Tufts Clinical and Translational Science Institute (N3C Supplement)

项目总结 塔夫茨临床和翻译科学研究所(塔夫茨CTSI)基于这样一种信念： 临床和转化性研究(CTR)的整个领域的真正参与是 对于实现生物医学科学满足公众需求的承诺至关重要。这 不仅包括从长凳到床边的翻译(T1翻译)，而且至关重要的是， 对健康产生影响，转化为有效的临床实践(T2)，提供护理和公共服务 健康(T3)和健康政策(T4)。所有这些方面的进展越来越依赖于 有效利用来自多个领域的科学数据。 新冠肺炎全球紧急情况既是迫在眉睫的挑战，也是机遇 美国国立卫生研究院强调的重要数据共享目标的进展。作为回应，NCATS和 翻译科学奖中心(CTSA)中心、几个HHS机构和其他机构 合作组织致力于开发下一代临床存储库 与新冠肺炎相关的数据，国家COVID队列合作(N3C)，作为一种手段 加快对这种疾病的全球研究，并帮助发展诊断学， 治疗学和有效的疫苗。N3C倡议的目标是提高效率和 临床数据分析的可获得性与 Tuft CTSI，旨在通过以下方式减少医疗保健和研究整合的障碍 提供创新的系统、数据存储库和分析工具，并通过实现更多 通过互操作性、标准化和资源共享进行交流和协作。在- 本着共同的目标，在本补编中，我们寻求作为一个 数据提供商和思想合作伙伴通过以下具体目标：(1)继续发挥 为N3C的分析平台提供工具和资源的重要角色；以及(2)确保Tuft CTSI的信息学计划有足够的工作人员和技术资源来继续提供 将特定于COVID的患者数据从我们的中心传输到N3C存储库。

PROJECT SUMMARY Tufts Clinical and Translational Science Institute (Tufts CTSI) is based on the conviction that authentic involvement of the entire spectrum of clinical and translational research (CTR) is critical to fulfilling the promise of biomedical science for meeting the public's needs. This includes not only from translation from bench to bedside (T1 translation), but also, crucially for having health impact, translation into effective clinical practice (T2), care delivery and public health (T3), and health policy (T4). Advances on all of these fronts is increasingly dependent on making effective use of scientific data from multiple domains. The COVID-19 global emergency presents both an immediate challenge and an opportunity to progress on important data sharing aims emphasized by NIH. In response, NCATS and the Centers for Translational Science Award (CTSA) hubs, several HHS agencies, and other partnering organizations have committed to developing a next-generation repository for clinical data related to COVID-19, the National COVID Cohort Collaborative (N3C), as a means of accelerating global research into the disease and aiding the development of diagnostics, therapeutics, and effective vaccines. The N3C initiative's goal of improving the efficiency and accessibility of analyses with clinical data is consistent with the primary informatics objectives of Tufts CTSI, which am to reduce barriers to the integration of healthcare and research by providing innovative systems, data repositories, and analytical tools, and by enabling greater exchange and collaboration through interoperability, standardization, and resource sharing. In- line with shared objectives, in this supplement we seek to contribute to the N3C initiative as a data provider and thought partner through the following specific aims: (1) continue to play an important role providing tools and resources for N3C's analytics platform; and (2) ensure Tufts CTSI's Informatics Program has sufficient staff and technical resources to continue to provide COVID-specific patient data from our hub to the N3C repository.