : journal of the International Society for Matrix Biology
• 作者: Viquez,OlgaM;Yazlovitskaya,EugeniaM;Tu,Tianxiang;Mernaugh,Glenda;Secades,Pablo;McKee,KarenK;Georges-Labouesse,Elizabeth;DeArcangelis,Adele;Quaranta,Vito;Yurchenco,Peter;Gewin,LeslieC;Sonnenberg,Arnoud;Pozzi,Ambra;Zent,Roy
• 通讯作者: Zent,Roy