Diversity Supplement for Ernesto Morfin Montes de Oca

项目总结/摘要 该多样性补充的目的是支持一年的学士后研究经验 埃内斯托·莫芬·蒙特斯·德奥卡Morfin Montes de Oca是URM学士学位保持器持有者，他正在申请 在2021年秋季进入MD计划。父母补助金（R01 AR074417）的目标是了解 遗传因素的骨质疏松症，以确定新的药物靶点，以减少这一巨大的健康负担。莫芬先生 Montes de Oca的工作将补充母基金的SubAim1A，这是为了识别调节 反向遗传筛查中骨矿物质密度（BMD）相关位点的骨量和矿物质增加。因为它 Morfin Montes de Oca先生将筛选与该集合互补的基因， 在父母补助金中测试。选择这些基因是为了支持遗传对BMD的影响这一假设， 部分由旁分泌或内分泌方式的基因决定。职业发展计划 Morfin Montes de Oca先生的职业目标是成为一名临床科学家。该计划包括定期 PI会议、研究俱乐部演讲、参加国家会议和临床指导 活动该项目的预期影响是，Morfin Montes de Oca先生将获得新的研究技能， 知识和经验，这将增加他的竞争力，医学院，并促进他的 发展成为临床科学家。

PROJECT SUMMARY/ABSTRACT The objective of this Diversity Supplement is to support a one-year postbaccalaureate research experience for Ernesto Morfin Montes de Oca. Morfin Montes de Oca is a URM bachelor’s degree holder who is applying to enter into an MD program in the fall of 2021. The goal of the parent grant (R01 AR074417) is to understand genetic risk factors for osteoporosis to identify new drug targets to reduce this massive health burden. Mr. Morfin Montes de Oca’s work will supplement SubAim1A of the parent grant, which is to identify novel genes regulating bone mass and mineral accrual at bone mineral density (BMD)-associated loci in a reverse genetic screen. As it relates to the parent grant, Mr. Morfin Montes de Oca will screen genes that are complementary to the set being tested in the parent grant. These genes were selected to support the hypothesis that genetic influence on BMD is determined in part by genes that function in a paracrine or endocrine manner. The career development plan is tailored to Mr. Morfin Montes de Oca’s career goal of becoming a clinician-scientist. The plan includes regular PI meetings, presentations at research clubs, attendance of national conferences, and clinical mentoring activities. The expected impact of this project is that Mr. Morfin Montes de Oca will gain new research skills, knowledge, and experience that will increase his competitiveness for medical school and facilitate his development as a clinician-scientist.