Tufts Clinical and Translational Science Institute

在过去的10年里，塔夫茨临床和翻译科学研究所(CTSI)将 有目的地选择合作伙伴，并组织了新的和现有的计划和活动， 目的：为临床和转化性研究(CTR)做出最大贡献。我们专注于我们最适合做的事情 基于我们特定的技能、资源、合作伙伴和机会。因此，我们已经能够 为地方、国家和地区提供独特和卓越的服务、资源、教育和指导 CTR的字段。通过此应用程序，我们很高兴能够通过扩展 我们的长期合作伙伴的贡献，并通过增加新合作伙伴的特殊资产。 随着增长，我们的指导原则没有改变：1)我们积极支持全方位的翻译 研究，我们坚持认为，无论在T1-T4连续体上的任何地方，CTR必须对潜力有一个清晰的视线 对健康的最终影响；2)在研究的所有阶段，我们实行“广泛参与的团队科学”。对于CTR 为了具有相关性和影响力，研究团队从一开始就必须有广泛的利益相关者 完成和传播；3)我们是积极的合作者。我们欣然接受我们作为“外向的CTSA”的角色。 我们相信，不同学科、利益相关者和组织之间的联系是协同的 很多层次。这为我们的中心和我们领导的多个CTSA联盟活动提供了动力；4)我们 相信只有通过让系统和过程持续评估和迭代地改进过程 我们是否会实现卓越的CTR。我们在研究过程改进方面有一个标志性计划，我们 适用于CTR，并导致我们在全国率先推出CTSA通用指标；5)我们 条件反射地寻找机会，贡献新的研究方法。开发、演示和 传播新的方法和途径是我们工作的标志，不分领域；6)严谨 针对具体角色的教育和培训是在CTR方面取得卓越成绩和推进CTR的基础。 为了服务于这些原则，我们的目标是：总体目标1)创造环境、资源和服务，以 通过利用塔夫茨CTSI的各种专业知识和资产，刺激和支持全面的CTR 合伙人。总体目标2)培养广泛参与的团队科学，积极包括利益相关者，以促进 对不同人群和整个生命周期具有相关性和影响力的翻译。总体目标3)发展， 展示和传播在方法、研究过程改进和评估方面的创新，以 推进地方和国家的CTR。总体目标4)多部位临床的先进方法和表现 塔夫茨CTSI临床研究网络、NCATS试验创新网络和其他 多机构网络。整体目标5)提供卓越的教育、培训和指导，量身定制 不同的角色和学科，以促进多样化的CTR员工队伍，并在全国共享这些资源。

Over its 10 years, Tufts Clinical and Translational Science Institute (CTSI) has brought together purposefully-selected partners and has organized new and existing programs and activities with a singular purpose to best contribute to clinical and translational research (CTR). We focus on what we are best suited to do, based on our particular skills, resources, partners, and opportunities. Thereby, we have been able to provide unique and outstanding services, resources, education, and mentorship, locally, nationally, and to the field of CTR. With this application, we are pleased to be able to substantially grow our offerings by expanding our long-standing partners’ contributions, and by adding the special assets of new partners. With growth, our guiding principles have not changed: 1) We actively support the full spectrum of translational research, and we insist that wherever on the T1-T4 continuum, CTR must have a clear line of sight to potential ultimate impact on health; 2) At all stages of research, we practice “broadly-engaged team science.” For CTR to be relevant and impactful, research teams must have a wide array of stakeholders from inception to completion and dissemination; 3) We are active collaborators. We embrace our role as “the extrovert CTSA.” We believe that connections among diverse disciplines, stakeholders, and organizations are synergistic on many levels. This has powered our hub, and our leadership of multiple CTSA Consortium activities; 4) We believe that only by having systems and processes to continually assess and to iteratively improve processes will we achieve CTR excellence. We have a signature program in research process improvement, which we apply across CTR, and which led to our leading the national roll-out of the CTSA Common Metrics; 5) We reflexively look for opportunities to contribute novel research methods. Development, demonstration, and dissemination of new methods and approaches are hallmarks of our work, regardless of domain; 6) Rigorous role-specific education and training are fundamental to excellence in, and advancing, CTR. In service of these principles, our aims are: Overall AIM 1) Create an environment, resources, and services to stimulate and support the full spectrum of CTR by leveraging the diverse expertise and assets of Tufts CTSI partners. Overall AIM 2) Cultivate broadly-engaged team science, actively including stakeholders, to promote relevant and impactful translation for diverse populations and across the lifespan. Overall AIM 3) Develop, demonstrate, and disseminate innovations in methods, research process improvement, and evaluation, to advance CTR locally and nationally. Overall AIM 4) Advance methods and performance of multi-site clinical trials, within the Tufts CTSI Clinical Research Network, the NCATS Trial Innovation Network, and in other multi-institutional networks. Overall AIM 5) Provide outstanding education, training, and mentoring, tailored to different roles and disciplines, to advance a diverse CTR workforce, and share these resources nationally.