Nebraska Center for Nanomedicine- Pilot Projects

内布拉斯加州纳米医学中心 - 试点项目

• 批准号: 10163874
• 负责人: David Oupicky
• 金额: $ 34.31万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10163874
• 关键词: Applications Grants; Area; Award; Basic Science; Biology; Centers of Research Excellence; Clinical Investigator; Clinical Research; Collaborations; Core Facility; Data; Development; Diagnosis; Diagnostic; Discipline; Drug Delivery Systems; Engineering; Ensure; Environment; Evaluation; Extramural Activities; Faculty; Fostering; Funding; Future; Generations; Grant; Grant Review; Growth; Hypertension; Immunotherapy; Incubators; Individual; Infrastructure; Interdisciplinary Study; Intervention Studies; Joints; Laboratory Research; Lead; Life; Medicine; Mentors; Mentorship; Metabolic Diseases; Mission; Monitor; Nebraska; Notification; Nucleic Acids; Phase; Pilot Projects; Process; Request for Applications; Research; Research Personnel; Research Project Grants; Research Support; Resources; Scientist; System; Teacher Professional Development; United States National Institutes of Health; Universities; Vaccines; cancer therapy; career; catalyst; clinical translation; design; follow-up; human disease; imaging agent; improved; innovation; interest; materials science; medical specialties; member; multidisciplinary; nanomedicine; nanoparticle; novel; novel strategies; programs; recruit; research study; response; success; therapeutic protein

ABSTRACT In Phase III, the Pilot Projects Program is an integral and essential part of the Center's mission to continue to foster the careers of faculty members and promote interdisciplinary research in the broad area of nanomedicine, encompassing projects on delivery of drugs, therapeutic proteins and nucleic acids, design and development of imaging agents and their application for diagnostics and study of interventional capability of nanoparticles, biology and therapy of cancer, metabolic disorders and hypertension, immunotherapy and vaccines. The principal intents of the Pilot Project Program are (i) to attract additional junior and senior investigators into the field of nanomedicine research, (ii) promote utilization of the scientific cores, (iii) develop new collaborations and mentoring relationships to enhance the competitiveness and likelihood of success of grant applications for funding to external agencies, and (iv) stimulate new programmatic activities to build long-term sustainability of the Center. The implementation of this program in Phases I and II was highly effective: having awarded $655,000 to pilot projects, our program has led to development of multiple external awards totaling over $2,68 million. Over the five-year span of Phase III, $1,125,000 in NIH funds provided by the NCN will be partnered with $750,000 of institutional support. The rigorous evaluation process for the proposals is already in place and involves internal review and prioritization by the Scientific and Professional Development Council and external review by the EAC to ensure that funds are provided to highly meritorious pilot projects that are likely to lead to extramural research support and will stimulate multidisciplinary collaborative interactions. Core Directors will assure that they are responsive to the investigator needs in utilizing NCN research resources. Mechanisms are described for issue of RFAs, review of proposals, notification of awards, evaluation and monitoring of progress, and follow-up on grant submissions. RELEVANCE The interactions and discussions that occur within our Center facilitate generation of new ideas and new approaches. The research driven by innovators across disciplines such as material science, engineering, biology and medicine stand to impact nearly every medical specialty and unveil novel ways to improve the quality and extend the duration of life.

摘要 在第三阶段，试点项目计划是中心使命的一个不可分割的重要组成部分， 继续促进教师的职业生涯，并促进广泛的跨学科研究 纳米医学领域，包括药物、治疗性蛋白质和核酸输送项目 显像剂的设计和开发及其在诊断和研究中的应用 纳米粒子的介入能力，癌症的生物学和治疗，代谢紊乱， 高血压、免疫疗法和疫苗。试点项目计划的主要目的是（一） 为了吸引更多的初级和高级研究人员进入纳米医学研究领域，（ii）促进 利用科学核心，㈢发展新的合作和指导关系， 提高申请资助的竞争力和成功的可能性， （iv）鼓励开展新的方案活动，以建立中心的长期可持续性。 该方案在第一和第二阶段的实施非常有效： 到试点项目，我们的计划已经导致了多个外部奖励的发展，总额超过2.68美元 万在第三阶段的五年跨度中，NCN提供的1，125，000美元NIH资金将用于 获得了75万美元的机构支持。对提案的严格评估过程是 已经到位，并涉及科学和专业人员的内部审查和优先次序， 发展理事会和东非共同体的外部审查，以确保资金提供给高度 有价值的试点项目，有可能导致校外研究支持，并将刺激 多学科协作互动。核心董事将确保他们响应 研究者需要利用NCN研究资源。本报告介绍了关于发出请求协助安排的机制， 审查建议书、发出授标通知、评价和监测进展情况，以及 补助金提交。 相关性 在我们中心内发生的互动和讨论促进了新想法的产生， 新方法。由材料科学等学科的创新者推动的研究， 工程学、生物学和医学将影响几乎每一个医学专业， 提高质量和延长寿命的方法。