Radiographic markers of clinical function in Cervical Spondylotic Myelopathy

项目摘要 脊髓型颈椎病是一种常见的颈椎退行性疾病，导致 疼痛和进行性脊柱损伤。导致脊髓型颈椎病临床损伤的主要因素包括头前姿势(a 生物力学过程)和脊柱压迫(一种神经机械过程)。目前的提案旨在 使用标准X射线和磁化转移-MRI定义临床相关的放射生物标记物 影像，探讨头位和脊柱受压在CSM患者和年龄匹配中的作用 控制。然后，这些生物标记物将直接与临床功能的解剖学特定测试相关， 包括疼痛、残疾、力量和协调性。长期目标是开发标准化的 可用于识别合适的手术候选对象并预测的放射值和阈值 预后。

Project Summary Cervical spondylotic myelopathy (CSM) is a common degenerative condition of the cervical spine that leads to pain and progressive spinal injury. Primary drivers of clinical injury in CSM include forward head posture (a biomechanical process) and spinal compression (a neuromechanical process). The current proposal seeks to define clinically-relevant radiographic biomarkers, using standard X-ray and Magnetization Transfer-MRI images, to investigate the role of head posture and spinal compression in CSM patients and age-matched controls. These biomarkers will then be directly correlated to anatomically-specific tests of clinical function, including pain, disability, strength, and coordination. The long-term goal is to develop standardized radiographic values and thresholds that can be used to identify appropriate surgical candidates and predict prognosis.