Cognitive Control in Children of SUD Parents: A Longitudinal Multimodal MRI Study

SUD 父母子女的认知控制：纵向多模态 MRI 研究

• 批准号: 10168168
• 负责人: Christina W. Hoven
• 金额: $ 15.91万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10168168
• 关键词: Address; Affect; Alcohol or Other Drugs use; Area; Behavior; COVID-19; COVID-19 pandemic; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Chicago; Child; Chronic; Cities; Climacteric; Communities; Criminal Justice; Data; Data Collection; Death Rate; Diagnosis; Diagnostic; Disadvantaged; Disasters; Economics; Elements; Epidemic; Ethnic Origin; Exposure to; Family; Fright; Future; Health Status; Health behavior; Hispanics; Impulsivity; Individual; Inequality; Insurance Coverage; Interview; Investigation; Life; Longitudinal Studies; Louisiana; Magnetic Resonance Imaging; Medical; Mental Health; Michigan; Minority; Neighborhoods; New York; New York City; Obesity; Outcome; Pain; Parents; Participant; Phase; Population; Population Heterogeneity; Predictive Factor; Preparation; Prevention; Price; Public Health; Race; Random Allocation; Reporting; Research Design; Risk Factors; Role; Sampling; Social support; Societies; Stress; System; Telephone; Telephone Interviews; Time; Translating; Trauma; Youth; base; cognitive control; cohort; coronavirus disease; design; epidemiology study; ethnic diversity; ethnic identity; family structure; fast food; follow-up; health care disparity; health disparity; improved; intergenerational; metropolitan; minority communities; multimodality; pandemic disease; parent grant; parental involvement; pediatric trauma; racial and ethnic; racial and ethnic disparities; racial diversity; recruit; response; social; social structure; socioeconomics; statistics; stressor; theories

In the context of the COVID-19 pandemic, both economic and racial/ethnic disparities have been dramatically on display, with life and death consequences. COVID-19 serves as a deadly wake-up call regarding the need to better understand how existing social, economic and health disparities are compounded in their consequences on disadvantaged communities in the wake of disaster, in this case, a deadly pandemic. If we are to develop improved preparations for responding to future epidemics, it is especially important to understand how COVID- 19 is affecting substance use (SU) and mental health (MH) across different racial/ethnic communities. Therefore, this Stress and COVID-19 (S&C) Study is designed to address such questions by expanding an ongoing study, which immediately entered the field and is recruiting a random selection of participants from four ongoing, longitudinal epidemiologic studies examining the impact of different types of trauma and stress in the York City metropolitan area, epicenter of COVID-19. Taken together, these studies encompass a broad range of SES and racial/ethnic diversity (49% minority; 51% white), with the participants thoroughly characterized in multiple waves of data during key stressors, traumas, as well as thorough diagnostic assessments of SU and MH. The first wave of the proposed S&C Study, which was initiated in mid-March 2020 to capture early indicators, is interviewing, via telephone, a random selection (n=1,000) of participants drawn from four ongoing studies (N=6,178) including the Parent Grant study which is focused on a (98%) minority population, and assessing the multifaceted impacts that COVID is CURRENTLY having, especially on SU and MH behaviors, expecting a sample of N=800. This Supplement is requested to support the follow-up phase, which will consist of two additional waves of data collection, at six and nine months after the conclusion of the first wave (months 1-3) and analysis of all waves of data. This Supplement will allow for a longitudinal trajectory analysis of the COVID-19 impact on SU and MH outcomes. Importantly, this S&C Study design also allows for the utilization of 2-4 waves of detailed pre-COVID- 19 data on each subject, including SU and MH behaviors and diagnoses, and a wide range of important risk factors for post-COVID outcomes. Thus, this Supplement will support the investigation of which factors predict COVID-driven trajectories of SU and MH outcomes, as well as other COVID-driven life changes. The cohorts being combined for this study were originally chosen for their unique exposures to different forms of childhood trauma: including disaster (9/11), parental involvement with the criminal justice system and parental SUD., Thus, this proposed study will help us determine how prior trauma impacts subsequent COVID-19 behaviors, especially SU and MH across different exposures and across disparate racial/ethnic and socioeconomic groups. Taken together, the design features of this proposed study represent a unique opportunity to examine how pre-existing and current disparities are contributing to COVID-19 outcome disparities in SU and MH burden.

在COVID-19大流行的背景下，经济和种族/民族差异都急剧扩大， 展示出来，会带来生与死COVID-19是一个致命的警钟， 更好地了解现有的社会、经济和健康差距如何加剧其后果 在灾难发生后，在这种情况下，一种致命的流行病。如果我们要发展 为了更好地应对未来的流行病，特别重要的是要了解COVID- 19正在影响不同种族/民族社区的物质使用（SU）和心理健康（MH）。因此，我们认为， 这项压力和COVID-19（S&C）研究旨在通过扩展正在进行的研究来解决这些问题， 它立即进入了这个领域，并从四个正在进行的项目中随机挑选参与者， 纵向流行病学研究，检查约克市不同类型的创伤和压力的影响 大都会地区，COVID-19的中心。总之，这些研究涵盖了广泛的社会经济地位， 种族/民族多样性（49%为少数民族; 51%为白色），参与者在多个波中被彻底描述 关键压力源、创伤以及SU和MH的全面诊断评估期间的数据。第一波 建议中的统计调查研究于2020年3月中旬展开，以捕捉早期指标，现正进行访问， 通过电话，从4项正在进行的研究（N= 6，178）中随机选择（n= 1，000）参与者，包括 父母补助研究，重点是（98%）少数民族人口，并评估多方面的影响 COVID目前具有，特别是在SU和MH行为上，预期样本N=800。 要求本补编是为了支持后续阶段，后续阶段将包括另外两波数据 第一波结束后六个月和九个月（第1-3个月）的收集以及对所有波的分析 数据本补充文件将允许对COVID-19对SU和MH的影响进行纵向轨迹分析 结果。重要的是，这种S&C研究设计还允许利用2-4波详细的COVID前- 每个受试者的19个数据，包括SU和MH行为和诊断，以及广泛的重要风险 COVID后结果的因素。因此，本补编将支持调查哪些因素预测 COVID驱动的SU和MH结果的轨迹，以及其他COVID驱动的生活变化。队列 最初选择这些儿童是因为他们接触过不同形式的童年 创伤：包括灾难（9/11），父母参与刑事司法系统和父母SUD。因此，在本发明中， 这项拟议中的研究将帮助我们确定先前的创伤如何影响随后的COVID-19行为， SU和MH在不同的暴露和不同的种族/民族和社会经济群体。采取 总之，这项拟议研究的设计特点代表了一个独特的机会，以研究如何预先存在的 目前的差异导致了SU和MH负担的COVID-19结果差异。

项目成果

Religiosity, Mental Health and Substance Use among Black and Hispanic Adults during the First Six Months of the COVID-19 Pandemic in New York City.

• DOI: 10.3390/ijerph20095632
• 发表时间: 2023-04-25
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Svob, Connie;Lin, Susan X;Cheslack-Postava, Keely;Bresnahan, Michaeline;Goodwin, Renee D;Skokauskas, Norbert;Musa, George J;Hankerson, Sidney H;Dreher, Diane R;Ryan, Megan;Hsu, Yi-Ju;Jonsson-Cohen, Anna-Lena;Hoven, Christina W
• 通讯作者: Hoven, Christina W

Changes in appetite during quarantine and their association with pre-COVID-19 mental and physical health.

• DOI: 10.1016/j.appet.2022.106104
• 发表时间: 2022-09-01
• 期刊: APPETITE
• 影响因子: 5.4
• 作者: Rodriguez-Moreno, Diana, V;Vazquez, Sima;Cheslack-Postava, Keely;Xu, Guangling;Cycowicz, Yael M.
• 通讯作者: Cycowicz, Yael M.

Delay discounting and neurocognitive correlates among inner city adolescents with and without family history of substance use disorder.

• DOI: 10.1016/j.dcn.2021.100942
• 发表时间: 2021-04
• 期刊: Developmental cognitive neuroscience
• 影响因子: 4.7
• 作者: Rodriguez-Moreno DV;Cycowicz YM;Figner B;Wang Z;He X;Geronazzo-Alman L;Sun X;Cheslack-Postava K;Bisaga A;Hoven CW;Amsel LV
• 通讯作者: Amsel LV

Shapes of subcortical structures in adolescents with and without familial history of substance use disorder.

• DOI: 10.1002/hbm.25804
• 发表时间: 2022-06-15
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Wang, Zhishun;Rodriguez-Moreno, Diana V.;Cycowicz, Yael M.;Amsel, Lawrence V.;Cheslack-Postava, Keely;He, Xiaofu;Ryan, Megan;Geronazzo-Alman, Lupo;Musa, George J.;Bisaga, Adam;Hoven, Christina W.
• 通讯作者: Hoven, Christina W.