脊髓型颈椎病临床功能的放射学标志物-猫眼课题宝

脊髓型颈椎病临床功能的放射学标志物

批准号：

10165904

负责人：

Zachary A Smith

金额：

$17.96万

依托单位：

UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

依托单位国家：

美国

项目类别：

财政年份：

2017

资助国家：

美国

项目状态：

已结题

起止时间：

2017-02-01 至 2022-01-31

来源：

https://reporter.nih.gov/project-details/10165904

关键词：

Aftercare Age Algorithms Anatomy Anterior Area Biological Markers Biomechanics Cervical Cervical spine Clinical Clinical Markers Complex Data Degenerative Disorder Demyelinations Descending Spinal Cord Tract Diagnosis Diagnostic radiologic examination Disease Fatty acid glycerol esters Functional disorder Gender Goals Head Image Individual Injury Intervention Laboratories Length Magnetic Resonance Imaging Measurement Measures Medical Care Costs Methods Motor Muscle Muscle Fatigue Neck Nervous System Physiology Nervous System Trauma Neuromechanics Neuronal Injury Neurons Normal Range Operative Surgical Procedures Outcome Pain Patients Pattern Population Posture Process Proprioception Recovery Research Proposals Resolution Roentgen Rays Role SF-36 Sensory Skeletal muscle structure of neck Spinal Spinal Cord Spinal Cord Diseases Spinal Diseases Spinal Injuries Spinal cord injury Standardization Surface Symptoms Testing Training United States National Institutes of Health Upper Extremity Vertebral column Work aged aging population base chronic pain clinical pain clinically relevant disability improved indexing negative affect nerve injury operation outcome forecast pain score patient population postoperative recovery research clinical testing skill acquisition spasticity spinal cord compression spinal pathway spinal tract statistics white matter

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Project Summary Cervical spondylotic myelopathy (CSM) is a common degenerative condition of the cervical spine that leads to pain and progressive spinal injury. Primary drivers of clinical injury in CSM include forward head posture (a biomechanical process) and spinal compression (a neuromechanical process). The current proposal seeks to define clinically-relevant radiographic biomarkers, using standard X-ray and Magnetization Transfer-MRI images, to investigate the role of head posture and spinal compression in CSM patients and age-matched controls. These biomarkers will then be directly correlated to anatomically-specific tests of clinical function, including pain, disability, strength, and coordination. The long-term goal is to develop standardized radiographic values and thresholds that can be used to identify appropriate surgical candidates and predict prognosis.

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