Nebraska Center for Nanomedicine- Pilot Projects

摘要 在第三阶段，试点项目方案是中心使命的一个组成部分，即 继续促进教职员工的职业生涯，并在广泛的范围内促进跨学科研究 纳米医学领域，包括药物、治疗性蛋白质和核的输送项目 酸、显像剂的设计和发展及其在诊断和研究中的应用 纳米粒子的介入能力、生物学和癌症、代谢紊乱和治疗 高血压、免疫治疗和疫苗。试点方案的主要目的是(一) 为吸引更多初级和高级研究人员进入纳米医学研究领域，(2)促进 利用科学核心，(3)发展新的合作和指导关系，以 提高对外拨款申请的竞争力和成功机会 在这方面，教科文组织应与各机构合作，(Iv)鼓励开展新的方案活动，以建立该中心的长期可持续性。 该方案在第一和第二阶段的执行非常有效：发放了655,000美元 作为试点项目，我们的计划促成了总额超过2，68美元的多项外部奖励的制定 百万美元。在第三阶段的五年期间，NCN提供的1,125,000美元的NIH资金将 与75万美元的机构支持结成伙伴关系。对提案的严格评估过程是 已经到位，并涉及科学和专业人员的内部审查和优先顺序 发展局和选管会的外部审查，以确保向高收入的 可能导致校外研究支持并将刺激 多学科协作互动。核心董事将保证他们对 研究人员需要利用NCN的研究资源。描述了用于发布RFA的机制， 审查提案、通知授标、评价和监测进展情况，并采取后续行动 资助金申请。 相关性 我们中心内发生的互动和讨论促进了新想法的产生和 新方法。由创新者推动的跨学科研究，如材料科学， 工程、生物和医学将影响几乎所有的医学专业，并揭开新的面纱 提高质量和延长寿命的方法。

ABSTRACT In Phase III, the Pilot Projects Program is an integral and essential part of the Center's mission to continue to foster the careers of faculty members and promote interdisciplinary research in the broad area of nanomedicine, encompassing projects on delivery of drugs, therapeutic proteins and nucleic acids, design and development of imaging agents and their application for diagnostics and study of interventional capability of nanoparticles, biology and therapy of cancer, metabolic disorders and hypertension, immunotherapy and vaccines. The principal intents of the Pilot Project Program are (i) to attract additional junior and senior investigators into the field of nanomedicine research, (ii) promote utilization of the scientific cores, (iii) develop new collaborations and mentoring relationships to enhance the competitiveness and likelihood of success of grant applications for funding to external agencies, and (iv) stimulate new programmatic activities to build long-term sustainability of the Center. The implementation of this program in Phases I and II was highly effective: having awarded $655,000 to pilot projects, our program has led to development of multiple external awards totaling over $2,68 million. Over the five-year span of Phase III, $1,125,000 in NIH funds provided by the NCN will be partnered with $750,000 of institutional support. The rigorous evaluation process for the proposals is already in place and involves internal review and prioritization by the Scientific and Professional Development Council and external review by the EAC to ensure that funds are provided to highly meritorious pilot projects that are likely to lead to extramural research support and will stimulate multidisciplinary collaborative interactions. Core Directors will assure that they are responsive to the investigator needs in utilizing NCN research resources. Mechanisms are described for issue of RFAs, review of proposals, notification of awards, evaluation and monitoring of progress, and follow-up on grant submissions. RELEVANCE The interactions and discussions that occur within our Center facilitate generation of new ideas and new approaches. The research driven by innovators across disciplines such as material science, engineering, biology and medicine stand to impact nearly every medical specialty and unveil novel ways to improve the quality and extend the duration of life.