Radiographic markers of clinical function in Cervical Spondylotic Myelopathy

项目摘要 脊髓型颈椎病（CSM）是一种常见的颈椎退行性疾病， 疼痛和进行性脊柱损伤。CSM中临床损伤的主要驱动因素包括头部前倾姿势（a 生物力学过程）和脊柱压缩（神经力学过程）。目前的建议旨在 使用标准X射线和磁化转移-MRI定义临床相关的放射学生物标志物 图像，以探讨CSM患者和年龄匹配的头部姿势和脊柱压缩的作用。 对照这些生物标志物将与临床功能的解剖学特异性测试直接相关， 包括疼痛、残疾、力量和协调。长远目标是发展标准化 可用于识别适当手术候选人并预测的放射学值和阈值 预后

Project Summary Cervical spondylotic myelopathy (CSM) is a common degenerative condition of the cervical spine that leads to pain and progressive spinal injury. Primary drivers of clinical injury in CSM include forward head posture (a biomechanical process) and spinal compression (a neuromechanical process). The current proposal seeks to define clinically-relevant radiographic biomarkers, using standard X-ray and Magnetization Transfer-MRI images, to investigate the role of head posture and spinal compression in CSM patients and age-matched controls. These biomarkers will then be directly correlated to anatomically-specific tests of clinical function, including pain, disability, strength, and coordination. The long-term goal is to develop standardized radiographic values and thresholds that can be used to identify appropriate surgical candidates and predict prognosis.